Mp5g01220.1

Protein

Length

821 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
151 - 260
PAS domain superfamily (IPR035965)
326 - 519
Histidine kinase/HSP90-like ATPase superfamily (IPR036890)
Homologous superfamily
257 - 338
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (IPR036097)
544 - 668
CheY-like superfamily (IPR011006)

1 100 200 300 400 500 600 700 821

Domains and repeats

Domain
43 - 107
PAS domain (IPR000014)
131 - 258
PAS domain (IPR000014)
269 - 337
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (IPR003661)
443 - 457
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
461 - 471
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
478 - 496
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
502 - 515
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
543 - 665
Signal transduction response regulator, receiver domain (IPR001789)
Domain
278 - 518
Histidine kinase domain (IPR005467)
Domain
384 - 518
Histidine kinase/HSP90-like ATPase (IPR003594)

1 100 200 300 400 500 600 700 821

Detailed signature matches

IPR035965

PAS domain superfamily
1. SSF55785 (PYP-like ...)
  
  151 - 260
  
  SUPERFAMILY
  SSF55785 (PYP-like sensor domain (PAS domain))
IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
1. SSF47384 (Homodimer...)
  
  257 - 338
  
  SUPERFAMILY
  SSF47384 (Homodimeric domain of signal transducing histidine kinase)
IPR036890

Histidine kinase/HSP90-like ATPase superfamily
1. G3DSA:3.30.56...
  
  338 - 519
  
  GENE3D
  G3DSA:3.30.565.10 (G3DSA:3.30.565.10)
2. SSF55874 (ATPase do...)
  
  326 - 514
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
IPR011006

CheY-like superfamily
1. SSF52172 (CheY-like)
  
  544 - 668
  
  SUPERFAMILY
  SSF52172 (CheY-like)
IPR000014

PAS domain
1. cd00130 (PAS)
  
  152 - 248
  
  CDD
  cd00130 (PAS)
2. TIGR00229
  
  131 - 258
  
  TIGRFAMs
  TIGR00229 (TIGR00229)
3. PF13426 (PAS_9)
  
  43 - 107
  
  Pfam
  PF13426 (PAS_9)
  
  146 - 250
  
  Pfam
  PF13426 (PAS_9)
IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
1. cd00082 (HisKA)
  
  269 - 332
  
  CDD
  cd00082 (HisKA)
2. SM00388 (HisKA_10)
  
  271 - 337
  
  SMART
  SM00388 (HisKA_10)
3. PF00512 (HisKA)
  
  271 - 336
  
  Pfam
  PF00512 (HisKA)
IPR005467

Histidine kinase domain
1. PS50109 (HIS_KIN)
  
  278 - 518
  
  PROSITE profiles
  PS50109 (HIS_KIN)
IPR003594

Histidine kinase/HSP90-like ATPase
1. PF02518 (HATPase_c)
  
  384 - 516
  
  Pfam
  PF02518 (HATPase_c)
2. SM00387 (HKATPase_4)
  
  384 - 518
  
  SMART
  SM00387 (HKATPase_4)
IPR004358

Signal transduction histidine kinase-related protein, C-terminal
1. PR00344 (BCTRLSENSOR)
  
  461 - 471
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  443 - 457
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  502 - 515
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  478 - 496
  
  PRINTS
  PR00344 (BCTRLSENSOR)
IPR001789

Signal transduction response regulator, receiver domain
1. PS50110 (RESPONSE_R...)
  
  544 - 665
  
  PROSITE profiles
  PS50110 (RESPONSE_REGULATORY)
2. PF00072 (Response_reg)
  
  545 - 661
  
  Pfam
  PF00072 (Response_reg)
3. SM00448 (REC_2)
  
  543 - 661
  
  SMART
  SM00448 (REC_2)

no IPR

Unintegrated signatures

G3DSA:1.10.28...

243 - 335

GENE3D
G3DSA:1.10.287.130 (G3DSA:1.10.287.130)
G3DSA:3.30.45...

