Mp2g11400.2

Protein

Length

561 amino acids

Protein family membership

Isocitrate lyase (IPR006254)

Homologous superfamilies

Homologous superfamily
17 - 533
Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily (IPR015813)
Homologous superfamily
24 - 528
Pyruvate kinase-like domain superfamily (IPR040442)

1 100 200 300 400 500 561

Domains and repeats

Domain
72 - 487
ICL/PEPM domain (IPR039556)

1 100 200 300 400 500 561

Detailed signature matches

IPR015813

Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
1. SSF51621 (Phosphoen...)
  
  17 - 533
  
  SUPERFAMILY
  SSF51621 (Phosphoenolpyruvate/pyruvate domain)
IPR040442

Pyruvate kinase-like domain superfamily
1. G3DSA:3.20.20.60
  
  24 - 267
  
  GENE3D
  G3DSA:3.20.20.60 (G3DSA:3.20.20.60)
  
  376 - 528
  
  GENE3D
  G3DSA:3.20.20.60 (G3DSA:3.20.20.60)
IPR006254

Isocitrate lyase
1. PIRSF001362 (ICL)
  
  365 - 552
  
  PIRSF
  PIRSF001362 (ICL)
  
  18 - 292
  
  PIRSF
  PIRSF001362 (ICL)
2. PTHR21631 (ISOCITRA...)
  
  19 - 552
  
  PANTHER
  PTHR21631 (ISOCITRATE LYASE/MALATE SYNTHASE)
3. PF00463 (ICL)
  
  28 - 549
  
  Pfam
  PF00463 (ICL)
4. TIGR01346
  
  28 - 549
  
  TIGRFAMs
  TIGR01346 (TIGR01346)
IPR039556

ICL/PEPM domain
1. cd00377 (ICL_PEPM)
  
  72 - 487
  
  CDD
  cd00377 (ICL_PEPM)
IPR018523

Isocitrate lyase/phosphorylmutase, conserved site
1. PS00161 (ISOCITRATE...)
  
  217 - 222
  
  PROSITE patterns
  PS00161 (ISOCITRATE_LYASE)

no IPR

Unintegrated signatures

G3DSA:1.10.10...

268 - 375

GENE3D
G3DSA:1.10.10.850 (G3DSA:1.10.10.850)

Residue annotation

tetramer interface...

74N

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

85A

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

87R

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

88T

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

89F

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

90G

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

92L

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

93D

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

94P

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

95V

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

96Q

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

98A

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

99Q

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

102K

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

104L

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

105D

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

112W

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

116S

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

117T

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

125G

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

126P

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

129A

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

130D

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

131Y

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

132P

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

134D

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

135T

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

138N

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

139K

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

141Q

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

142H

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

145L

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

146A

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

187G

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

193I

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

194K

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

198M

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

201E

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

231T

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

232E

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

235N

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

238I

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

239A

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

242L

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

476A

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

477N

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

478A

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

480M

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

481V

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

482D

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

484F

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

485A

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)

486K

tetramer interface
74N, 85A, 87R, 88T, 89F, 90G, 92L, 93D, 94P, 95V, 96Q, 98A, 99Q, 102K, 104L, 105D, 112W, 116S, 117T, 125G, 126P, 129A, 130D, 131Y, 132P, 134D, 135T, 138N, 139K, 141Q, 142H, 145L, 146A, 187G, 193I, 194K, 198M, 201E, 231T, 232E, 235N, 238I, 239A, 242L, 476A, 477N, 478A, 480M, 481V, 482D, 484F, 485A, 486K
CDD
cd00377 (ICL_PEPM)
active site cd00377

108Y

active site
108Y, 110S, 111G, 112W, 127D, 181D, 183D, 210E, 256R, 407E, 435N, 437S, 470T
CDD
cd00377 (ICL_PEPM)

110S

active site
108Y, 110S, 111G, 112W, 127D, 181D, 183D, 210E, 256R, 407E, 435N, 437S, 470T
CDD
cd00377 (ICL_PEPM)

111G

active site
108Y, 110S, 111G, 112W, 127D, 181D, 183D, 210E, 256R, 407E, 435N, 437S, 470T
CDD
cd00377 (ICL_PEPM)

112W

active site
108Y, 110S, 111G, 112W, 127D, 181D, 183D, 210E, 256R, 407E, 435N, 437S, 470T
CDD
cd00377 (ICL_PEPM)

127D

active site
108Y, 110S, 111G, 112W, 127D, 181D, 183D, 210E, 256R, 407E, 435N, 437S, 470T
CDD
cd00377 (ICL_PEPM)

181D

active site
108Y, 110S, 111G, 112W, 127D, 181D, 183D, 210E, 256R, 407E, 435N, 437S, 470T
CDD
cd00377 (ICL_PEPM)

183D

active site
108Y, 110S, 111G, 112W, 127D, 181D, 183D, 210E, 256R, 407E, 435N, 437S, 470T
CDD
cd00377 (ICL_PEPM)

210E

active site
108Y, 110S, 111G, 112W, 127D, 181D, 183D, 210E, 256R, 407E, 435N, 437S, 470T
CDD
cd00377 (ICL_PEPM)

256R

active site
108Y, 110S, 111G, 112W, 127D, 181D, 183D, 210E, 256R, 407E, 435N, 437S, 470T
CDD
cd00377 (ICL_PEPM)

407E

active site
108Y, 110S, 111G, 112W, 127D, 181D, 183D, 210E, 256R, 407E, 435N, 437S, 470T
CDD
cd00377 (ICL_PEPM)

435N

active site
108Y, 110S, 111G, 112W, 127D, 181D, 183D, 210E, 256R, 407E, 435N, 437S, 470T
CDD
cd00377 (ICL_PEPM)

437S

active site
108Y, 110S, 111G, 112W, 127D, 181D, 183D, 210E, 256R, 407E, 435N, 437S, 470T
CDD
cd00377 (ICL_PEPM)

470T

active site
108Y, 110S, 111G, 112W, 127D, 181D, 183D, 210E, 256R, 407E, 435N, 437S, 470T
CDD
cd00377 (ICL_PEPM)
Mg2+/Mn2+ binding ...

127D

Mg2+/Mn2+ binding site
127D, 181D, 183D, 210E
CDD
cd00377 (ICL_PEPM)

181D

Mg2+/Mn2+ binding site
127D, 181D, 183D, 210E
CDD
cd00377 (ICL_PEPM)

183D

Mg2+/Mn2+ binding site
127D, 181D, 183D, 210E
CDD
cd00377 (ICL_PEPM)

210E

Mg2+/Mn2+ binding site
127D, 181D, 183D, 210E
CDD
cd00377 (ICL_PEPM)

GO term prediction

Biological Process

GO:0019752 carboxylic acid metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004451 isocitrate lyase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features