Mp7g17540.1

Protein

Length

196 amino acids

Protein family membership

Small GTPase (IPR001806)
- Small GTPase Rho (IPR003578)

Homologous superfamilies

Homologous superfamily
6 - 178
P-loop containing nucleoside triphosphate hydrolase (IPR027417)

1 20 40 60 80 100 120 140 160 180 196

Domains and repeats

Domain
7 - 171
Small GTP-binding protein domain (IPR005225)

1 20 40 60 80 100 120 140 160 180 196

Detailed signature matches

IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  6 - 178
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR001806

Small GTPase
1. PF00071 (Ras)
  
  8 - 178
  
  Pfam
  PF00071 (Ras)
IPR003578

Small GTPase Rho
1. PS51420 (RHO)
  
  1 - 177
  
  PROSITE profiles
  PS51420 (RHO)
IPR005225

Small GTP-binding protein domain
1. TIGR00231
  
  7 - 171
  
  TIGRFAMs
  TIGR00231 (TIGR00231)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

3 - 183

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
PR00449 (RASTRNSFRMNG)

30 - 46

PRINTS
PR00449 (RASTRNSFRMNG)

109 - 122

PRINTS
PR00449 (RASTRNSFRMNG)

47 - 69

PRINTS
PR00449 (RASTRNSFRMNG)

155 - 177

PRINTS
PR00449 (RASTRNSFRMNG)

7 - 28

PRINTS
PR00449 (RASTRNSFRMNG)
PTHR24072 (RHO FAMI...)

1 - 196

PANTHER
PTHR24072 (RHO FAMILY GTPASE)
PTHR24072:SF336 (RA...)

1 - 196

PANTHER
PTHR24072:SF336 (RAC-LIKE GTP-BINDING PROTEIN 5)
SM00173 (ras_sub_4)

4 - 180

SMART
SM00173 (ras_sub_4)
SM00174 (rho_sub_3)

9 - 180

SMART
SM00174 (rho_sub_3)
SM00175 (rab_sub_5)

7 - 180

SMART
SM00175 (rab_sub_5)
cd04133 (Rop_like)

6 - 178

CDD
cd04133 (Rop_like)

Residue annotation

putative GEF (guan...

8K

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

38T

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

39V

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

41D

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

42N

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

44S

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

46N

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

55N

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

59W

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

60D

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

62A

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

63G

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

64Q

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

70L

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)

73L

putative GEF (guanine nucleotide exchange factor) interaction site
8K, 38T, 39V, 41D, 42N, 44S, 46N, 55N, 59W, 60D, 62A, 63G, 64Q, 70L, 73L
CDD
cd04133 (Rop_like)
G1 box cd04133

13G

G1 box
13G, 14D, 15G, 16A, 17V, 18G, 19K, 20T
CDD
cd04133 (Rop_like)

14D

G1 box
13G, 14D, 15G, 16A, 17V, 18G, 19K, 20T
CDD
cd04133 (Rop_like)

15G

G1 box
13G, 14D, 15G, 16A, 17V, 18G, 19K, 20T
CDD
cd04133 (Rop_like)

16A

G1 box
13G, 14D, 15G, 16A, 17V, 18G, 19K, 20T
CDD
cd04133 (Rop_like)

17V

G1 box
13G, 14D, 15G, 16A, 17V, 18G, 19K, 20T
CDD
cd04133 (Rop_like)

18G

G1 box
13G, 14D, 15G, 16A, 17V, 18G, 19K, 20T
CDD
cd04133 (Rop_like)

19K

G1 box
13G, 14D, 15G, 16A, 17V, 18G, 19K, 20T
CDD
cd04133 (Rop_like)

20T

G1 box
13G, 14D, 15G, 16A, 17V, 18G, 19K, 20T
CDD
cd04133 (Rop_like)
GTP/Mg2+ binding s...

