Mp2g07980.1

Protein

Length

636 amino acids

Protein family membership

Hydroxymethylglutaryl-CoA reductase, class I/II (IPR002202)
- Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type (IPR004554)

Homologous superfamilies

Homologous superfamily
144 - 548
Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily (IPR009029)
Homologous superfamily
145 - 225
Hydroxymethylglutaryl-CoA reductase, N-terminal (IPR023282)
226 - 546
Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily (IPR023074)
Homologous superfamily
276 - 392
Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily (IPR009023)

1 100 200 300 400 500 636

Domains and repeats

None predicted.

Detailed signature matches

IPR009029

Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
1. SSF56542 (Substrate...)
  
  144 - 273
  
  SUPERFAMILY
  SSF56542 (Substrate-binding domain of HMG-CoA reductase)
  
  390 - 548
  
  SUPERFAMILY
  SSF56542 (Substrate-binding domain of HMG-CoA reductase)
IPR023282

Hydroxymethylglutaryl-CoA reductase, N-terminal
1. G3DSA:1.10.32... (HMGR)
  
  145 - 225
  
  GENE3D
  G3DSA:1.10.3270.10 (HMGR)
IPR023074

Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
1. G3DSA:3.90.77...
  
  226 - 274
  
  GENE3D
  G3DSA:3.90.770.10 (G3DSA:3.90.770.10)
  
  393 - 546
  
  GENE3D
  G3DSA:3.90.770.10 (G3DSA:3.90.770.10)
IPR009023

Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
1. G3DSA:3.30.70...
  
  276 - 392
  
  GENE3D
  G3DSA:3.30.70.420 (G3DSA:3.30.70.420)
2. SSF55035 (NAD-bindi...)
  
  276 - 392
  
  SUPERFAMILY
  SSF55035 (NAD-binding domain of HMG-CoA reductase)
IPR002202

Hydroxymethylglutaryl-CoA reductase, class I/II
1. PF00368 (HMG-CoA_red)
  
  185 - 559
  
  Pfam
  PF00368 (HMG-CoA_red)
2. PS50065 (HMG_COA_RE...)
  
  155 - 559
  
  PROSITE profiles
  PS50065 (HMG_COA_REDUCTASE_4)
3. PR00071 (HMGCOARDTASE)
  
  424 - 450
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  215 - 236
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  242 - 262
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  333 - 351
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  478 - 499
  
  PRINTS
  PR00071 (HMGCOARDTASE)
  
  373 - 398
  
  PRINTS
  PR00071 (HMGCOARDTASE)
4. PTHR10572 (3-HYDROX...)
  
  17 - 569
  
  PANTHER
  PTHR10572 (3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE)
IPR004554

Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
1. TIGR00533
  
  154 - 559
  
  TIGRFAMs
  TIGR00533 (TIGR00533)
2. cd00643 (HMG-CoA_re...)
  
  156 - 559
  
  CDD
  cd00643 (HMG-CoA_reductase_classI)
IPR023076

Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
1. PS00066 (HMG_COA_RE...)
  
  335 - 349
  
  PROSITE patterns
  PS00066 (HMG_COA_REDUCTASE_1)
2. PS00318 (HMG_COA_RE...)
  
  490 - 497
  
  PROSITE patterns
  PS00318 (HMG_COA_REDUCTASE_2)
3. PS01192 (HMG_COA_RE...)
  
  544 - 557
  
  PROSITE patterns
  PS01192 (HMG_COA_REDUCTASE_3)

no IPR

Unintegrated signatures

PTHR10572:SF30 (3-H...)

17 - 569

PANTHER
PTHR10572:SF30 (3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE)

Other features

mobidb-lite (disord...)

1 - 31

MobiDB Lite
mobidb-lite (disorder_prediction)

614 - 636

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

tetramerization in...

