Mp1g21090.1

Protein

Length

1,410 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
525 - 604
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (IPR036097)
Homologous superfamily
592 - 799
Histidine kinase/HSP90-like ATPase superfamily (IPR036890)
1,252 - 1,403
CheY-like superfamily (IPR011006)

1 200 400 600 800 1000 1200 1410

Domains and repeats

Domain
537 - 603
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (IPR003661)
650 - 800
Histidine kinase/HSP90-like ATPase (IPR003594)
1,254 - 1,396
Signal transduction response regulator, receiver domain (IPR001789)
Domain
544 - 798
Histidine kinase domain (IPR005467)
Domain
723 - 737
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
741 - 751
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
758 - 776
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)

1 200 400 600 800 1000 1200 1410

Detailed signature matches

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
1. SSF47384 (Homodimer...)
  
  525 - 604
  
  SUPERFAMILY
  SSF47384 (Homodimeric domain of signal transducing histidine kinase)
IPR036890

Histidine kinase/HSP90-like ATPase superfamily
1. G3DSA:3.30.56...
  
  605 - 799
  
  GENE3D
  G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
2. SSF55874 (ATPase do...)
  
  722 - 794
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
  
  592 - 684
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
IPR011006

CheY-like superfamily
1. SSF52172 (CheY-like)
  
  1,252 - 1,403
  
  SUPERFAMILY
  SSF52172 (CheY-like)
IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
1. cd00082 (HisKA)
  
  538 - 599
  
  CDD
  cd00082 (HisKA)
2. SM00388 (HisKA_10)
  
  537 - 603
  
  SMART
  SM00388 (HisKA_10)
3. PF00512 (HisKA)
  
  538 - 603
  
  Pfam
  PF00512 (HisKA)
IPR005467

Histidine kinase domain
1. PS50109 (HIS_KIN)
  
  544 - 798
  
  PROSITE profiles
  PS50109 (HIS_KIN)
IPR003594

Histidine kinase/HSP90-like ATPase
1. PF02518 (HATPase_c)
  
  650 - 793
  
  Pfam
  PF02518 (HATPase_c)
2. SM00387 (HKATPase_4)
  
  650 - 800
  
  SMART
  SM00387 (HKATPase_4)
IPR004358

Signal transduction histidine kinase-related protein, C-terminal
1. PR00344 (BCTRLSENSOR)
  
  741 - 751
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  723 - 737
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  758 - 776
  
  PRINTS
  PR00344 (BCTRLSENSOR)
IPR001789

Signal transduction response regulator, receiver domain
1. PS50110 (RESPONSE_R...)
  
  1,255 - 1,396
  
  PROSITE profiles
  PS50110 (RESPONSE_REGULATORY)
2. PF00072 (Response_reg)
  
  1,256 - 1,392
  
  Pfam
  PF00072 (Response_reg)
3. SM00448 (REC_2)
  
  1,254 - 1,392
  
  SMART
  SM00448 (REC_2)

no IPR

Unintegrated signatures

G3DSA:1.10.28...

525 - 604

GENE3D
G3DSA:1.10.287.130 (G3DSA:1.10.287.130)
G3DSA:3.40.50...

1,234 - 1,403

GENE3D
G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)
PTHR43711 (TWO-COMP...)

97 - 877

PANTHER
PTHR43711 (TWO-COMPONENT HISTIDINE KINASE)

1,246 - 1,397

PANTHER
PTHR43711 (TWO-COMPONENT HISTIDINE KINASE)
PTHR43711:SF18 (SUB...)

97 - 877

PANTHER
PTHR43711:SF18 (SUBFAMILY NOT NAMED)

1,246 - 1,397

PANTHER
PTHR43711:SF18 (SUBFAMILY NOT NAMED)
cd17546 (REC_hyHK_C...)

1,256 - 1,392

CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

Other features

mobidb-lite (disord...)

1,063 - 1,092

MobiDB Lite
mobidb-lite (disorder_prediction)

1,162 - 1,183

MobiDB Lite
mobidb-lite (disorder_prediction)

1,200 - 1,219

MobiDB Lite
mobidb-lite (disorder_prediction)

1,120 - 1,149

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Polyam...)

1,129 - 1,149

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte
mobidb-lite (Polar)

1,068 - 1,092

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

1,166 - 1,183

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

Residue annotation

dimer interface cd...

