Mp2g20660.1

Protein

Length

2,083 amino acids

Protein family membership

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase (IPR004433)

Isochorismate synthase (IPR004561)

Homologous superfamilies

Homologous superfamily
135 - 672
ADC synthase (IPR005801)
674 - 853
Thiamin diphosphate-binding fold (IPR029061)
891 - 1,056
DHS-like NAD/FAD-binding domain superfamily (IPR029035)
1,074 - 1,268
Thiamin diphosphate-binding fold (IPR029061)
1,316 - 1,449
Enolase-like, N-terminal (IPR029017)
1,459 - 1,707
Enolase-like, C-terminal domain superfamily (IPR036849)
1,746 - 2,073
Alpha/Beta hydrolase fold (IPR029058)

1 200 400 600 800 1000 1200 1400 1600 1800 2083

Domains and repeats

Domain
371 - 579
Chorismate-utilising enzyme, C-terminal (IPR015890)
683 - 843
Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain (IPR012001)
863 - 1,097
Menaquinone biosynthesis protein MenD, middle domain (IPR032264)
1,148 - 1,267
Thiamine pyrophosphate enzyme, C-terminal TPP-binding (IPR011766)
1,480 - 1,652
Enolase C-terminal domain-like (IPR029065)
1,769 - 2,067
Alpha/beta hydrolase fold-1 (IPR000073)
Domain
1,477 - 1,573
Mandelate racemase/muconate lactonizing enzyme, C-terminal (IPR013342)

1 200 400 600 800 1000 1200 1400 1600 1800 2083

Detailed signature matches

IPR005801

ADC synthase
1. SSF56322 (ADC synthase)
  
  634 - 667
  
  SUPERFAMILY
  SSF56322 (ADC synthase)
  
  228 - 581
  
  SUPERFAMILY
  SSF56322 (ADC synthase)
2. G3DSA:3.60.12... (A...)
  
  135 - 583
  
  GENE3D
  G3DSA:3.60.120.10 (Anthranilate synthase)
  
  626 - 672
  
  GENE3D
  G3DSA:3.60.120.10 (Anthranilate synthase)
IPR029061

Thiamin diphosphate-binding fold
1. SSF52518 (Thiamin d...)
  
  674 - 853
  
  SUPERFAMILY
  SSF52518 (Thiamin diphosphate-binding fold (THDP-binding))
  
  1,074 - 1,268
  
  SUPERFAMILY
  SSF52518 (Thiamin diphosphate-binding fold (THDP-binding))
IPR029035

DHS-like NAD/FAD-binding domain superfamily
1. SSF52467 (DHS-like ...)
  
  891 - 1,056
  
  SUPERFAMILY
  SSF52467 (DHS-like NAD/FAD-binding domain)
IPR029017

Enolase-like, N-terminal
1. SSF54826 (Enolase N...)
  
  1,318 - 1,436
  
  SUPERFAMILY
  SSF54826 (Enolase N-terminal domain-like)
2. G3DSA:3.30.39...
  
  1,316 - 1,449
  
  GENE3D
  G3DSA:3.30.390.10 (G3DSA:3.30.390.10)
IPR036849

Enolase-like, C-terminal domain superfamily
1. G3DSA:3.20.20... (E...)
  
  1,459 - 1,707
  
  GENE3D
  G3DSA:3.20.20.120 (Enolase superfamily)
2. SSF51604 (Enolase C...)
  
  1,462 - 1,655
  
  SUPERFAMILY
  SSF51604 (Enolase C-terminal domain-like)
IPR029058

Alpha/Beta hydrolase fold
1. SSF53474 (alpha/bet...)
  
  2,041 - 2,073
  
  SUPERFAMILY
  SSF53474 (alpha/beta-Hydrolases)
  
  1,746 - 1,997
  
  SUPERFAMILY
  SSF53474 (alpha/beta-Hydrolases)
IPR004433

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase
1. PTHR42916 (2-SUCCIN...)
  
