Mp2g04900.1

Protein

Length

844 amino acids

Protein family membership

Heat shock protein Hsp90 family (IPR001404)

Homologous superfamilies

Homologous superfamily
81 - 290
Histidine kinase/HSP90-like ATPase superfamily (IPR036890)
347 - 628
Ribosomal protein S5 domain 2-type fold (IPR020568)
630 - 779
HSP90, C-terminal domain (IPR037196)

1 100 200 300 400 500 600 700 844

Domains and repeats

Domain
81 - 101
Heat shock protein Hsp90, N-terminal (IPR020575)
102 - 265
Histidine kinase/HSP90-like ATPase (IPR003594)
Heat shock protein Hsp90, N-terminal (IPR020575)
266 - 284
Heat shock protein Hsp90, N-terminal (IPR020575)

1 100 200 300 400 500 600 700 844

Detailed signature matches

IPR036890

Histidine kinase/HSP90-like ATPase superfamily
1. G3DSA:3.30.56...
  
  82 - 288
  
  GENE3D
  G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
2. SSF55874 (ATPase do...)
  
  81 - 290
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
IPR020568

Ribosomal protein S5 domain 2-type fold
1. SSF54211 (Ribosomal...)
  
  347 - 628
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
IPR037196

HSP90, C-terminal domain
1. SSF110942 (HSP90 C-...)
  
  651 - 774
  
  SUPERFAMILY
  SSF110942 (HSP90 C-terminal domain)
2. G3DSA:1.20.12...
  
  630 - 779
  
  GENE3D
  G3DSA:1.20.120.790 (G3DSA:1.20.120.790)
IPR001404

Heat shock protein Hsp90 family
1. PIRSF002583 (HSP90_...)
  
  54 - 817
  
  PIRSF
  PIRSF002583 (HSP90_HTPG)
2. MF_00505 (HSP90)
  
  71 - 775
  
  HAMAP
  MF_00505 (HSP90)
3. PTHR11528 (HEAT SHO...)
  
  37 - 809
  
  PANTHER
  PTHR11528 (HEAT SHOCK PROTEIN 90 FAMILY MEMBER)
4. PF00183 (HSP90)
  
  262 - 804
  
  Pfam
  PF00183 (HSP90)
IPR003594

Histidine kinase/HSP90-like ATPase
1. PF02518 (HATPase_c)
  
  104 - 259
  
  Pfam
  PF02518 (HATPase_c)
2. SM00387 (HKATPase_4)
  
  103 - 260
  
  SMART
  SM00387 (HKATPase_4)
IPR020575

Heat shock protein Hsp90, N-terminal
1. PR00775 (HEATSHOCK90)
  
  196 - 218
  
  PRINTS
  PR00775 (HEATSHOCK90)
  
  171 - 188
  
  PRINTS
  PR00775 (HEATSHOCK90)
  
  266 - 284
  
  PRINTS
  PR00775 (HEATSHOCK90)
  
  153 - 170
  
  PRINTS
  PR00775 (HEATSHOCK90)
  
  81 - 101
  
  PRINTS
  PR00775 (HEATSHOCK90)
  
  102 - 124
  
  PRINTS
  PR00775 (HEATSHOCK90)
  
  248 - 265
  
  PRINTS
  PR00775 (HEATSHOCK90)

no IPR

Unintegrated signatures

G3DSA:3.30.23...

346 - 541

GENE3D
G3DSA:3.30.230.80 (G3DSA:3.30.230.80)
G3DSA:3.30.70...

289 - 329

GENE3D
G3DSA:3.30.70.2140 (G3DSA:3.30.70.2140)
G3DSA:3.40.50...

542 - 629

GENE3D
G3DSA:3.40.50.11260 (G3DSA:3.40.50.11260)
PTHR11528:SF103 (BN...)

37 - 809

PANTHER
PTHR11528:SF103 (BNAA08G14800D PROTEIN)
cd16927 (HATPase_Hs...)

90 - 280

CDD
cd16927 (HATPase_Hsp90-like)

Other features

Coil

628 - 648

COILS
Coil (Coil)
mobidb-lite (disord...)

293 - 332

MobiDB Lite
mobidb-lite (disorder_prediction)

487 - 509

MobiDB Lite
mobidb-lite (disorder_prediction)

782 - 844

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Negati...)

786 - 832

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Negative Polyelectrolyte

297 - 324

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Negative Polyelectrolyte

Residue annotation

homodimer interfac...

91R

homodimer interface
91R, 92L, 95I, 99S, 176A, 199F
CDD
cd16927 (HATPase_Hsp90-like)

92L

homodimer interface
91R, 92L, 95I, 99S, 176A, 199F
CDD
cd16927 (HATPase_Hsp90-like)

95I

homodimer interface
91R, 92L, 95I, 99S, 176A, 199F
CDD
cd16927 (HATPase_Hsp90-like)

99S

homodimer interface
91R, 92L, 95I, 99S, 176A, 199F
CDD
cd16927 (HATPase_Hsp90-like)

176A

homodimer interface
91R, 92L, 95I, 99S, 176A, 199F
CDD
cd16927 (HATPase_Hsp90-like)

199F

homodimer interface
91R, 92L, 95I, 99S, 176A, 199F
CDD
cd16927 (HATPase_Hsp90-like)
ATP binding site c...

110E

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

114N

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

115A

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

117D

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

118A

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

121K

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

156I

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

158D

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

160G

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

162G

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

163M

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

171N

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

172L

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

174T

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

175I

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

176A

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

177K

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

178S

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

179G

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

180T

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

197G

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

198Q

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

199F

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

200G

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

201V

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

202G

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

203F

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

215V

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

217S

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

249G

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

250T

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)

252I

ATP binding site
110E, 114N, 115A, 117D, 118A, 121K, 156I, 158D, 160G, 162G, 163M, 171N, 172L, 174T, 175I, 176A, 177K, 178S, 179G, 180T, 197G, 198Q, 199F, 200G, 201V, 202G, 203F, 215V, 217S, 249G, 250T, 252I
CDD
cd16927 (HATPase_Hsp90-like)
ATP-lid cd16927

172L

ATP-lid
172L, 203F
CDD
cd16927 (HATPase_Hsp90-like)

203F

ATP-lid
172L, 203F
CDD
cd16927 (HATPase_Hsp90-like)

GO term prediction

Biological Process

GO:0006457 protein folding

Molecular Function

GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0051082 unfolded protein binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features