Mp2g11400.1

Protein

Length

579 amino acids

Protein family membership

Isocitrate lyase (IPR006254)

Homologous superfamilies

Homologous superfamily
36 - 551
Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily (IPR015813)
Homologous superfamily
42 - 546
Pyruvate kinase-like domain superfamily (IPR040442)

1 100 200 300 400 500 579

Domains and repeats

Domain
90 - 505
ICL/PEPM domain (IPR039556)

1 100 200 300 400 500 579

Detailed signature matches

IPR015813

Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily
1. SSF51621 (Phosphoen...)
  
  36 - 551
  
  SUPERFAMILY
  SSF51621 (Phosphoenolpyruvate/pyruvate domain)
IPR040442

Pyruvate kinase-like domain superfamily
1. G3DSA:3.20.20.60
  
  42 - 285
  
  GENE3D
  G3DSA:3.20.20.60 (G3DSA:3.20.20.60)
  
  394 - 546
  
  GENE3D
  G3DSA:3.20.20.60 (G3DSA:3.20.20.60)
IPR006254

Isocitrate lyase
1. PIRSF001362 (ICL)
  
  37 - 310
  
  PIRSF
  PIRSF001362 (ICL)
  
  383 - 570
  
  PIRSF
  PIRSF001362 (ICL)
2. PF00463 (ICL)
  
  46 - 567
  
  Pfam
  PF00463 (ICL)
3. PTHR21631 (ISOCITRA...)
  
  37 - 570
  
  PANTHER
  PTHR21631 (ISOCITRATE LYASE/MALATE SYNTHASE)
4. TIGR01346
  
  46 - 567
  
  TIGRFAMs
  TIGR01346 (TIGR01346)
IPR039556

ICL/PEPM domain
1. cd00377 (ICL_PEPM)
  
  90 - 505
  
  CDD
  cd00377 (ICL_PEPM)
IPR018523

Isocitrate lyase/phosphorylmutase, conserved site
1. PS00161 (ISOCITRATE...)
  
  235 - 240
  
  PROSITE patterns
  PS00161 (ISOCITRATE_LYASE)

no IPR

Unintegrated signatures

G3DSA:1.10.10...

286 - 393

GENE3D
G3DSA:1.10.10.850 (G3DSA:1.10.10.850)

Other features

Coil

578 - 579

COILS
Coil (Coil)

Residue annotation

tetramer interface...

92N

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

103A

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

105R

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

106T

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

107F

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

108G

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

110L

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

111D

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

112P

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

113V

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

114Q

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

116A

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

117Q

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

120K

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

122L

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

123D

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

130W

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

134S

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

135T

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

143G

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

144P

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

147A

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

148D

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

149Y

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

150P

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

152D

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

153T

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

156N

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

157K

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

159Q

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

160H

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

163L

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

164A

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

205G

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

211I

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

212K

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

216M

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

219E

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

249T

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

250E

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

253N

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

256I

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

257A

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

260L

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

494A

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

495N

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

496A

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

498M

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

499V

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

500D

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

502F

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

503A

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)

504K

tetramer interface
92N, 103A, 105R, 106T, 107F, 108G, 110L, 111D, 112P, 113V, 114Q, 116A, 117Q, 120K, 122L, 123D, 130W, 134S, 135T, 143G, 144P, 147A, 148D, 149Y, 150P, 152D, 153T, 156N, 157K, 159Q, 160H, 163L, 164A, 205G, 211I, 212K, 216M, 219E, 249T, 250E, 253N, 256I, 257A, 260L, 494A, 495N, 496A, 498M, 499V, 500D, 502F, 503A, 504K
CDD
cd00377 (ICL_PEPM)
active site cd00377

126Y

active site
126Y, 128S, 129G, 130W, 145D, 199D, 201D, 228E, 274R, 425E, 453N, 455S, 488T
CDD
cd00377 (ICL_PEPM)

128S

active site
126Y, 128S, 129G, 130W, 145D, 199D, 201D, 228E, 274R, 425E, 453N, 455S, 488T
CDD
cd00377 (ICL_PEPM)

129G

active site
126Y, 128S, 129G, 130W, 145D, 199D, 201D, 228E, 274R, 425E, 453N, 455S, 488T
CDD
cd00377 (ICL_PEPM)

130W

active site
126Y, 128S, 129G, 130W, 145D, 199D, 201D, 228E, 274R, 425E, 453N, 455S, 488T
CDD
cd00377 (ICL_PEPM)

145D

active site
126Y, 128S, 129G, 130W, 145D, 199D, 201D, 228E, 274R, 425E, 453N, 455S, 488T
CDD
cd00377 (ICL_PEPM)

199D

active site
126Y, 128S, 129G, 130W, 145D, 199D, 201D, 228E, 274R, 425E, 453N, 455S, 488T
CDD
cd00377 (ICL_PEPM)

201D

active site
126Y, 128S, 129G, 130W, 145D, 199D, 201D, 228E, 274R, 425E, 453N, 455S, 488T
CDD
cd00377 (ICL_PEPM)

228E

active site
126Y, 128S, 129G, 130W, 145D, 199D, 201D, 228E, 274R, 425E, 453N, 455S, 488T
CDD
cd00377 (ICL_PEPM)

274R

active site
126Y, 128S, 129G, 130W, 145D, 199D, 201D, 228E, 274R, 425E, 453N, 455S, 488T
CDD
cd00377 (ICL_PEPM)

425E

active site
126Y, 128S, 129G, 130W, 145D, 199D, 201D, 228E, 274R, 425E, 453N, 455S, 488T
CDD
cd00377 (ICL_PEPM)

453N

active site
126Y, 128S, 129G, 130W, 145D, 199D, 201D, 228E, 274R, 425E, 453N, 455S, 488T
CDD
cd00377 (ICL_PEPM)

455S

active site
126Y, 128S, 129G, 130W, 145D, 199D, 201D, 228E, 274R, 425E, 453N, 455S, 488T
CDD
cd00377 (ICL_PEPM)

488T

active site
126Y, 128S, 129G, 130W, 145D, 199D, 201D, 228E, 274R, 425E, 453N, 455S, 488T
CDD
cd00377 (ICL_PEPM)
Mg2+/Mn2+ binding ...

145D

Mg2+/Mn2+ binding site
145D, 199D, 201D, 228E
CDD
cd00377 (ICL_PEPM)

199D

Mg2+/Mn2+ binding site
145D, 199D, 201D, 228E
CDD
cd00377 (ICL_PEPM)

201D

Mg2+/Mn2+ binding site
145D, 199D, 201D, 228E
CDD
cd00377 (ICL_PEPM)

228E

Mg2+/Mn2+ binding site
145D, 199D, 201D, 228E
CDD
cd00377 (ICL_PEPM)

GO term prediction

Biological Process

GO:0019752 carboxylic acid metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004451 isocitrate lyase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features