Mp3g19090.1

Protein

Length

956 amino acids

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily IIIA (IPR006534)

Homologous superfamilies

Homologous superfamily
21 - 853
P-type ATPase, transmembrane domain superfamily (IPR023298)
Homologous superfamily
138 - 235
P-type ATPase, A domain superfamily (IPR008250)
350 - 491
P-type ATPase, cytoplasmic domain N (IPR023299)
492 - 554
HAD superfamily (IPR023214)
Homologous superfamily
331 - 641
HAD-like superfamily (IPR036412)

1 100 200 300 400 500 600 700 800 900 956

Domains and repeats

Domain
21 - 93
Cation-transporting P-type ATPase, N-terminal (IPR004014)
317 - 645
P-type ATPase, haloacid dehalogenase domain (IPR044492)

1 100 200 300 400 500 600 700 800 900 956

Detailed signature matches

IPR023298

P-type ATPase, transmembrane domain superfamily
1. SSF81665 (Calcium A...)
  
  643 - 853
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  21 - 138
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  
  235 - 329
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
IPR008250

P-type ATPase, A domain superfamily
1. SSF81653 (Calcium A...)
  
  138 - 235
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
IPR036412

HAD-like superfamily
1. SSF56784 (HAD-like)
  
  331 - 641
  
  SUPERFAMILY
  SSF56784 (HAD-like)
IPR023299

P-type ATPase, cytoplasmic domain N
1. G3DSA:3.40.11...
  
  350 - 491
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
IPR023214

HAD superfamily
1. G3DSA:3.40.50...
  
  492 - 554
  
  GENE3D
  G3DSA:3.40.50.1000 (G3DSA:3.40.50.1000)
IPR001757

P-type ATPase
1. TIGR01494
  
  569 - 678
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
  
  107 - 542
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
2. PR00120 (HATPASE)
  
  451 - 469
  
  PRINTS
  PR00120 (HATPASE)
  
  594 - 610
  
  PRINTS
  PR00120 (HATPASE)
  
  766 - 787
  
  PRINTS
  PR00120 (HATPASE)
  
  566 - 582
  
  PRINTS
  PR00120 (HATPASE)
  
  625 - 650
  
  PRINTS
  PR00120 (HATPASE)
IPR006534

P-type ATPase, subfamily IIIA
1. TIGR01647
  
  40 - 812
  
  TIGRFAMs
  TIGR01647 (TIGR01647)
2. cd02076 (P-type_ATP...)
  
  40 - 847
  
  CDD
  cd02076 (P-type_ATPase_H)
IPR004014

Cation-transporting P-type ATPase, N-terminal
1. PF00690 (Cation_ATP...)
  
  24 - 87
  
  Pfam
  PF00690 (Cation_ATPase_N)
2. SM00831 (Cation_ATP...)
  
  21 - 93
  
  SMART
  SM00831 (Cation_ATPase_N_a_2)
IPR044492

P-type ATPase, haloacid dehalogenase domain
1. SFLDF00027 (p-type_...)
  
  317 - 645
  
  SFLD
  SFLDF00027 (p-type_atpase)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  337 - 343
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

G3DSA:1.20.11...

191 - 349

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)

577 - 852

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)

70 - 164

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
PF00122 (E1-E2_ATPase)

136 - 314

Pfam
PF00122 (E1-E2_ATPase)
PF00702 (Hydrolase)

331 - 608

Pfam
PF00702 (Hydrolase)
PR00119 (CATATPASE)

617 - 629

PRINTS
PR00119 (CATATPASE)

511 - 521

PRINTS
PR00119 (CATATPASE)

489 - 500

PRINTS
PR00119 (CATATPASE)

335 - 349

PRINTS
PR00119 (CATATPASE)

185 - 199

PRINTS
PR00119 (CATATPASE)

594 - 613

PRINTS
PR00119 (CATATPASE)
PTHR42861 (CALCIUM-...)

12 - 936

PANTHER
PTHR42861 (CALCIUM-TRANSPORTING ATPASE)
PTHR42861:SF83 (PLA...)

12 - 936

PANTHER
PTHR42861:SF83 (PLASMA MEMBRANE ATPASE)
SFLDS00003 (Haloaci...)

317 - 645

SFLD
SFLDS00003 (Haloacid_Dehalogenase)

Residue annotation

SFLDF00027

337D

nucleophile: attacks gamma phosphate moiety of ATP to form covalent intermediate, Mg2+ ligand
337D
SFLD
SFLDF00027 (p-type_atpase)
ATP binding site c...

337D

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

338K

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

339T

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

382I

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

383D

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

408F

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

413K

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

415T

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

431K

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

432G

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

464R

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

465S

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

518I

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

519T

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

520G

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

521D

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

571G

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

577K

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

596D

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)

599N

ATP binding site
337D, 338K, 339T, 382I, 383D, 408F, 413K, 415T, 431K, 432G, 464R, 465S, 518I, 519T, 520G, 521D, 571G, 577K, 596D, 599N
CDD
cd02076 (P-type_ATPase_H)
SFLDF00027

338K

probable role in phosphate transfer from ATP
338K
SFLD
SFLDF00027 (p-type_atpase)
SFLDF00027

339T

conserved in all p-type atpases
339T, 340G, 341T
SFLD
SFLDF00027 (p-type_atpase)

340G

conserved in all p-type atpases
339T, 340G, 341T
SFLD
SFLDF00027 (p-type_atpase)

341T

conserved in all p-type atpases
339T, 340G, 341T
SFLD
SFLDF00027 (p-type_atpase)
SFLDF00027

519T

coordinates with phosphate oxygen from ATP
519T
SFLD
SFLDF00027 (p-type_atpase)
SFLDF00027

577K

stabilizes transition state of phosphoryl transfer by contacting beta & gamma phosphate oxygens of ATP
577K
SFLD
SFLDF00027 (p-type_atpase)
SFLDF00027

596D

Mg2+ ligand
596D, 600D
SFLD
SFLDF00027 (p-type_atpase)

600D

Mg2+ ligand
596D, 600D
SFLD
SFLDF00027 (p-type_atpase)
proton binding sit...

656Y

proton binding site
656Y, 657A, 661T, 663R, 692D, 773S
CDD
cd02076 (P-type_ATPase_H)

657A

proton binding site
656Y, 657A, 661T, 663R, 692D, 773S
CDD
cd02076 (P-type_ATPase_H)

661T

proton binding site
656Y, 657A, 661T, 663R, 692D, 773S
CDD
cd02076 (P-type_ATPase_H)

663R

proton binding site
656Y, 657A, 661T, 663R, 692D, 773S
CDD
cd02076 (P-type_ATPase_H)

692D

proton binding site
656Y, 657A, 661T, 663R, 692D, 773S
CDD
cd02076 (P-type_ATPase_H)

773S

proton binding site
656Y, 657A, 661T, 663R, 692D, 773S
CDD
cd02076 (P-type_ATPase_H)

GO term prediction

Biological Process

GO:0120029 proton export across plasma membrane

Molecular Function

GO:0000166 nucleotide binding
GO:0008553 proton-exporting ATPase activity, phosphorylative mechanism

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features