Mp5g18040.1

Protein

Length

1,238 amino acids

Protein family membership

Histone-lysine N-methyltransferase (IPR025778)

Homologous superfamilies

None predicted.

Domains and repeats

Domain
972 - 1,071
Tesmin/TSO1-like CXC domain (IPR033467)
CXC domain (IPR026489)
Domain
1,024 - 1,055
Pre-SET CXC domain (IPR041355)
1,087 - 1,208
SET domain (IPR001214)

1 200 400 600 800 1000 1238

Detailed signature matches

IPR025778

Histone-lysine N-methyltransferase
1. PS51576 (SAM_MT43_EZ)
  
  32 - 1,238
  
  PROSITE profiles
  PS51576 (SAM_MT43_EZ)
2. PTHR45747:SF14 (HIS...)
  
  40 - 258
  
  PANTHER
  PTHR45747:SF14 (HISTONE-LYSINE N-METHYLTRANSFERASE)
  
  302 - 1,236
  
  PANTHER
  PTHR45747:SF14 (HISTONE-LYSINE N-METHYLTRANSFERASE)
IPR033467

Tesmin/TSO1-like CXC domain
1. SM01114 (CXC_2)
  
  1,020 - 1,057
  
  SMART
  SM01114 (CXC_2)
IPR026489

CXC domain
1. PS51633 (CXC)
  
  972 - 1,071
  
  PROSITE profiles
  PS51633 (CXC)
IPR041355

Pre-SET CXC domain
1. PF18264 (preSET_CXC)
  
  1,024 - 1,055
  
  Pfam
  PF18264 (preSET_CXC)
IPR001214

SET domain
1. PF00856 (SET)
  
  1,098 - 1,201
  
  Pfam
  PF00856 (SET)
2. PS50280 (SET)
  
  1,087 - 1,202
  
  PROSITE profiles
  PS50280 (SET)
3. SM00317 (set_7)
  
  1,087 - 1,208
  
  SMART
  SM00317 (set_7)

no IPR

Unintegrated signatures

G3DSA:2.170.2... (S...)

986 - 1,204

GENE3D
G3DSA:2.170.270.10 (SET domain)
PTHR45747 (HISTONE-...)

40 - 258

PANTHER
PTHR45747 (HISTONE-LYSINE N-METHYLTRANSFERASE E(Z))

302 - 1,236

PANTHER
PTHR45747 (HISTONE-LYSINE N-METHYLTRANSFERASE E(Z))
SSF82199 (SET domain)

988 - 1,205

SUPERFAMILY
SSF82199 (SET domain)
cd10519 (SET_EZH)

1,087 - 1,203

CDD
cd10519 (SET_EZH)

Other features

Coil

44 - 64

COILS
Coil (Coil)
mobidb-lite (disord...)

714 - 777

MobiDB Lite
mobidb-lite (disorder_prediction)

809 - 833

MobiDB Lite
mobidb-lite (disorder_prediction)

1,210 - 1,238

MobiDB Lite
mobidb-lite (disorder_prediction)

607 - 687

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 42

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Polyam...)

631 - 645

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

27 - 42

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

670 - 687

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

813 - 833

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte
mobidb-lite (Polar)

607 - 622

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

646 - 669

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

743 - 764

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

Residue annotation

active site cd10519

1,096V

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,098G

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,099W

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,116Y

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,126A

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,127D

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,130G

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,134D

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,139S

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,140F

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,141L

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,142F

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,143N

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,160K

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,161F

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,162A

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,163N

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,164H

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,172A

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,199Y

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,201Y

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,202R

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)

1,203Y

active site
1,096V, 1,098G, 1,099W, 1,116Y, 1,126A, 1,127D, 1,130G, 1,134D, 1,139S, 1,140F, 1,141L, 1,142F, 1,143N, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,172A, 1,199Y, 1,201Y, 1,202R, 1,203Y
CDD
cd10519 (SET_EZH)
inhibitor binding ...

1,098G

inhibitor binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,163N
CDD
cd10519 (SET_EZH)

1,099W

inhibitor binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,163N
CDD
cd10519 (SET_EZH)

1,132I

inhibitor binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,163N
CDD
cd10519 (SET_EZH)

1,133Y

inhibitor binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,163N
CDD
cd10519 (SET_EZH)

1,140F

inhibitor binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,163N
CDD
cd10519 (SET_EZH)

1,153C

inhibitor binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,163N
CDD
cd10519 (SET_EZH)

1,160K

inhibitor binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,163N
CDD
cd10519 (SET_EZH)

1,161F

inhibitor binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,163N
CDD
cd10519 (SET_EZH)

1,163N

inhibitor binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,163N
CDD
cd10519 (SET_EZH)
SAM binding site c...

