Mp2g07060.1

Protein

Length

411 amino acids

Protein family membership

Polyketide synthase, type III (IPR011141)

Homologous superfamilies

Homologous superfamily
9 - 251
Thiolase-like (IPR016039)
251 - 411
Thiolase-like (IPR016039)

1 50 100 150 200 250 300 350 411

Domains and repeats

Domain
28 - 244
Chalcone/stilbene synthase, N-terminal (IPR001099)
254 - 404
Chalcone/stilbene synthase, C-terminal (IPR012328)

1 50 100 150 200 250 300 350 411

Detailed signature matches

IPR016039

Thiolase-like
1. SSF53901 (Thiolase-...)
  
  29 - 249
  
  SUPERFAMILY
  SSF53901 (Thiolase-like)
  
  251 - 402
  
  SUPERFAMILY
  SSF53901 (Thiolase-like)
2. G3DSA:3.40.47.10
  
  9 - 251
  
  GENE3D
  G3DSA:3.40.47.10 (G3DSA:3.40.47.10)
  
  252 - 411
  
  GENE3D
  G3DSA:3.40.47.10 (G3DSA:3.40.47.10)
IPR011141

Polyketide synthase, type III
1. PTHR11877 (HYDROXYM...)
  
  27 - 402
  
  PANTHER
  PTHR11877 (HYDROXYMETHYLGLUTARYL-COA SYNTHASE)
2. PIRSF000451 (PKS_III)
  
  18 - 405
  
  PIRSF
  PIRSF000451 (PKS_III)
IPR001099

Chalcone/stilbene synthase, N-terminal
1. PF00195 (Chal_sti_s...)
  
  28 - 244
  
  Pfam
  PF00195 (Chal_sti_synt_N)
IPR012328

Chalcone/stilbene synthase, C-terminal
1. PF02797 (Chal_sti_s...)
  
  254 - 404
  
  Pfam
  PF02797 (Chal_sti_synt_C)
IPR018088

Chalcone/stilbene synthase, active site
1. PS00441 (CHALCONE_S...)
  
  172 - 188
  
  PROSITE patterns
  PS00441 (CHALCONE_SYNTH)

no IPR

Unintegrated signatures

PTHR11877:SF14 (CHA...)

27 - 402

PANTHER
PTHR11877:SF14 (CHALCONE SYNTHASE)
cd00831 (CHS_like)

32 - 400

CDD
cd00831 (CHS_like)

Residue annotation

malonyl-CoA bindin...

71K

malonyl-CoA binding site
71K, 74R, 75I, 231F, 281F, 322G, 323P, 324A
CDD
cd00831 (CHS_like)

74R

malonyl-CoA binding site
71K, 74R, 75I, 231F, 281F, 322G, 323P, 324A
CDD
cd00831 (CHS_like)

75I

malonyl-CoA binding site
71K, 74R, 75I, 231F, 281F, 322G, 323P, 324A
CDD
cd00831 (CHS_like)

231F

malonyl-CoA binding site
71K, 74R, 75I, 231F, 281F, 322G, 323P, 324A
CDD
cd00831 (CHS_like)

281F

malonyl-CoA binding site
71K, 74R, 75I, 231F, 281F, 322G, 323P, 324A
CDD
cd00831 (CHS_like)

322G

malonyl-CoA binding site
71K, 74R, 75I, 231F, 281F, 322G, 323P, 324A
CDD
cd00831 (CHS_like)

323P

malonyl-CoA binding site
71K, 74R, 75I, 231F, 281F, 322G, 323P, 324A
CDD
cd00831 (CHS_like)

324A

malonyl-CoA binding site
71K, 74R, 75I, 231F, 281F, 322G, 323P, 324A
CDD
cd00831 (CHS_like)
dimer interface cd...

107L

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

108N

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

111Q

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

152N

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

153M

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

158L

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

162K

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

168P

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

169N

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

170V

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

171R

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

172R

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

173V

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

174M

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

178Q

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

179G

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

188R

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

189V

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

192D

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

195E

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

196N

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

197N

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

258A

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

260E

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

261M

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

262V

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

272G

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

273H

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

274L

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

275T

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)

394T

dimer interface
107L, 108N, 111Q, 152N, 153M, 158L, 162K, 168P, 169N, 170V, 171R, 172R, 173V, 174M, 178Q, 179G, 188R, 189V, 192D, 195E, 196N, 197N, 258A, 260E, 261M, 262V, 272G, 273H, 274L, 275T, 394T
CDD
cd00831 (CHS_like)
active site cd00831

180C

active site
180C, 319H, 352N
CDD
cd00831 (CHS_like)

319H

active site
180C, 319H, 352N
CDD
cd00831 (CHS_like)

352N

active site
180C, 319H, 352N
CDD
cd00831 (CHS_like)
product binding si...

208E

product binding site
208E, 209V, 210T, 232G, 270I, 271D, 272G, 280V, 281F, 354S, 391P
CDD
cd00831 (CHS_like)

209V

product binding site
208E, 209V, 210T, 232G, 270I, 271D, 272G, 280V, 281F, 354S, 391P
CDD
cd00831 (CHS_like)

210T

product binding site
208E, 209V, 210T, 232G, 270I, 271D, 272G, 280V, 281F, 354S, 391P
CDD
cd00831 (CHS_like)

232G

product binding site
208E, 209V, 210T, 232G, 270I, 271D, 272G, 280V, 281F, 354S, 391P
CDD
cd00831 (CHS_like)

270I

product binding site
208E, 209V, 210T, 232G, 270I, 271D, 272G, 280V, 281F, 354S, 391P
CDD
cd00831 (CHS_like)

271D

product binding site
208E, 209V, 210T, 232G, 270I, 271D, 272G, 280V, 281F, 354S, 391P
CDD
cd00831 (CHS_like)

272G

product binding site
208E, 209V, 210T, 232G, 270I, 271D, 272G, 280V, 281F, 354S, 391P
CDD
cd00831 (CHS_like)

280V

product binding site
208E, 209V, 210T, 232G, 270I, 271D, 272G, 280V, 281F, 354S, 391P
CDD
cd00831 (CHS_like)

281F

product binding site
208E, 209V, 210T, 232G, 270I, 271D, 272G, 280V, 281F, 354S, 391P
CDD
cd00831 (CHS_like)

354S

product binding site
208E, 209V, 210T, 232G, 270I, 271D, 272G, 280V, 281F, 354S, 391P
CDD
cd00831 (CHS_like)

391P

product binding site
208E, 209V, 210T, 232G, 270I, 271D, 272G, 280V, 281F, 354S, 391P
CDD
cd00831 (CHS_like)

GO term prediction

Biological Process

GO:0009058 biosynthetic process

Molecular Function

GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

None predicted.

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Entry type

Status

Per-residue features