Mp1g21090.2

Protein

Length

1,409 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
524 - 603
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (IPR036097)
Homologous superfamily
591 - 798
Histidine kinase/HSP90-like ATPase superfamily (IPR036890)
1,251 - 1,402
CheY-like superfamily (IPR011006)

1 200 400 600 800 1000 1200 1409

Domains and repeats

Domain
536 - 602
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (IPR003661)
649 - 799
Histidine kinase/HSP90-like ATPase (IPR003594)
1,253 - 1,395
Signal transduction response regulator, receiver domain (IPR001789)
Domain
543 - 797
Histidine kinase domain (IPR005467)
Domain
722 - 736
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
740 - 750
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
757 - 775
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)

1 200 400 600 800 1000 1200 1409

Detailed signature matches

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
1. SSF47384 (Homodimer...)
  
  524 - 603
  
  SUPERFAMILY
  SSF47384 (Homodimeric domain of signal transducing histidine kinase)
IPR036890

Histidine kinase/HSP90-like ATPase superfamily
1. G3DSA:3.30.56...
  
  604 - 798
  
  GENE3D
  G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
2. SSF55874 (ATPase do...)
  
  721 - 793
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
  
  591 - 683
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
IPR011006

CheY-like superfamily
1. SSF52172 (CheY-like)
  
  1,251 - 1,402
  
  SUPERFAMILY
  SSF52172 (CheY-like)
IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
1. cd00082 (HisKA)
  
  537 - 598
  
  CDD
  cd00082 (HisKA)
2. SM00388 (HisKA_10)
  
  536 - 602
  
  SMART
  SM00388 (HisKA_10)
3. PF00512 (HisKA)
  
  537 - 602
  
  Pfam
  PF00512 (HisKA)
IPR005467

Histidine kinase domain
1. PS50109 (HIS_KIN)
  
  543 - 797
  
  PROSITE profiles
  PS50109 (HIS_KIN)
IPR003594

Histidine kinase/HSP90-like ATPase
1. PF02518 (HATPase_c)
  
  649 - 792
  
  Pfam
  PF02518 (HATPase_c)
2. SM00387 (HKATPase_4)
  
  649 - 799
  
  SMART
  SM00387 (HKATPase_4)
IPR004358

Signal transduction histidine kinase-related protein, C-terminal
1. PR00344 (BCTRLSENSOR)
  
  757 - 775
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  740 - 750
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  722 - 736
  
  PRINTS
  PR00344 (BCTRLSENSOR)
IPR001789

Signal transduction response regulator, receiver domain
1. PS50110 (RESPONSE_R...)
  
  1,254 - 1,395
  
  PROSITE profiles
  PS50110 (RESPONSE_REGULATORY)
2. PF00072 (Response_reg)
  
  1,255 - 1,391
  
  Pfam
  PF00072 (Response_reg)
3. SM00448 (REC_2)
  
  1,253 - 1,391
  
  SMART
  SM00448 (REC_2)

no IPR

Unintegrated signatures

G3DSA:1.10.28...

524 - 603

GENE3D
G3DSA:1.10.287.130 (G3DSA:1.10.287.130)
G3DSA:3.40.50...

1,233 - 1,402

GENE3D
G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)
PTHR43711 (TWO-COMP...)

97 - 876

PANTHER
PTHR43711 (TWO-COMPONENT HISTIDINE KINASE)

1,245 - 1,396

PANTHER
PTHR43711 (TWO-COMPONENT HISTIDINE KINASE)
PTHR43711:SF18 (SUB...)

1,245 - 1,396

PANTHER
PTHR43711:SF18 (SUBFAMILY NOT NAMED)

97 - 876

PANTHER
PTHR43711:SF18 (SUBFAMILY NOT NAMED)
cd17546 (REC_hyHK_C...)

1,255 - 1,391

CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

Other features

mobidb-lite (disord...)

1,066 - 1,091

MobiDB Lite
mobidb-lite (disorder_prediction)

1,119 - 1,148

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Polyam...)

1,128 - 1,148

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte
mobidb-lite (Polar)

1,067 - 1,091

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

Residue annotation

dimer interface cd...