1,098G

SAM binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,201Y
CDD
cd10519 (SET_EZH)

1,099W

SAM binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,201Y
CDD
cd10519 (SET_EZH)

1,132I

SAM binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,201Y
CDD
cd10519 (SET_EZH)

1,133Y

SAM binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,201Y
CDD
cd10519 (SET_EZH)

1,140F

SAM binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,201Y
CDD
cd10519 (SET_EZH)

1,153C

SAM binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,201Y
CDD
cd10519 (SET_EZH)

1,160K

SAM binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,201Y
CDD
cd10519 (SET_EZH)

1,161F

SAM binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,201Y
CDD
cd10519 (SET_EZH)

1,162A

SAM binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,201Y
CDD
cd10519 (SET_EZH)

1,163N

SAM binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,201Y
CDD
cd10519 (SET_EZH)

1,164H

SAM binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,201Y
CDD
cd10519 (SET_EZH)

1,201Y

SAM binding site
1,098G, 1,099W, 1,132I, 1,133Y, 1,140F, 1,153C, 1,160K, 1,161F, 1,162A, 1,163N, 1,164H, 1,201Y
CDD
cd10519 (SET_EZH)
polypeptide substr...

1,116Y

polypeptide substrate binding site
1,116Y, 1,126A, 1,127D, 1,139S, 1,141L, 1,142F, 1,143N, 1,172A, 1,199Y, 1,201Y, 1,203Y
CDD
cd10519 (SET_EZH)

1,126A

polypeptide substrate binding site
1,116Y, 1,126A, 1,127D, 1,139S, 1,141L, 1,142F, 1,143N, 1,172A, 1,199Y, 1,201Y, 1,203Y
CDD
cd10519 (SET_EZH)

1,127D

polypeptide substrate binding site
1,116Y, 1,126A, 1,127D, 1,139S, 1,141L, 1,142F, 1,143N, 1,172A, 1,199Y, 1,201Y, 1,203Y
CDD
cd10519 (SET_EZH)

1,139S

polypeptide substrate binding site
1,116Y, 1,126A, 1,127D, 1,139S, 1,141L, 1,142F, 1,143N, 1,172A, 1,199Y, 1,201Y, 1,203Y
CDD
cd10519 (SET_EZH)

1,141L

polypeptide substrate binding site
1,116Y, 1,126A, 1,127D, 1,139S, 1,141L, 1,142F, 1,143N, 1,172A, 1,199Y, 1,201Y, 1,203Y
CDD
cd10519 (SET_EZH)

1,142F

polypeptide substrate binding site
1,116Y, 1,126A, 1,127D, 1,139S, 1,141L, 1,142F, 1,143N, 1,172A, 1,199Y, 1,201Y, 1,203Y
CDD
cd10519 (SET_EZH)

1,143N

polypeptide substrate binding site
1,116Y, 1,126A, 1,127D, 1,139S, 1,141L, 1,142F, 1,143N, 1,172A, 1,199Y, 1,201Y, 1,203Y
CDD
cd10519 (SET_EZH)

1,172A

polypeptide substrate binding site
1,116Y, 1,126A, 1,127D, 1,139S, 1,141L, 1,142F, 1,143N, 1,172A, 1,199Y, 1,201Y, 1,203Y
CDD
cd10519 (SET_EZH)

1,199Y

polypeptide substrate binding site
1,116Y, 1,126A, 1,127D, 1,139S, 1,141L, 1,142F, 1,143N, 1,172A, 1,199Y, 1,201Y, 1,203Y
CDD
cd10519 (SET_EZH)

1,201Y

polypeptide substrate binding site
1,116Y, 1,126A, 1,127D, 1,139S, 1,141L, 1,142F, 1,143N, 1,172A, 1,199Y, 1,201Y, 1,203Y
CDD
cd10519 (SET_EZH)

1,203Y

polypeptide substrate binding site
1,116Y, 1,126A, 1,127D, 1,139S, 1,141L, 1,142F, 1,143N, 1,172A, 1,199Y, 1,201Y, 1,203Y
CDD
cd10519 (SET_EZH)
catalytic residue ...

1,201Y

catalytic residue
1,201Y
CDD
cd10519 (SET_EZH)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005515 protein binding

Cellular Component

GO:0031519 PcG protein complex

Filter view on

Entry type

Status

Per-residue features

Mp5g18040.1

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Other features

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component