541F

dimer interface
541F, 545M, 549L, 552P, 556V, 559L, 576M, 580I, 583C, 587L, 590L, 594I
CDD
cd00082 (HisKA)

545M

dimer interface
541F, 545M, 549L, 552P, 556V, 559L, 576M, 580I, 583C, 587L, 590L, 594I
CDD
cd00082 (HisKA)

549L

dimer interface
541F, 545M, 549L, 552P, 556V, 559L, 576M, 580I, 583C, 587L, 590L, 594I
CDD
cd00082 (HisKA)

552P

dimer interface
541F, 545M, 549L, 552P, 556V, 559L, 576M, 580I, 583C, 587L, 590L, 594I
CDD
cd00082 (HisKA)

556V

dimer interface
541F, 545M, 549L, 552P, 556V, 559L, 576M, 580I, 583C, 587L, 590L, 594I
CDD
cd00082 (HisKA)

559L

dimer interface
541F, 545M, 549L, 552P, 556V, 559L, 576M, 580I, 583C, 587L, 590L, 594I
CDD
cd00082 (HisKA)

576M

dimer interface
541F, 545M, 549L, 552P, 556V, 559L, 576M, 580I, 583C, 587L, 590L, 594I
CDD
cd00082 (HisKA)

580I

dimer interface
541F, 545M, 549L, 552P, 556V, 559L, 576M, 580I, 583C, 587L, 590L, 594I
CDD
cd00082 (HisKA)

583C

dimer interface
541F, 545M, 549L, 552P, 556V, 559L, 576M, 580I, 583C, 587L, 590L, 594I
CDD
cd00082 (HisKA)

587L

dimer interface
541F, 545M, 549L, 552P, 556V, 559L, 576M, 580I, 583C, 587L, 590L, 594I
CDD
cd00082 (HisKA)

590L

dimer interface
541F, 545M, 549L, 552P, 556V, 559L, 576M, 580I, 583C, 587L, 590L, 594I
CDD
cd00082 (HisKA)

594I

dimer interface
541F, 545M, 549L, 552P, 556V, 559L, 576M, 580I, 583C, 587L, 590L, 594I
CDD
cd00082 (HisKA)
phosphorylation si...

547H

phosphorylation site
547H
CDD
cd00082 (HisKA)
Hpt domain binding...

1,262T

Hpt domain binding site
1,262T, 1,264V, 1,265L, 1,267R, 1,268V, 1,271M, 1,272M, 1,275K, 1,360A, 1,382P, 1,384D, 1,385P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,264V

Hpt domain binding site
1,262T, 1,264V, 1,265L, 1,267R, 1,268V, 1,271M, 1,272M, 1,275K, 1,360A, 1,382P, 1,384D, 1,385P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,265L

Hpt domain binding site
1,262T, 1,264V, 1,265L, 1,267R, 1,268V, 1,271M, 1,272M, 1,275K, 1,360A, 1,382P, 1,384D, 1,385P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,267R

Hpt domain binding site
1,262T, 1,264V, 1,265L, 1,267R, 1,268V, 1,271M, 1,272M, 1,275K, 1,360A, 1,382P, 1,384D, 1,385P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,268V

Hpt domain binding site
1,262T, 1,264V, 1,265L, 1,267R, 1,268V, 1,271M, 1,272M, 1,275K, 1,360A, 1,382P, 1,384D, 1,385P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,271M

Hpt domain binding site
1,262T, 1,264V, 1,265L, 1,267R, 1,268V, 1,271M, 1,272M, 1,275K, 1,360A, 1,382P, 1,384D, 1,385P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,272M

Hpt domain binding site
1,262T, 1,264V, 1,265L, 1,267R, 1,268V, 1,271M, 1,272M, 1,275K, 1,360A, 1,382P, 1,384D, 1,385P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,275K

Hpt domain binding site
1,262T, 1,264V, 1,265L, 1,267R, 1,268V, 1,271M, 1,272M, 1,275K, 1,360A, 1,382P, 1,384D, 1,385P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,360A

Hpt domain binding site
1,262T, 1,264V, 1,265L, 1,267R, 1,268V, 1,271M, 1,272M, 1,275K, 1,360A, 1,382P, 1,384D, 1,385P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,382P

Hpt domain binding site
1,262T, 1,264V, 1,265L, 1,267R, 1,268V, 1,271M, 1,272M, 1,275K, 1,360A, 1,382P, 1,384D, 1,385P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,384D

Hpt domain binding site
1,262T, 1,264V, 1,265L, 1,267R, 1,268V, 1,271M, 1,272M, 1,275K, 1,360A, 1,382P, 1,384D, 1,385P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,385P

Hpt domain binding site
1,262T, 1,264V, 1,265L, 1,267R, 1,268V, 1,271M, 1,272M, 1,275K, 1,360A, 1,382P, 1,384D, 1,385P
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

GO term prediction

Biological Process

GO:0000160 phosphorelay signal transduction system
GO:0007165 signal transduction
GO:0016310 phosphorylation

Molecular Function

GO:0000155 phosphorelay sensor kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component