Mp2g13820.1

Protein

Length

304 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
1 - 296
Metallo-dependent phosphatase-like (IPR029052)

1 50 100 150 200 250 304

Domains and repeats

Domain
17 - 287
Calcineurin-like phosphoesterase domain, ApaH type (IPR004843)
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186)

1 50 100 150 200 250 304

Detailed signature matches

IPR029052

Metallo-dependent phosphatase-like
1. G3DSA:3.60.21.10
  
  1 - 296
  
  GENE3D
  G3DSA:3.60.21.10 (G3DSA:3.60.21.10)
IPR004843

Calcineurin-like phosphoesterase domain, ApaH type
1. PF00149 (Metallophos)
  
  45 - 236
  
  Pfam
  PF00149 (Metallophos)
IPR006186

Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
1. PS00125 (SER_THR_PH...)
  
  108 - 113
  
  PROSITE patterns
  PS00125 (SER_THR_PHOSPHATASE)
2. SM00156 (pp2a_7)
  
  17 - 287
  
  SMART
  SM00156 (pp2a_7)
3. PR00114 (STPHPHTASE)
  
  45 - 72
  
  PRINTS
  PR00114 (STPHPHTASE)
  
  171 - 198
  
  PRINTS
  PR00114 (STPHPHTASE)
  
  74 - 101
  
  PRINTS
  PR00114 (STPHPHTASE)
  
  107 - 131
  
  PRINTS
  PR00114 (STPHPHTASE)
  
  227 - 247
  
  PRINTS
  PR00114 (STPHPHTASE)
  
  249 - 265
  
  PRINTS
  PR00114 (STPHPHTASE)
  
  142 - 168
  
  PRINTS
  PR00114 (STPHPHTASE)

no IPR

Unintegrated signatures

PTHR45619 (SERINE/T...)

1 - 304

PANTHER
PTHR45619 (SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED)
PTHR45619:SF29 (SER...)

1 - 304

PANTHER
PTHR45619:SF29 (SERINE/THREONINE-PROTEIN PHOSPHATASE PP-X ISOZYME 1)
SSF56300 (Metallo-d...)

2 - 290

SUPERFAMILY
SSF56300 (Metallo-dependent phosphatases)
cd07415 (MPP_PP2A_P...)

3 - 287

CDD
cd07415 (MPP_PP2A_PP4_PP6)

Residue annotation

heterotrimer inter...

45P

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

61E

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

64K

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

65V

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

67G

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

68D

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

70P

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

72T

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

73N

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

85F

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

100R

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

101Y

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

102P

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

103D

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

104R

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

115R

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

116Q

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

119Q

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

120V

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

124Y

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

125D

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

128L

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

129R

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

137W

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

262R

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

271E

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

281T

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)

287P

heterotrimer interface
45P, 61E, 64K, 65V, 67G, 68D, 70P, 72T, 73N, 85F, 100R, 101Y, 102P, 103D, 104R, 115R, 116Q, 119Q, 120V, 124Y, 125D, 128L, 129R, 137W, 262R, 271E, 281T, 287P
CDD
cd07415 (MPP_PP2A_PP4_PP6)
metal binding site...

51D

metal binding site
51D, 53H, 79D, 111N, 161H, 235H
CDD
cd07415 (MPP_PP2A_PP4_PP6)

53H

metal binding site
51D, 53H, 79D, 111N, 161H, 235H
CDD
cd07415 (MPP_PP2A_PP4_PP6)

79D

metal binding site
51D, 53H, 79D, 111N, 161H, 235H
CDD
cd07415 (MPP_PP2A_PP4_PP6)

111N

metal binding site
51D, 53H, 79D, 111N, 161H, 235H
CDD
cd07415 (MPP_PP2A_PP4_PP6)

161H

metal binding site
51D, 53H, 79D, 111N, 161H, 235H
CDD
cd07415 (MPP_PP2A_PP4_PP6)

235H

metal binding site
51D, 53H, 79D, 111N, 161H, 235H
CDD
cd07415 (MPP_PP2A_PP4_PP6)
active site cd07415

51D

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

53H

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

79D

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

83R

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

111N

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

112H

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

116Q

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

117I

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

121Y

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

161H

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

183V

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

184P

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

185H

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

194W

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

207P

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

208R

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

209G

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

235H

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

237L

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

261Y

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

262R

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

263C

active site
51D, 53H, 79D, 83R, 111N, 112H, 116Q, 117I, 121Y, 161H, 183V, 184P, 185H, 194W, 207P, 208R, 209G, 235H, 237L, 261Y, 262R, 263C
CDD
cd07415 (MPP_PP2A_PP4_PP6)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016787 hydrolase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

Mp2g13820.1

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component