16A

GTP/Mg2+ binding site
16A, 17V, 18G, 19K, 20T, 21C, 60D, 61T, 63G, 119K, 121D, 160S, 161K
CDD
cd04133 (Rop_like)

17V

GTP/Mg2+ binding site
16A, 17V, 18G, 19K, 20T, 21C, 60D, 61T, 63G, 119K, 121D, 160S, 161K
CDD
cd04133 (Rop_like)

18G

GTP/Mg2+ binding site
16A, 17V, 18G, 19K, 20T, 21C, 60D, 61T, 63G, 119K, 121D, 160S, 161K
CDD
cd04133 (Rop_like)

19K

GTP/Mg2+ binding site
16A, 17V, 18G, 19K, 20T, 21C, 60D, 61T, 63G, 119K, 121D, 160S, 161K
CDD
cd04133 (Rop_like)

20T

GTP/Mg2+ binding site
16A, 17V, 18G, 19K, 20T, 21C, 60D, 61T, 63G, 119K, 121D, 160S, 161K
CDD
cd04133 (Rop_like)

21C

GTP/Mg2+ binding site
16A, 17V, 18G, 19K, 20T, 21C, 60D, 61T, 63G, 119K, 121D, 160S, 161K
CDD
cd04133 (Rop_like)

60D

GTP/Mg2+ binding site
16A, 17V, 18G, 19K, 20T, 21C, 60D, 61T, 63G, 119K, 121D, 160S, 161K
CDD
cd04133 (Rop_like)

61T

GTP/Mg2+ binding site
16A, 17V, 18G, 19K, 20T, 21C, 60D, 61T, 63G, 119K, 121D, 160S, 161K
CDD
cd04133 (Rop_like)

63G

GTP/Mg2+ binding site
16A, 17V, 18G, 19K, 20T, 21C, 60D, 61T, 63G, 119K, 121D, 160S, 161K
CDD
cd04133 (Rop_like)

119K

GTP/Mg2+ binding site
16A, 17V, 18G, 19K, 20T, 21C, 60D, 61T, 63G, 119K, 121D, 160S, 161K
CDD
cd04133 (Rop_like)

121D

GTP/Mg2+ binding site
16A, 17V, 18G, 19K, 20T, 21C, 60D, 61T, 63G, 119K, 121D, 160S, 161K
CDD
cd04133 (Rop_like)

160S

GTP/Mg2+ binding site
16A, 17V, 18G, 19K, 20T, 21C, 60D, 61T, 63G, 119K, 121D, 160S, 161K
CDD
cd04133 (Rop_like)

161K

GTP/Mg2+ binding site
16A, 17V, 18G, 19K, 20T, 21C, 60D, 61T, 63G, 119K, 121D, 160S, 161K
CDD
cd04133 (Rop_like)
Switch I region cd...

37P

Switch I region
37P, 38T, 39V, 40F, 41D, 42N, 43F
CDD
cd04133 (Rop_like)

38T

Switch I region
37P, 38T, 39V, 40F, 41D, 42N, 43F
CDD
cd04133 (Rop_like)

39V

Switch I region
37P, 38T, 39V, 40F, 41D, 42N, 43F
CDD
cd04133 (Rop_like)

40F

Switch I region
37P, 38T, 39V, 40F, 41D, 42N, 43F
CDD
cd04133 (Rop_like)

41D

Switch I region
37P, 38T, 39V, 40F, 41D, 42N, 43F
CDD
cd04133 (Rop_like)

42N

Switch I region
37P, 38T, 39V, 40F, 41D, 42N, 43F
CDD
cd04133 (Rop_like)

43F

Switch I region
37P, 38T, 39V, 40F, 41D, 42N, 43F
CDD
cd04133 (Rop_like)
G2 box cd04133

38T

G2 box
38T
CDD
cd04133 (Rop_like)
putative GAP (GTPa...

39V

putative GAP (GTPase-activating protein) interaction site
39V, 40F, 64Q, 70L
CDD
cd04133 (Rop_like)

40F

putative GAP (GTPase-activating protein) interaction site
39V, 40F, 64Q, 70L
CDD
cd04133 (Rop_like)

64Q

putative GAP (GTPase-activating protein) interaction site
39V, 40F, 64Q, 70L
CDD
cd04133 (Rop_like)

70L

putative GAP (GTPase-activating protein) interaction site
39V, 40F, 64Q, 70L
CDD
cd04133 (Rop_like)
putative GDI (guan...

