Mp2g19480.1

Protein

Length

428 amino acids

Protein family membership

Polyketide synthase, type III (IPR011141)

Homologous superfamilies

Homologous superfamily
11 - 273
Thiolase-like (IPR016039)
273 - 427
Thiolase-like (IPR016039)

1 50 100 150 200 250 300 350 400 428

Domains and repeats

Domain
48 - 266
Chalcone/stilbene synthase, N-terminal (IPR001099)
276 - 426
Chalcone/stilbene synthase, C-terminal (IPR012328)

1 50 100 150 200 250 300 350 400 428

Detailed signature matches

IPR016039

Thiolase-like
1. SSF53901 (Thiolase-...)
  
  53 - 271
  
  SUPERFAMILY
  SSF53901 (Thiolase-like)
  
  273 - 426
  
  SUPERFAMILY
  SSF53901 (Thiolase-like)
2. G3DSA:3.40.47.10
  
  11 - 273
  
  GENE3D
  G3DSA:3.40.47.10 (G3DSA:3.40.47.10)
  
  274 - 427
  
  GENE3D
  G3DSA:3.40.47.10 (G3DSA:3.40.47.10)
IPR011141

Polyketide synthase, type III
1. PTHR11877 (HYDROXYM...)
  
  47 - 424
  
  PANTHER
  PTHR11877 (HYDROXYMETHYLGLUTARYL-COA SYNTHASE)
2. PIRSF000451 (PKS_III)
  
  40 - 426
  
  PIRSF
  PIRSF000451 (PKS_III)
IPR001099

Chalcone/stilbene synthase, N-terminal
1. PF00195 (Chal_sti_s...)
  
  48 - 266
  
  Pfam
  PF00195 (Chal_sti_synt_N)
IPR012328

Chalcone/stilbene synthase, C-terminal
1. PF02797 (Chal_sti_s...)
  
  276 - 426
  
  Pfam
  PF02797 (Chal_sti_synt_C)

no IPR

Unintegrated signatures

PTHR11877:SF14 (CHA...)

47 - 424

PANTHER
PTHR11877:SF14 (CHALCONE SYNTHASE)
cd00831 (CHS_like)

54 - 422

CDD
cd00831 (CHS_like)

Residue annotation

malonyl-CoA bindin...

93R

malonyl-CoA binding site
93R, 96R, 97I, 253C, 303Y, 344G, 345R, 346A
CDD
cd00831 (CHS_like)

96R

malonyl-CoA binding site
93R, 96R, 97I, 253C, 303Y, 344G, 345R, 346A
CDD
cd00831 (CHS_like)

97I

malonyl-CoA binding site
93R, 96R, 97I, 253C, 303Y, 344G, 345R, 346A
CDD
cd00831 (CHS_like)

253C

malonyl-CoA binding site
93R, 96R, 97I, 253C, 303Y, 344G, 345R, 346A
CDD
cd00831 (CHS_like)

303Y

malonyl-CoA binding site
93R, 96R, 97I, 253C, 303Y, 344G, 345R, 346A
CDD
cd00831 (CHS_like)

344G

malonyl-CoA binding site
93R, 96R, 97I, 253C, 303Y, 344G, 345R, 346A
CDD
cd00831 (CHS_like)

345R

malonyl-CoA binding site
93R, 96R, 97I, 253C, 303Y, 344G, 345R, 346A
CDD
cd00831 (CHS_like)

346A

malonyl-CoA binding site
93R, 96R, 97I, 253C, 303Y, 344G, 345R, 346A
CDD
cd00831 (CHS_like)
dimer interface cd...

129L

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

130D

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

133Q

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

174N

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

175M

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

180L

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

184R

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

190P

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

191S

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

192V

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

193N

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

194R

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

195V

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

196M

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

200Q

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

201G

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

210R

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

211V

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

214D

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

217E

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

218N

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

219N

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

280C

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

282Q

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

283T

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

284I

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

294G

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

295R

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

296L

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

297S

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)

416T

dimer interface
129L, 130D, 133Q, 174N, 175M, 180L, 184R, 190P, 191S, 192V, 193N, 194R, 195V, 196M, 200Q, 201G, 210R, 211V, 214D, 217E, 218N, 219N, 280C, 282Q, 283T, 284I, 294G, 295R, 296L, 297S, 416T
CDD
cd00831 (CHS_like)
active site cd00831

202S

active site
202S, 341H, 374N
CDD
cd00831 (CHS_like)

341H

active site
202S, 341H, 374N
CDD
cd00831 (CHS_like)

374N

active site
202S, 341H, 374N
CDD
cd00831 (CHS_like)
product binding si...

230E

product binding site
230E, 231I, 232T, 254S, 292I, 293E, 294G, 302I, 303Y, 376S, 413P
CDD
cd00831 (CHS_like)

231I

product binding site
230E, 231I, 232T, 254S, 292I, 293E, 294G, 302I, 303Y, 376S, 413P
CDD
cd00831 (CHS_like)

232T

product binding site
230E, 231I, 232T, 254S, 292I, 293E, 294G, 302I, 303Y, 376S, 413P
CDD
cd00831 (CHS_like)

254S

product binding site
230E, 231I, 232T, 254S, 292I, 293E, 294G, 302I, 303Y, 376S, 413P
CDD
cd00831 (CHS_like)

292I

product binding site
230E, 231I, 232T, 254S, 292I, 293E, 294G, 302I, 303Y, 376S, 413P
CDD
cd00831 (CHS_like)

293E

product binding site
230E, 231I, 232T, 254S, 292I, 293E, 294G, 302I, 303Y, 376S, 413P
CDD
cd00831 (CHS_like)

294G

product binding site
230E, 231I, 232T, 254S, 292I, 293E, 294G, 302I, 303Y, 376S, 413P
CDD
cd00831 (CHS_like)

302I

product binding site
230E, 231I, 232T, 254S, 292I, 293E, 294G, 302I, 303Y, 376S, 413P
CDD
cd00831 (CHS_like)

303Y

product binding site
230E, 231I, 232T, 254S, 292I, 293E, 294G, 302I, 303Y, 376S, 413P
CDD
cd00831 (CHS_like)

376S

product binding site
230E, 231I, 232T, 254S, 292I, 293E, 294G, 302I, 303Y, 376S, 413P
CDD
cd00831 (CHS_like)

413P

product binding site
230E, 231I, 232T, 254S, 292I, 293E, 294G, 302I, 303Y, 376S, 413P
CDD
cd00831 (CHS_like)

GO term prediction

Biological Process

GO:0009058 biosynthetic process

Molecular Function

GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

None predicted.

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Entry type

Status

Per-residue features