  211 - 2,076
  
  PANTHER
  PTHR42916 (2-SUCCINYL-5-ENOLPYRUVYL-6-HYDROXY-3-CYCLOHEXENE-1-CARBOXYLATE SYNTHASE)
2. TIGR00173
  
  682 - 1,157
  
  TIGRFAMs
  TIGR00173 (TIGR00173)
3. MF_01659 (MenD)
  
  676 - 1,286
  
  HAMAP
  MF_01659 (MenD)
IPR004561

Isochorismate synthase
1. TIGR00543
  
  245 - 579
  
  TIGRFAMs
  TIGR00543 (TIGR00543)
IPR015890

Chorismate-utilising enzyme, C-terminal
1. PF00425 (Chorismate...)
  
  371 - 579
  
  Pfam
  PF00425 (Chorismate_bind)
IPR012001

Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
1. PF02776 (TPP_enzyme_N)
  
  683 - 843
  
  Pfam
  PF02776 (TPP_enzyme_N)
IPR032264

Menaquinone biosynthesis protein MenD, middle domain
1. PF16582 (TPP_enzyme...)
  
  863 - 1,097
  
  Pfam
  PF16582 (TPP_enzyme_M_2)
IPR011766

Thiamine pyrophosphate enzyme, C-terminal TPP-binding
1. PF02775 (TPP_enzyme_C)
  
  1,148 - 1,267
  
  Pfam
  PF02775 (TPP_enzyme_C)
IPR013342

Mandelate racemase/muconate lactonizing enzyme, C-terminal
1. SM00922 (MR_MLE_2)
  
  1,477 - 1,573
  
  SMART
  SM00922 (MR_MLE_2)
IPR029065

Enolase C-terminal domain-like
1. PF13378 (MR_MLE_C)
  
  1,480 - 1,652
  
  Pfam
  PF13378 (MR_MLE_C)
IPR000073

Alpha/beta hydrolase fold-1
1. PF12697 (Abhydrolase_6)
  
  1,769 - 2,067
  
  Pfam
  PF12697 (Abhydrolase_6)
IPR018110

Mandelate racemase/muconate lactonizing enzyme, conserved site
1. PS00909 (MR_MLE_2)
  
  1,525 - 1,556
  
  PROSITE patterns
  PS00909 (MR_MLE_2)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

888 - 1,068

GENE3D
G3DSA:3.40.50.1220 (G3DSA:3.40.50.1220)
G3DSA:3.40.50...

674 - 871

GENE3D
G3DSA:3.40.50.970 (G3DSA:3.40.50.970)

1,075 - 1,296

GENE3D
G3DSA:3.40.50.970 (G3DSA:3.40.50.970)
SFLDF00009 (o-succi...)

1,315 - 1,692

SFLD
SFLDF00009 (o-succinylbenzoate_synthase)
SFLDG00180 (muconat...)

1,315 - 1,692

SFLD
SFLDG00180 (muconate_cycloisomerase)
TIGR01927

1,342 - 1,651

TIGRFAMs
TIGR01927 (TIGR01927)
cd02009 (TPP_SHCHC_...)

1,076 - 1,270

CDD
cd02009 (TPP_SHCHC_synthase)
cd07037 (TPP_PYR_MenD)

685 - 845

CDD
cd07037 (TPP_PYR_MenD)

Other features

mobidb-lite (disord...)

2,000 - 2,036

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Polar)

2,006 - 2,031

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

Residue annotation

PYR/PP interface c...

700I

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

702P

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

703G

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

707S

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

721C

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

722V

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

723P

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

724C

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

725I

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

726D

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

727E

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

728R

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

729S

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

732F

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

733H

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

735V

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

736G

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

737Y

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

739R

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

740G

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

753T

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

757N

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

760P

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

764E

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

767Q

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

789N

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)

790Q

PYR/PP interface
700I, 702P, 703G, 707S, 721C, 722V, 723P, 724C, 725I, 726D, 727E, 728R, 729S, 732F, 733H, 735V, 736G, 737Y, 739R, 740G, 753T, 757N, 760P, 764E, 767Q, 789N, 790Q
CDD
cd07037 (TPP_PYR_MenD)
dimer interface cd...