39V

putative GDI (guanine nucleotide dissociation inhibitor) interaction
39V, 62A, 70L, 72P
CDD
cd04133 (Rop_like)

62A

putative GDI (guanine nucleotide dissociation inhibitor) interaction
39V, 62A, 70L, 72P
CDD
cd04133 (Rop_like)

70L

putative GDI (guanine nucleotide dissociation inhibitor) interaction
39V, 62A, 70L, 72P
CDD
cd04133 (Rop_like)

72P

putative GDI (guanine nucleotide dissociation inhibitor) interaction
39V, 62A, 70L, 72P
CDD
cd04133 (Rop_like)
putative effector ...

40F

putative effector interaction site
40F, 41D, 70L, 73L
CDD
cd04133 (Rop_like)

41D

putative effector interaction site
40F, 41D, 70L, 73L
CDD
cd04133 (Rop_like)

70L

putative effector interaction site
40F, 41D, 70L, 73L
CDD
cd04133 (Rop_like)

73L

putative effector interaction site
40F, 41D, 70L, 73L
CDD
cd04133 (Rop_like)
G3 box cd04133

60D

G3 box
60D, 61T, 62A, 63G
CDD
cd04133 (Rop_like)

61T

G3 box
60D, 61T, 62A, 63G
CDD
cd04133 (Rop_like)

62A

G3 box
60D, 61T, 62A, 63G
CDD
cd04133 (Rop_like)

63G

G3 box
60D, 61T, 62A, 63G
CDD
cd04133 (Rop_like)
Switch II region c...

63G

Switch II region
63G, 64Q, 70L, 71R, 72P, 73L, 78A, 79D, 80V
CDD
cd04133 (Rop_like)

64Q

Switch II region
63G, 64Q, 70L, 71R, 72P, 73L, 78A, 79D, 80V
CDD
cd04133 (Rop_like)

70L

Switch II region
63G, 64Q, 70L, 71R, 72P, 73L, 78A, 79D, 80V
CDD
cd04133 (Rop_like)

71R

Switch II region
63G, 64Q, 70L, 71R, 72P, 73L, 78A, 79D, 80V
CDD
cd04133 (Rop_like)

72P

Switch II region
63G, 64Q, 70L, 71R, 72P, 73L, 78A, 79D, 80V
CDD
cd04133 (Rop_like)

73L

Switch II region
63G, 64Q, 70L, 71R, 72P, 73L, 78A, 79D, 80V
CDD
cd04133 (Rop_like)

78A

Switch II region
63G, 64Q, 70L, 71R, 72P, 73L, 78A, 79D, 80V
CDD
cd04133 (Rop_like)

79D

Switch II region
63G, 64Q, 70L, 71R, 72P, 73L, 78A, 79D, 80V
CDD
cd04133 (Rop_like)

80V

Switch II region
63G, 64Q, 70L, 71R, 72P, 73L, 78A, 79D, 80V
CDD
cd04133 (Rop_like)
G4 box cd04133

118T

G4 box
118T, 119K, 120L, 121D
CDD
cd04133 (Rop_like)

119K

G4 box
118T, 119K, 120L, 121D
CDD
cd04133 (Rop_like)

120L

G4 box
118T, 119K, 120L, 121D
CDD
cd04133 (Rop_like)

121D

G4 box
118T, 119K, 120L, 121D
CDD
cd04133 (Rop_like)
G5 box cd04133

159S

G5 box
159S, 160S, 161K
CDD
cd04133 (Rop_like)

160S

G5 box
159S, 160S, 161K
CDD
cd04133 (Rop_like)

161K

G5 box
159S, 160S, 161K
CDD
cd04133 (Rop_like)

GO term prediction

Biological Process

GO:0007264 small GTPase mediated signal transduction

Molecular Function

GO:0003924 GTPase activity
GO:0005525 GTP binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features