540F

dimer interface
540F, 544M, 548L, 551P, 555V, 558L, 575M, 579I, 582C, 586L, 589L, 593I
CDD
cd00082 (HisKA)

544M

dimer interface
540F, 544M, 548L, 551P, 555V, 558L, 575M, 579I, 582C, 586L, 589L, 593I
CDD
cd00082 (HisKA)

548L

dimer interface
540F, 544M, 548L, 551P, 555V, 558L, 575M, 579I, 582C, 586L, 589L, 593I
CDD
cd00082 (HisKA)

551P

dimer interface
540F, 544M, 548L, 551P, 555V, 558L, 575M, 579I, 582C, 586L, 589L, 593I
CDD
cd00082 (HisKA)

555V

dimer interface
540F, 544M, 548L, 551P, 555V, 558L, 575M, 579I, 582C, 586L, 589L, 593I
CDD
cd00082 (HisKA)

558L

dimer interface
540F, 544M, 548L, 551P, 555V, 558L, 575M, 579I, 582C, 586L, 589L, 593I
CDD
cd00082 (HisKA)

575M

dimer interface
540F, 544M, 548L, 551P, 555V, 558L, 575M, 579I, 582C, 586L, 589L, 593I
CDD
cd00082 (HisKA)

579I

dimer interface
540F, 544M, 548L, 551P, 555V, 558L, 575M, 579I, 582C, 586L, 589L, 593I
CDD
cd00082 (HisKA)

582C

dimer interface
540F, 544M, 548L, 551P, 555V, 558L, 575M, 579I, 582C, 586L, 589L, 593I
CDD
cd00082 (HisKA)

586L

dimer interface
540F, 544M, 548L, 551P, 555V, 558L, 575M, 579I, 582C, 586L, 589L, 593I
CDD
cd00082 (HisKA)

589L

dimer interface
540F, 544M, 548L, 551P, 555V, 558L, 575M, 579I, 582C, 586L, 589L, 593I
CDD
cd00082 (HisKA)

593I

dimer interface
540F, 544M, 548L, 551P, 555V, 558L, 575M, 579I, 582C, 586L, 589L, 593I
CDD
cd00082 (HisKA)
phosphorylation si...

546H

phosphorylation site
546H
CDD
cd00082 (HisKA)
Hpt domain binding...

1,261T

Hpt domain binding site
1,261T, 1,263V, 1,264L, 1,266R, 1,267V, 1,270M, 1,271M, 1,274K, 1,359A, 1,381P, 1,383D, 1,384P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,263V

Hpt domain binding site
1,261T, 1,263V, 1,264L, 1,266R, 1,267V, 1,270M, 1,271M, 1,274K, 1,359A, 1,381P, 1,383D, 1,384P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,264L

Hpt domain binding site
1,261T, 1,263V, 1,264L, 1,266R, 1,267V, 1,270M, 1,271M, 1,274K, 1,359A, 1,381P, 1,383D, 1,384P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,266R

Hpt domain binding site
1,261T, 1,263V, 1,264L, 1,266R, 1,267V, 1,270M, 1,271M, 1,274K, 1,359A, 1,381P, 1,383D, 1,384P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,267V

Hpt domain binding site
1,261T, 1,263V, 1,264L, 1,266R, 1,267V, 1,270M, 1,271M, 1,274K, 1,359A, 1,381P, 1,383D, 1,384P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,270M

Hpt domain binding site
1,261T, 1,263V, 1,264L, 1,266R, 1,267V, 1,270M, 1,271M, 1,274K, 1,359A, 1,381P, 1,383D, 1,384P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,271M

Hpt domain binding site
1,261T, 1,263V, 1,264L, 1,266R, 1,267V, 1,270M, 1,271M, 1,274K, 1,359A, 1,381P, 1,383D, 1,384P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,274K

Hpt domain binding site
1,261T, 1,263V, 1,264L, 1,266R, 1,267V, 1,270M, 1,271M, 1,274K, 1,359A, 1,381P, 1,383D, 1,384P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,359A

Hpt domain binding site
1,261T, 1,263V, 1,264L, 1,266R, 1,267V, 1,270M, 1,271M, 1,274K, 1,359A, 1,381P, 1,383D, 1,384P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,381P

Hpt domain binding site
1,261T, 1,263V, 1,264L, 1,266R, 1,267V, 1,270M, 1,271M, 1,274K, 1,359A, 1,381P, 1,383D, 1,384P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,383D

Hpt domain binding site
1,261T, 1,263V, 1,264L, 1,266R, 1,267V, 1,270M, 1,271M, 1,274K, 1,359A, 1,381P, 1,383D, 1,384P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,384P

Hpt domain binding site
1,261T, 1,263V, 1,264L, 1,266R, 1,267V, 1,270M, 1,271M, 1,274K, 1,359A, 1,381P, 1,383D, 1,384P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

GO term prediction

Biological Process

GO:0000160 phosphorelay signal transduction system
GO:0007165 signal transduction
GO:0016310 phosphorylation

Molecular Function

GO:0000155 phosphorelay sensor kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component