Mp2g25720.1

Protein

Length

2,072 amino acids

Protein family membership

Transcription elongation factor Spt6 (IPR017072)

Homologous superfamilies

Homologous superfamily
322 - 498
Tex-like protein, HTH domain superfamily (IPR023319)
756 - 912
Ribonuclease H-like superfamily (IPR012337)
926 - 1,018
RuvA domain 2-like (IPR010994)
1,031 - 1,123
RuvA domain 2-like (IPR010994)
1,144 - 1,222
Nucleic acid-binding, OB-fold (IPR012340)
1,256 - 1,366
SH2 domain superfamily (IPR036860)
Homologous superfamily
499 - 949
Tex-like domain superfamily (IPR023323)
1,021 - 1,122
Spt6, Death-like domain (IPR042066)
Homologous superfamily
746 - 1,141
YqgF/RNase H-like domain superfamily (IPR037027)

1 200 400 600 800 1000 1200 1400 1600 1800 2072

Domains and repeats

Domain
30 - 127
Spt6 acidic, N-terminal domain (IPR028083)
329 - 451
Helix-turn-helix DNA-binding domain of Spt6 (IPR028088)
756 - 911
YqgF/RNase H-like domain (IPR006641)
Transcription elongation factor Spt6, YqgF domain (IPR028231)
915 - 1,017
Transcription elongation factor Spt6, helix-hairpin-helix motif (IPR032706)
1,031 - 1,059
HHH domain 9 (IPR041692)
1,147 - 1,218
RNA-binding domain, S1 (IPR022967)
S1 domain (IPR003029)
1,244 - 1,456
Spt6, SH2 domain (IPR035420)
Spt6, SH2 domain, N terminus (IPR035019)
Spt6, SH2 domain, C terminus (IPR035018)

1 200 400 600 800 1000 1200 1400 1600 1800 2072

Detailed signature matches

IPR023319

Tex-like protein, HTH domain superfamily
1. G3DSA:1.10.10...
  
  322 - 498
  
  GENE3D
  G3DSA:1.10.10.650 (G3DSA:1.10.10.650)
IPR023323

Tex-like domain superfamily
1. G3DSA:1.10.35...
  
  499 - 745
  
  GENE3D
  G3DSA:1.10.3500.10 (G3DSA:1.10.3500.10)
  
  903 - 949
  
  GENE3D
  G3DSA:1.10.3500.10 (G3DSA:1.10.3500.10)
IPR037027

YqgF/RNase H-like domain superfamily
1. G3DSA:3.30.42...
  
  1,123 - 1,141
  
  GENE3D
  G3DSA:3.30.420.140 (G3DSA:3.30.420.140)
  
  746 - 902
  
  GENE3D
  G3DSA:3.30.420.140 (G3DSA:3.30.420.140)
IPR012337

Ribonuclease H-like superfamily
1. SSF53098 (Ribonucle...)
  
  756 - 912
  
  SUPERFAMILY
  SSF53098 (Ribonuclease H-like)
IPR010994

RuvA domain 2-like
1. SSF47781 (RuvA doma...)
  
  926 - 1,018
  
  SUPERFAMILY
  SSF47781 (RuvA domain 2-like)
  
  1,031 - 1,123
  
  SUPERFAMILY
  SSF47781 (RuvA domain 2-like)
IPR042066

Spt6, Death-like domain
1. G3DSA:1.10.10...
  
  1,021 - 1,122
  
  GENE3D
  G3DSA:1.10.10.2740 (G3DSA:1.10.10.2740)
IPR012340

Nucleic acid-binding, OB-fold
1. SSF50249 (Nucleic a...)
  
  1,144 - 1,222
  
  SUPERFAMILY
  SSF50249 (Nucleic acid-binding proteins)
IPR036860

SH2 domain superfamily
1. SSF55550 (SH2 domain)
  
  1,274 - 1,359
  
  SUPERFAMILY
  SSF55550 (SH2 domain)
2. G3DSA:3.30.50... (S...)
  
  1,256 - 1,366
  
  GENE3D
  G3DSA:3.30.505.10 (SHC Adaptor Protein)
IPR017072

Transcription elongation factor Spt6
1. PTHR10145 (TRANSCRI...)
  
  9 - 1,527
  
  PANTHER
  PTHR10145 (TRANSCRIPTION ELONGATION FACTOR SPT6)
IPR028083

Spt6 acidic, N-terminal domain
1. PF14632 (SPT6_acidic)
  
  30 - 127
  
  Pfam
  PF14632 (SPT6_acidic)
IPR028088

Helix-turn-helix DNA-binding domain of Spt6
1. PF14641 (HTH_44)
  
  329 - 451
  
  Pfam
  PF14641 (HTH_44)
IPR006641

YqgF/RNase H-like domain
1. SM00732 (rnase_8s)
  
  756 - 874
  
  SMART
  SM00732 (rnase_8s)
IPR028231

Transcription elongation factor Spt6, YqgF domain
1. PF14639 (YqgF)
  
  756 - 911
  
  Pfam
  PF14639 (YqgF)
IPR032706

Transcription elongation factor Spt6, helix-hairpin-helix motif
1. PF14635 (HHH_7)
  
  915 - 1,017
  
  Pfam
  PF14635 (HHH_7)
IPR041692

HHH domain 9
1. PF17674 (HHH_9)
  
  1,031 - 1,059
  
  Pfam
  PF17674 (HHH_9)
IPR022967

RNA-binding domain, S1
1. SM00316 (S1_6)
  
  1,147 - 1,218
  
  SMART
  SM00316 (S1_6)
IPR003029

S1 domain
1. PS50126 (S1)
  
  1,149 - 1,218
  
  PROSITE profiles
  PS50126 (S1)
IPR035420

Spt6, SH2 domain
1. PF14633 (SH2_2)
  
  1,244 - 1,455
  
  Pfam
  PF14633 (SH2_2)
IPR035019

Spt6, SH2 domain, N terminus
1. cd09918 (SH2_Nterm_...)
  