197T

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

198L

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

200G

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

201L

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

206M

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

211I

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

214Q

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

215C

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

216C

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

217E

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

218M

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

219V

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

220I

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

221G

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

222H

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

223V

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

224Q

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

225I

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

226P

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

227V

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

228G

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

229V

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

241T

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

246T

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

247T

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

248E

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

249G

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

250C

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

251L

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

252V

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

253A

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

269S

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

271V

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

273L

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

284R

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

292A

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

324Y

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

327L

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

329G

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

330R

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

331N

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

333Y

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

370I

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

372I

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

373S

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

374G

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

375N

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

376F

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

378S

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

380K

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

381K

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

382A

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

383T

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

384A

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

385V

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

387W

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

388I

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

389E

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

396V

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

398E

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

400V

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

419E

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

420L

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

422T

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

423I

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

424K

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

425N

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

426L

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

427A

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

428G

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

429S

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

430A

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

431L

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

437G

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

438F

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

439N

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

440A

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

443A

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

444N

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

447S

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

451I

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

452A

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

456D

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

457P

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

458A

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

460N

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

461V

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

469M

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

471E

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

480H

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

482S

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

484T

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

496G

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

501S

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

502Q

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

504A

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

505C

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

507N

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

508L

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

545L

tetramerization interface
197T, 198L, 200G, 201L, 206M, 211I, 214Q, 215C, 216C, 217E, 218M, 219V, 220I, 221G, 222H, 223V, 224Q, 225I, 226P, 227V, 228G, 229V, 241T, 246T, 247T, 248E, 249G, 250C, 251L, 252V, 253A, 269S, 271V, 273L, 284R, 292A, 324Y, 327L, 329G, 330R, 331N, 333Y, 370I, 372I, 373S, 374G, 375N, 376F, 378S, 380K, 381K, 382A, 383T, 384A, 385V, 387W, 388I, 389E, 396V, 398E, 400V, 419E, 420L, 422T, 423I, 424K, 425N, 426L, 427A, 428G, 429S, 430A, 431L, 437G, 438F, 439N, 440A, 443A, 444N, 447S, 451I, 452A, 456D, 457P, 458A, 460N, 461V, 469M, 471E, 480H, 482S, 484T, 496G, 501S, 502Q, 504A, 505C, 507N, 508L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)
inhibitor binding ...

248E

inhibitor binding sites
248E, 251L, 254S, 424K, 440A, 441H, 444N, 541L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

251L

inhibitor binding sites
248E, 251L, 254S, 424K, 440A, 441H, 444N, 541L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

254S

inhibitor binding sites
248E, 251L, 254S, 424K, 440A, 441H, 444N, 541L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

424K

inhibitor binding sites
248E, 251L, 254S, 424K, 440A, 441H, 444N, 541L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

440A

inhibitor binding sites
248E, 251L, 254S, 424K, 440A, 441H, 444N, 541L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

441H

inhibitor binding sites
248E, 251L, 254S, 424K, 440A, 441H, 444N, 541L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

444N

inhibitor binding sites
248E, 251L, 254S, 424K, 440A, 441H, 444N, 541L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

541L

inhibitor binding sites
248E, 251L, 254S, 424K, 440A, 441H, 444N, 541L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)

545L

inhibitor binding sites
248E, 251L, 254S, 424K, 440A, 441H, 444N, 541L, 545L
CDD
cd00643 (HMG-CoA_reductase_classI)
catalytic residues...

248E

catalytic residues
248E, 380K, 456D, 554H
CDD
cd00643 (HMG-CoA_reductase_classI)

380K

catalytic residues
248E, 380K, 456D, 554H
CDD
cd00643 (HMG-CoA_reductase_classI)

456D

catalytic residues
248E, 380K, 456D, 554H
CDD
cd00643 (HMG-CoA_reductase_classI)

554H

catalytic residues
248E, 380K, 456D, 554H
CDD
cd00643 (HMG-CoA_reductase_classI)
substrate binding ...

248E

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

250C

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

251L

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

253A

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

254S

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

256N

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

257R

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

260K

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

411K

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

441H

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

444N

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

540S

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

541L

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

544A

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

550L

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

553S

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

554H

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)

557Y

substrate binding pocket
248E, 250C, 251L, 253A, 254S, 256N, 257R, 260K, 411K, 441H, 444N, 540S, 541L, 544A, 550L, 553S, 554H, 557Y
CDD
cd00643 (HMG-CoA_reductase_classI)
NADP(H) binding si...

279R

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

315S

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

316R

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

317F

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

340T

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

341G

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

342D

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

343A

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

344M

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

345G

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

346M

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

347N

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

348M

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

350S

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

379D

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

380K

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

456D

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

493I

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

494G

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

495G

NADP(H) binding site
279R, 315S, 316R, 317F, 340T, 341G, 342D, 343A, 344M, 345G, 346M, 347N, 348M, 350S, 379D, 380K, 456D, 493I, 494G, 495G
CDD
cd00643 (HMG-CoA_reductase_classI)

GO term prediction

Biological Process

GO:0008299 isoprenoid biosynthetic process
GO:0015936 coenzyme A metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005515 protein binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Cellular Component