Mp2g20220.1

Protein

Length

529 amino acids

Protein family membership

Very-long-chain 3-ketoacyl-CoA synthase (IPR012392)

Homologous superfamilies

Homologous superfamily
112 - 505
Thiolase-like (IPR016039)

1 50 100 150 200 250 300 350 400 450 500 529

Domains and repeats

Domain
116 - 404
FAE1/Type III polyketide synthase-like protein (IPR013601)
422 - 502
3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal (IPR013747)

1 50 100 150 200 250 300 350 400 450 500 529

Detailed signature matches

IPR016039

Thiolase-like
1. SSF53901 (Thiolase-...)
  
  414 - 505
  
  SUPERFAMILY
  SSF53901 (Thiolase-like)
  
  309 - 386
  
  SUPERFAMILY
  SSF53901 (Thiolase-like)
  
  112 - 328
  
  SUPERFAMILY
  SSF53901 (Thiolase-like)
2. G3DSA:3.40.47.10
  
  151 - 503
  
  GENE3D
  G3DSA:3.40.47.10 (G3DSA:3.40.47.10)
IPR012392

Very-long-chain 3-ketoacyl-CoA synthase
1. PTHR31561 (3-KETOAC...)
  
  26 - 528
  
  PANTHER
  PTHR31561 (3-KETOACYL-COA SYNTHASE)
2. PIRSF036417 (Very_l...)
  
  42 - 529
  
  PIRSF
  PIRSF036417 (Very_long_ch_3-ktacl-CoA_syn)
IPR013601

FAE1/Type III polyketide synthase-like protein
1. PF08392 (FAE1_CUT1_...)
  
  116 - 404
  
  Pfam
  PF08392 (FAE1_CUT1_RppA)
IPR013747

3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal
1. PF08541 (ACP_syn_III_C)
  
  422 - 502
  
  Pfam
  PF08541 (ACP_syn_III_C)

no IPR

Unintegrated signatures

PTHR31561:SF103 (3-...)

26 - 528

PANTHER
PTHR31561:SF103 (3-KETOACYL-COA SYNTHASE 11)
cd00831 (CHS_like)

106 - 501

CDD
cd00831 (CHS_like)

Residue annotation

malonyl-CoA bindin...

144F

malonyl-CoA binding site
144F, 147D, 148M, 309F, 430G, 431R, 432A
CDD
cd00831 (CHS_like)

147D

malonyl-CoA binding site
144F, 147D, 148M, 309F, 430G, 431R, 432A
CDD
cd00831 (CHS_like)

148M

malonyl-CoA binding site
144F, 147D, 148M, 309F, 430G, 431R, 432A
CDD
cd00831 (CHS_like)

309F

malonyl-CoA binding site
144F, 147D, 148M, 309F, 430G, 431R, 432A
CDD
cd00831 (CHS_like)

430G

malonyl-CoA binding site
144F, 147D, 148M, 309F, 430G, 431R, 432A
CDD
cd00831 (CHS_like)

431R

malonyl-CoA binding site
144F, 147D, 148M, 309F, 430G, 431R, 432A
CDD
cd00831 (CHS_like)

432A

malonyl-CoA binding site
144F, 147D, 148M, 309F, 430G, 431R, 432A
CDD
cd00831 (CHS_like)
dimer interface cd...

183L

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

184A

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

187P

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

232P

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

233T

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

238A

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

242N

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

248G

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

249N

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

250I

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

251K

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

252S

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

253L

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

254N

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

258M

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

259G

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

268D

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

269L

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

272D

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

275Q

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

276V

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

277H

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

346C

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

348R

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

349C

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

350V

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

362V

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

363S

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

364L

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

365S

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)

495K

dimer interface
183L, 184A, 187P, 232P, 233T, 238A, 242N, 248G, 249N, 250I, 251K, 252S, 253L, 254N, 258M, 259G, 268D, 269L, 272D, 275Q, 276V, 277H, 346C, 348R, 349C, 350V, 362V, 363S, 364L, 365S, 495K
CDD
cd00831 (CHS_like)
active site cd00831

260C

active site
260C, 427H, 460N
CDD
cd00831 (CHS_like)

427H

active site
260C, 427H, 460N
CDD
cd00831 (CHS_like)

460N

active site
260C, 427H, 460N
CDD
cd00831 (CHS_like)
product binding si...

288E

product binding site
288E, 289N, 290I, 310R, 360L, 361G, 362V, 381T, 462S, 492S
CDD
cd00831 (CHS_like)

289N

product binding site
288E, 289N, 290I, 310R, 360L, 361G, 362V, 381T, 462S, 492S
CDD
cd00831 (CHS_like)

290I

product binding site
288E, 289N, 290I, 310R, 360L, 361G, 362V, 381T, 462S, 492S
CDD
cd00831 (CHS_like)

310R

product binding site
288E, 289N, 290I, 310R, 360L, 361G, 362V, 381T, 462S, 492S
CDD
cd00831 (CHS_like)

360L

product binding site
288E, 289N, 290I, 310R, 360L, 361G, 362V, 381T, 462S, 492S
CDD
cd00831 (CHS_like)

361G

product binding site
288E, 289N, 290I, 310R, 360L, 361G, 362V, 381T, 462S, 492S
CDD
cd00831 (CHS_like)

362V

product binding site
288E, 289N, 290I, 310R, 360L, 361G, 362V, 381T, 462S, 492S
CDD
cd00831 (CHS_like)

381T

product binding site
288E, 289N, 290I, 310R, 360L, 361G, 362V, 381T, 462S, 492S
CDD
cd00831 (CHS_like)

462S

product binding site
288E, 289N, 290I, 310R, 360L, 361G, 362V, 381T, 462S, 492S
CDD
cd00831 (CHS_like)

492S

product binding site
288E, 289N, 290I, 310R, 360L, 361G, 362V, 381T, 462S, 492S
CDD
cd00831 (CHS_like)

GO term prediction

Biological Process

GO:0006633 fatty acid biosynthetic process

Molecular Function

GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups

Cellular Component

GO:0016020 membrane

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Entry type

Status

Per-residue features