Mp2g00170.1

Protein

Length

333 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
2 - 327
NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 250 300 333

Domains and repeats

Domain
6 - 255
NAD-dependent epimerase/dehydratase (IPR001509)

1 50 100 150 200 250 300 333

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  2 - 327
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR001509

NAD-dependent epimerase/dehydratase
1. PF01370 (Epimerase)
  
  6 - 255
  
  Pfam
  PF01370 (Epimerase)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

4 - 333

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
PTHR10366 (NAD DEPE...)

2 - 328

PANTHER
PTHR10366 (NAD DEPENDENT EPIMERASE/DEHYDRATASE)
PTHR10366:SF575 (AL...)

2 - 328

PANTHER
PTHR10366:SF575 (ALCOHOL DEHYDROGENASE-RELATED)
cd08958 (FR_SDR_e)

6 - 311

CDD
cd08958 (FR_SDR_e)

Residue annotation

NADP binding site ...

10G

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

12N

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

13G

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

14F

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

15I

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

34V

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

35R

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

61A

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

62E

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

63L

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

82T

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

83A

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

84S

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

85K

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

86V

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

125T

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

126S

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

164Y

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

168K

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

191P

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

192C

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

193T

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

194V

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)

206S

NADP binding site
10G, 12N, 13G, 14F, 15I, 34V, 35R, 61A, 62E, 63L, 82T, 83A, 84S, 85K, 86V, 125T, 126S, 164Y, 168K, 191P, 192C, 193T, 194V, 206S
CDD
cd08958 (FR_SDR_e)
substrate binding ...

86V

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

88A

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

127S

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

128M

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

129S

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

132V

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

164Y

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

191P

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

192C

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

193T

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

206S

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

209E

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

223D

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

231A

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)

301F

substrate binding site
86V, 88A, 127S, 128M, 129S, 132V, 164Y, 191P, 192C, 193T, 206S, 209E, 223D, 231A, 301F
CDD
cd08958 (FR_SDR_e)
active site cd08958

102A

active site
102A, 127S, 164Y, 168K
CDD
cd08958 (FR_SDR_e)

127S

active site
102A, 127S, 164Y, 168K
CDD
cd08958 (FR_SDR_e)

164Y

active site
102A, 127S, 164Y, 168K
CDD
cd08958 (FR_SDR_e)

168K

active site
102A, 127S, 164Y, 168K
CDD
cd08958 (FR_SDR_e)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

Mp2g00170.1

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component