700I

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

702P

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

703G

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

707S

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

721C

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

723P

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

724C

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

725I

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

726D

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

727E

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

728R

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

753T

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

756S

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

757N

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

759L

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

760P

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

763V

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

782E

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

789N

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

790Q

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

793D

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

797H

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

800G

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

801F

dimer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)
tetramer interface...

700I

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

702P

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

703G

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

707S

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

721C

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

723P

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

724C

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

725I

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

726D

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

727E

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

728R

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

753T

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

756S

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

757N

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

759L

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

760P

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

763V

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

782E

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

789N

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

790Q

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

793D

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

797H

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

800G

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)

801F

tetramer interface
700I, 702P, 703G, 707S, 721C, 723P, 724C, 725I, 726D, 727E, 728R, 753T, 756S, 757N, 759L, 760P, 763V, 782E, 789N, 790Q, 793D, 797H, 800G, 801F
CDD
cd07037 (TPP_PYR_MenD)
TPP binding site c...

727E

TPP binding site
727E
CDD
cd07037 (TPP_PYR_MenD)
TPP-binding site c...

1,145I

TPP-binding site
1,145I, 1,168G, 1,169D, 1,170V, 1,171S, 1,198N, 1,200G
CDD
cd02009 (TPP_SHCHC_synthase)

1,168G

TPP-binding site
1,145I, 1,168G, 1,169D, 1,170V, 1,171S, 1,198N, 1,200G
CDD
cd02009 (TPP_SHCHC_synthase)

1,169D

TPP-binding site
1,145I, 1,168G, 1,169D, 1,170V, 1,171S, 1,198N, 1,200G
CDD
cd02009 (TPP_SHCHC_synthase)

1,170V

TPP-binding site
1,145I, 1,168G, 1,169D, 1,170V, 1,171S, 1,198N, 1,200G
CDD
cd02009 (TPP_SHCHC_synthase)

1,171S

TPP-binding site
1,145I, 1,168G, 1,169D, 1,170V, 1,171S, 1,198N, 1,200G
CDD
cd02009 (TPP_SHCHC_synthase)

1,198N

TPP-binding site
1,145I, 1,168G, 1,169D, 1,170V, 1,171S, 1,198N, 1,200G
CDD
cd02009 (TPP_SHCHC_synthase)

1,200G

TPP-binding site
1,145I, 1,168G, 1,169D, 1,170V, 1,171S, 1,198N, 1,200G
CDD
cd02009 (TPP_SHCHC_synthase)
SFLDF00009

1,498K

base (abstracts alpha proton), acid (donates proton to leaving group)
1,498K
SFLD
SFLDF00009 (o-succinylbenzoate_synthase)
SFLDF00009

1,528D

metal binding ligand
1,528D, 1,554E, 1,577D
SFLD
SFLDF00009 (o-succinylbenzoate_synthase)

1,554E

metal binding ligand
1,528D, 1,554E, 1,577D
SFLD
SFLDF00009 (o-succinylbenzoate_synthase)

1,577D

metal binding ligand
1,528D, 1,554E, 1,577D
SFLD
SFLDF00009 (o-succinylbenzoate_synthase)
SFLDF00009

1,605K

stabilizes intermediate through cation-pi interaction
1,605K
SFLD
SFLDF00009 (o-succinylbenzoate_synthase)

GO term prediction

Biological Process

GO:0009058 biosynthetic process
GO:0009063 cellular amino acid catabolic process
GO:0009234 menaquinone biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0008909 isochorismate synthase activity
GO:0030976 thiamine pyrophosphate binding
GO:0070204 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features