  1,270 - 1,358
  
  CDD
  cd09918 (SH2_Nterm_SPT6_like)
IPR035018

Spt6, SH2 domain, C terminus
1. cd09928 (SH2_Cterm_...)
  
  1,369 - 1,456
  
  CDD
  cd09928 (SH2_Cterm_SPT6_like)

no IPR

Unintegrated signatures

G3DSA:1.10.15...

289 - 321

GENE3D
G3DSA:1.10.150.850 (G3DSA:1.10.150.850)

950 - 1,020

GENE3D
G3DSA:1.10.150.850 (G3DSA:1.10.150.850)
G3DSA:2.40.50...

1,142 - 1,221

GENE3D
G3DSA:2.40.50.140 (G3DSA:2.40.50.140)
SSF158832 (Tex N-te...)

366 - 736

SUPERFAMILY
SSF158832 (Tex N-terminal region-like)
cd00164 (S1_like)

1,152 - 1,208

CDD
cd00164 (S1_like)

Other features

Coil

27 - 47

COILS
Coil (Coil)
mobidb-lite (disord...)

258 - 278

MobiDB Lite
mobidb-lite (disorder_prediction)

1,474 - 1,540

MobiDB Lite
mobidb-lite (disorder_prediction)

1,610 - 2,072

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 240

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Negati...)

175 - 210

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Negative Polyelectrolyte

8 - 68

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Negative Polyelectrolyte
mobidb-lite (Polyam...)

150 - 172

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

125 - 142

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

1,927 - 1,959

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte
mobidb-lite (Prolin...)

2,000 - 2,017

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Proline-rich
mobidb-lite (Polar)

1,617 - 1,638

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

1,973 - 1,997

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

1,658 - 1,686

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

1,854 - 1,874

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

1,740 - 1,769

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

1,811 - 1,840

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

1,776 - 1,801

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

Residue annotation

RNA binding site c...

1,157R

RNA binding site
1,157R, 1,165M, 1,175I, 1,177H
CDD
cd00164 (S1_like)

1,165M

RNA binding site
1,157R, 1,165M, 1,175I, 1,177H
CDD
cd00164 (S1_like)

1,175I

RNA binding site
1,157R, 1,165M, 1,175I, 1,177H
CDD
cd00164 (S1_like)

1,177H

RNA binding site
1,157R, 1,165M, 1,175I, 1,177H
CDD
cd00164 (S1_like)
phosphotyrosine bi...

1,278L

phosphotyrosine binding pocket
1,278L, 1,296R, 1,318N, 1,320D
CDD
cd09918 (SH2_Nterm_SPT6_like)

1,296R

phosphotyrosine binding pocket
1,278L, 1,296R, 1,318N, 1,320D
CDD
cd09918 (SH2_Nterm_SPT6_like)

1,318N

phosphotyrosine binding pocket
1,278L, 1,296R, 1,318N, 1,320D
CDD
cd09918 (SH2_Nterm_SPT6_like)

1,320D

phosphotyrosine binding pocket
1,278L, 1,296R, 1,318N, 1,320D
CDD
cd09918 (SH2_Nterm_SPT6_like)
hydrophobic bindin...

1,319I

hydrophobic binding pocket
1,319I, 1,358Y
CDD
cd09918 (SH2_Nterm_SPT6_like)

1,358Y

hydrophobic binding pocket
1,319I, 1,358Y
CDD
cd09918 (SH2_Nterm_SPT6_like)
phosphotyrosine bi...

1,380K

phosphotyrosine binding pocket
1,380K, 1,403S, 1,425H, 1,427Y
CDD
cd09928 (SH2_Cterm_SPT6_like)

1,403S

phosphotyrosine binding pocket
1,380K, 1,403S, 1,425H, 1,427Y
CDD
cd09928 (SH2_Cterm_SPT6_like)

1,425H

phosphotyrosine binding pocket
1,380K, 1,403S, 1,425H, 1,427Y
CDD
cd09928 (SH2_Cterm_SPT6_like)

1,427Y

phosphotyrosine binding pocket
1,380K, 1,403S, 1,425H, 1,427Y
CDD
cd09928 (SH2_Cterm_SPT6_like)
hydrophobic bindin...

1,426E

hydrophobic binding pocket
1,426E, 1,452F
CDD
cd09928 (SH2_Cterm_SPT6_like)

1,452F

hydrophobic binding pocket
1,426E, 1,452F
CDD
cd09928 (SH2_Cterm_SPT6_like)

GO term prediction

Biological Process

GO:0006139 nucleobase-containing compound metabolic process
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter

Molecular Function

GO:0003676 nucleic acid binding
GO:0003677 DNA binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features