Mp1g10150.1

Protein

Length

722 amino acids

Protein family membership

Aromatic amino acid lyase (IPR001106)
- Phenylalanine ammonia-lyase (IPR005922)

Homologous superfamilies

Homologous superfamily
33 - 268
Fumarase/histidase, N-terminal (IPR024083)
535 - 650
Phenylalanine ammonia-lyase, shielding domain superfamily (IPR023144)
Homologous superfamily
34 - 722
L-Aspartase-like (IPR008948)

1 100 200 300 400 500 600 722

Domains and repeats

None predicted.

Detailed signature matches

IPR024083

Fumarase/histidase, N-terminal
1. G3DSA:1.10.27...
  
  33 - 268
  
  GENE3D
  G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  34 - 722
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR023144

Phenylalanine ammonia-lyase, shielding domain superfamily
1. G3DSA:1.10.27...
  
  535 - 650
  
  GENE3D
  G3DSA:1.10.274.20 (G3DSA:1.10.274.20)
IPR001106

Aromatic amino acid lyase
1. PF00221 (Lyase_arom...)
  
  73 - 546
  
  Pfam
  PF00221 (Lyase_aromatic)
2. PTHR10362 (HISTIDIN...)
  
  30 - 721
  
  PANTHER
  PTHR10362 (HISTIDINE AMMONIA-LYASE)
3. cd00332 (PAL-HAL)
  
  72 - 532
  
  CDD
  cd00332 (PAL-HAL)
IPR005922

Phenylalanine ammonia-lyase
1. TIGR01226
  
  34 - 713
  
  TIGRFAMs
  TIGR01226 (TIGR01226)
IPR022313

Phenylalanine/histidine ammonia-lyases, active site
1. PS00488 (PAL_HISTIDASE)
  
  205 - 221
  
  PROSITE patterns
  PS00488 (PAL_HISTIDASE)

no IPR

Unintegrated signatures

G3DSA:1.20.20... (F...)

657 - 712

GENE3D
G3DSA:1.20.200.10 (Fumarase/aspartase (Central domain))

269 - 534

GENE3D
G3DSA:1.20.200.10 (Fumarase/aspartase (Central domain))
PTHR10362:SF54 (PHE...)

30 - 721

PANTHER
PTHR10362:SF54 (PHENYLALANINE AMMONIA-LYASE)

Residue annotation

active sites cd00332

117Y

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

118G

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

119V

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

121T

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

123F

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

138Q

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

141L

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

258P

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

259K

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

260E

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

261G

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

262L

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

266N

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

357Y

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

360R

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

390N

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)

402H

active sites
117Y, 118G, 119V, 121T, 123F, 138Q, 141L, 258P, 259K, 260E, 261G, 262L, 266N, 357Y, 360R, 390N, 402H
CDD
cd00332 (PAL-HAL)
tetramer interface...

122G

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

123F

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

140E

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

143R

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

144F

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

145L

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

146N

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

147A

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

148G

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

149V

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

155G

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

176Q

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

204R

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

205G

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

218Y

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

221G

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

310L

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

311T

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

314L

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

315K

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

317H

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

320Q

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

354Q

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

356R

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

357Y

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

358A

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

360R

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

361T

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

364Q

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

365W

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

371E

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

372V

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

375Q

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

378H

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

379S

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

382R

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

383E

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

386S

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

387V

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

392L

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

393I

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

394D

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

399M

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

401V

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

402H

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

403G

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

404G

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

405N

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

406F

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

407Q

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

409T

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

410P

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

413V

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

417N

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

424A

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

427K

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

431A

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

435E

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

438N

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

441Y

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

456S

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

457L

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

459Y

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

460G

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

462K

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

463G

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

464A

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

465E

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

467A

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

469A

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

470S

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

471Y

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

472C

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

473S

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

474E

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

476L

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

477Y

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

478L

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

479A

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

490E

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

491Q

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

492H

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

493N

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

494Q

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

495D

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

496V

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

499L

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

505R

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

506K

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

509E

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

512E

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

513V

tetramer interface
122G, 123F, 140E, 143R, 144F, 145L, 146N, 147A, 148G, 149V, 155G, 176Q, 204R, 205G, 218Y, 221G, 310L, 311T, 314L, 315K, 317H, 320Q, 354Q, 356R, 357Y, 358A, 360R, 361T, 364Q, 365W, 371E, 372V, 375Q, 378H, 379S, 382R, 383E, 386S, 387V, 392L, 393I, 394D, 399M, 401V, 402H, 403G, 404G, 405N, 406F, 407Q, 409T, 410P, 413V, 417N, 424A, 427K, 431A, 435E, 438N, 441Y, 456S, 457L, 459Y, 460G, 462K, 463G, 464A, 465E, 467A, 469A, 470S, 471Y, 472C, 473S, 474E, 476L, 477Y, 478L, 479A, 490E, 491Q, 492H, 493N, 494Q, 495D, 496V, 499L, 505R, 506K, 509E, 512E, 513V
CDD
cd00332 (PAL-HAL)

GO term prediction

Biological Process

GO:0006559 L-phenylalanine catabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0016841 ammonia-lyase activity

Cellular Component

GO:0005737 cytoplasm

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Entry type

Status

Per-residue features