Mp1g26610.1

Protein

Length

703 amino acids

Protein family membership

Heat shock protein Hsp90 family (IPR001404)

Homologous superfamilies

Homologous superfamily
10 - 219
Histidine kinase/HSP90-like ATPase superfamily (IPR036890)
522 - 671
HSP90, C-terminal domain (IPR037196)
Homologous superfamily
267 - 522
Ribosomal protein S5 domain 2-type fold (IPR020568)

1 100 200 300 400 500 600 703

Domains and repeats

Domain
11 - 31
Heat shock protein Hsp90, N-terminal (IPR020575)
32 - 193
Histidine kinase/HSP90-like ATPase (IPR003594)
Heat shock protein Hsp90, N-terminal (IPR020575)
194 - 212
Heat shock protein Hsp90, N-terminal (IPR020575)

1 100 200 300 400 500 600 703

Detailed signature matches

IPR036890

Histidine kinase/HSP90-like ATPase superfamily
1. G3DSA:3.30.56...
  
  11 - 216
  
  GENE3D
  G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
2. SSF55874 (ATPase do...)
  
  10 - 219
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
IPR020568

Ribosomal protein S5 domain 2-type fold
1. SSF54211 (Ribosomal...)
  
  267 - 522
  
  SUPERFAMILY
  SSF54211 (Ribosomal protein S5 domain 2-like)
IPR037196

HSP90, C-terminal domain
1. SSF110942 (HSP90 C-...)
  
  546 - 667
  
  SUPERFAMILY
  SSF110942 (HSP90 C-terminal domain)
2. G3DSA:1.20.12...
  
  522 - 671
  
  GENE3D
  G3DSA:1.20.120.790 (G3DSA:1.20.120.790)
IPR001404

Heat shock protein Hsp90 family
1. PIRSF002583 (HSP90_...)
  
  1 - 703
  
  PIRSF
  PIRSF002583 (HSP90_HTPG)
2. MF_00505 (HSP90)
  
  8 - 668
  
  HAMAP
  MF_00505 (HSP90)
3. PTHR11528 (HEAT SHO...)
  
  9 - 701
  
  PANTHER
  PTHR11528 (HEAT SHOCK PROTEIN 90 FAMILY MEMBER)
4. PF00183 (HSP90)
  
  190 - 686
  
  Pfam
  PF00183 (HSP90)
IPR003594

Histidine kinase/HSP90-like ATPase
1. PF02518 (HATPase_c)
  
  33 - 187
  
  Pfam
  PF02518 (HATPase_c)
2. SM00387 (HKATPase_4)
  
  33 - 188
  
  SMART
  SM00387 (HKATPase_4)
IPR020575

Heat shock protein Hsp90, N-terminal
1. PR00775 (HEATSHOCK90)
  
  81 - 98
  
  PRINTS
  PR00775 (HEATSHOCK90)
  
  11 - 31
  
  PRINTS
  PR00775 (HEATSHOCK90)
  
  32 - 54
  
  PRINTS
  PR00775 (HEATSHOCK90)
  
  99 - 116
  
  PRINTS
  PR00775 (HEATSHOCK90)
  
  194 - 212
  
  PRINTS
  PR00775 (HEATSHOCK90)
  
  124 - 146
  
  PRINTS
  PR00775 (HEATSHOCK90)
  
  176 - 193
  
  PRINTS
  PR00775 (HEATSHOCK90)
IPR019805

Heat shock protein Hsp90, conserved site
1. PS00298 (HSP90)
  
  31 - 40
  
  PROSITE patterns
  PS00298 (HSP90)

no IPR

Unintegrated signatures

G3DSA:3.30.23...

266 - 434

GENE3D
G3DSA:3.30.230.80 (G3DSA:3.30.230.80)
G3DSA:3.30.70...

217 - 256

GENE3D
G3DSA:3.30.70.2140 (G3DSA:3.30.70.2140)
G3DSA:3.40.50...

435 - 521

GENE3D
G3DSA:3.40.50.11260 (G3DSA:3.40.50.11260)
PTHR11528:SF115 (HE...)

9 - 701

PANTHER
PTHR11528:SF115 (HEAT SHOCK PROTEIN 81-2)
cd16927 (HATPase_Hs...)

20 - 208

CDD
cd16927 (HATPase_Hsp90-like)

Other features

Coil

526 - 546

COILS
Coil (Coil)

225 - 259

COILS
Coil (Coil)
mobidb-lite (disord...)

223 - 246

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Negati...)

223 - 242

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Negative Polyelectrolyte

Residue annotation

homodimer interfac...

21Q

homodimer interface
21Q, 22L, 25L, 29T, 104A, 127F
CDD
cd16927 (HATPase_Hsp90-like)

22L

homodimer interface
21Q, 22L, 25L, 29T, 104A, 127F
CDD
cd16927 (HATPase_Hsp90-like)

25L

homodimer interface
21Q, 22L, 25L, 29T, 104A, 127F
CDD
cd16927 (HATPase_Hsp90-like)

29T

homodimer interface
21Q, 22L, 25L, 29T, 104A, 127F
CDD
cd16927 (HATPase_Hsp90-like)

104A

homodimer interface
21Q, 22L, 25L, 29T, 104A, 127F
CDD
cd16927 (HATPase_Hsp90-like)

127F

homodimer interface
21Q, 22L, 25L, 29T, 104A, 127F
CDD
cd16927 (HATPase_Hsp90-like)
ATP binding site c...

40E

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

44N

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

45A

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

47D

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

48A

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

51K

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

84I

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

86D

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

88G

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

90G

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

91M

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

99N

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

100L

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

102T

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

103I

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

104A

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

105R

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

106S

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

107G

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

108T

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

125G

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

126Q

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

127F

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

128G

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

129V

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

130G

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

131F

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

143V

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

145S

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

177G

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

178T

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)

180I

ATP binding site
40E, 44N, 45A, 47D, 48A, 51K, 84I, 86D, 88G, 90G, 91M, 99N, 100L, 102T, 103I, 104A, 105R, 106S, 107G, 108T, 125G, 126Q, 127F, 128G, 129V, 130G, 131F, 143V, 145S, 177G, 178T, 180I
CDD
cd16927 (HATPase_Hsp90-like)
ATP-lid cd16927

100L

ATP-lid
100L, 131F
CDD
cd16927 (HATPase_Hsp90-like)

131F

ATP-lid
100L, 131F
CDD
cd16927 (HATPase_Hsp90-like)

GO term prediction

Biological Process

GO:0006457 protein folding

Molecular Function

GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0051082 unfolded protein binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features