Mp1g05220.1

Protein

Length

699 amino acids

Protein family membership

Aromatic amino acid lyase (IPR001106)
- Phenylalanine ammonia-lyase (IPR005922)

Homologous superfamilies

Homologous superfamily
19 - 254
Fumarase/histidase, N-terminal (IPR024083)
521 - 623
Phenylalanine ammonia-lyase, shielding domain superfamily (IPR023144)
Homologous superfamily
20 - 694
L-Aspartase-like (IPR008948)

1 100 200 300 400 500 600 699

Domains and repeats

None predicted.

Detailed signature matches

IPR024083

Fumarase/histidase, N-terminal
1. G3DSA:1.10.27...
  
  19 - 254
  
  GENE3D
  G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  20 - 694
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR023144

Phenylalanine ammonia-lyase, shielding domain superfamily
1. G3DSA:1.10.27...
  
  521 - 623
  
  GENE3D
  G3DSA:1.10.274.20 (G3DSA:1.10.274.20)
IPR001106

Aromatic amino acid lyase
1. PF00221 (Lyase_arom...)
  
  59 - 530
  
  Pfam
  PF00221 (Lyase_aromatic)
2. PTHR10362 (HISTIDIN...)
  
  17 - 694
  
  PANTHER
  PTHR10362 (HISTIDINE AMMONIA-LYASE)
3. cd00332 (PAL-HAL)
  
  58 - 518
  
  CDD
  cd00332 (PAL-HAL)
IPR005922

Phenylalanine ammonia-lyase
1. TIGR01226
  
  21 - 685
  
  TIGRFAMs
  TIGR01226 (TIGR01226)
IPR022313

Phenylalanine/histidine ammonia-lyases, active site
1. PS00488 (PAL_HISTIDASE)
  
  191 - 207
  
  PROSITE patterns
  PS00488 (PAL_HISTIDASE)

no IPR

Unintegrated signatures

G3DSA:1.20.20... (F...)

630 - 684

GENE3D
G3DSA:1.20.200.10 (Fumarase/aspartase (Central domain))

255 - 520

GENE3D
G3DSA:1.20.200.10 (Fumarase/aspartase (Central domain))
PTHR10362:SF54 (PHE...)

17 - 694

PANTHER
PTHR10362:SF54 (PHENYLALANINE AMMONIA-LYASE)

Other features

Coil

517 - 537

COILS
Coil (Coil)

Residue annotation

active sites cd00332

104Y

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

105G

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

106V

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

108T

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

110F

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

125Q

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

128L

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

244P

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

245K

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

246E

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

247G

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

248L

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

252N

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

343Y

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

346R

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

376N

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)

388H

active sites
104Y, 105G, 106V, 108T, 110F, 125Q, 128L, 244P, 245K, 246E, 247G, 248L, 252N, 343Y, 346R, 376N, 388H
CDD
cd00332 (PAL-HAL)
tetramer interface...

109G

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

110F

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

127E

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

130R

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

131F

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

132L

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

133N

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

134A

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

135G

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

136V

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

137L

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

162Q

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

190R

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

191G

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

204Y

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

207G

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

296L

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

297T

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

300L

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

301K

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

303H

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

306Q

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

340Q

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

342R

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

343Y

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

344A

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

346R

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

347T

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

350Q

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

351W

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

357E

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

358V

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

361A

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

364H

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

365S

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

368R

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

369E

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

372S

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

373V

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

378L

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

379I

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

380D

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

385M

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

387V

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

388H

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

389G

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

390G

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

391N

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

392F

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

393Q

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

395T

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

396P

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

399V

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

403N

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

410A

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

413K

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

417A

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

421E

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

424N

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

427Y

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

442S

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

443L

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

445Y

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

446G

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

448K

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

449G

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

450A

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

451E

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

453A

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

455A

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

456S

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

457Y

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

458C

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

459S

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

460E

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

462L

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

463Y

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

464L

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

465A

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

476E

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

477Q

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

478H

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

479N

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

480Q

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

481D

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

482V

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

485L

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

491R

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

492K

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

495E

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

498E

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

499I

tetramer interface
109G, 110F, 127E, 130R, 131F, 132L, 133N, 134A, 135G, 136V, 137L, 162Q, 190R, 191G, 204Y, 207G, 296L, 297T, 300L, 301K, 303H, 306Q, 340Q, 342R, 343Y, 344A, 346R, 347T, 350Q, 351W, 357E, 358V, 361A, 364H, 365S, 368R, 369E, 372S, 373V, 378L, 379I, 380D, 385M, 387V, 388H, 389G, 390G, 391N, 392F, 393Q, 395T, 396P, 399V, 403N, 410A, 413K, 417A, 421E, 424N, 427Y, 442S, 443L, 445Y, 446G, 448K, 449G, 450A, 451E, 453A, 455A, 456S, 457Y, 458C, 459S, 460E, 462L, 463Y, 464L, 465A, 476E, 477Q, 478H, 479N, 480Q, 481D, 482V, 485L, 491R, 492K, 495E, 498E, 499I
CDD
cd00332 (PAL-HAL)

GO term prediction

Biological Process

GO:0006559 L-phenylalanine catabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0016841 ammonia-lyase activity

Cellular Component

GO:0005737 cytoplasm

Filter view on

Entry type

Status

Per-residue features