126 - 242

GENE3D
G3DSA:3.30.450.20 (G3DSA:3.30.450.20)
G3DSA:3.40.50...

535 - 674

GENE3D
G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)
PTHR45339 (HYBRID S...)

247 - 517

PANTHER
PTHR45339 (HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J)

541 - 685

PANTHER
PTHR45339 (HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J)
cd17546 (REC_hyHK_C...)

545 - 661

CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

Other features

Coil

251 - 271

COILS
Coil (Coil)

Residue annotation

putative active si...

158C

putative active site
158C, 162T, 168R, 182F, 183S, 184P, 185P, 216H, 221G
CDD
cd00130 (PAS)

162T

putative active site
158C, 162T, 168R, 182F, 183S, 184P, 185P, 216H, 221G
CDD
cd00130 (PAS)

168R

putative active site
158C, 162T, 168R, 182F, 183S, 184P, 185P, 216H, 221G
CDD
cd00130 (PAS)

182F

putative active site
158C, 162T, 168R, 182F, 183S, 184P, 185P, 216H, 221G
CDD
cd00130 (PAS)

183S

putative active site
158C, 162T, 168R, 182F, 183S, 184P, 185P, 216H, 221G
CDD
cd00130 (PAS)

184P

putative active site
158C, 162T, 168R, 182F, 183S, 184P, 185P, 216H, 221G
CDD
cd00130 (PAS)

185P

putative active site
158C, 162T, 168R, 182F, 183S, 184P, 185P, 216H, 221G
CDD
cd00130 (PAS)

216H

putative active site
158C, 162T, 168R, 182F, 183S, 184P, 185P, 216H, 221G
CDD
cd00130 (PAS)

221G

putative active site
158C, 162T, 168R, 182F, 183S, 184P, 185P, 216H, 221G
CDD
cd00130 (PAS)
heme pocket cd00130

179P

heme pocket
179P, 183S, 196K, 199D, 200V, 228V, 230L
CDD
cd00130 (PAS)

183S

heme pocket
179P, 183S, 196K, 199D, 200V, 228V, 230L
CDD
cd00130 (PAS)

196K

heme pocket
179P, 183S, 196K, 199D, 200V, 228V, 230L
CDD
cd00130 (PAS)

199D

heme pocket
179P, 183S, 196K, 199D, 200V, 228V, 230L
CDD
cd00130 (PAS)

200V

heme pocket
179P, 183S, 196K, 199D, 200V, 228V, 230L
CDD
cd00130 (PAS)

228V

heme pocket
179P, 183S, 196K, 199D, 200V, 228V, 230L
CDD
cd00130 (PAS)

230L

heme pocket
179P, 183S, 196K, 199D, 200V, 228V, 230L
CDD
cd00130 (PAS)
dimer interface cd...

275F

dimer interface
275F, 279M, 283I, 286P, 290V, 293M, 310D, 314I, 317C, 321L, 324L, 328V
CDD
cd00082 (HisKA)

279M

dimer interface
275F, 279M, 283I, 286P, 290V, 293M, 310D, 314I, 317C, 321L, 324L, 328V
CDD
cd00082 (HisKA)

283I

dimer interface
275F, 279M, 283I, 286P, 290V, 293M, 310D, 314I, 317C, 321L, 324L, 328V
CDD
cd00082 (HisKA)

286P

dimer interface
275F, 279M, 283I, 286P, 290V, 293M, 310D, 314I, 317C, 321L, 324L, 328V
CDD
cd00082 (HisKA)

290V

dimer interface
275F, 279M, 283I, 286P, 290V, 293M, 310D, 314I, 317C, 321L, 324L, 328V
CDD
cd00082 (HisKA)

293M

dimer interface
275F, 279M, 283I, 286P, 290V, 293M, 310D, 314I, 317C, 321L, 324L, 328V
CDD
cd00082 (HisKA)

310D

dimer interface
275F, 279M, 283I, 286P, 290V, 293M, 310D, 314I, 317C, 321L, 324L, 328V
CDD
cd00082 (HisKA)

314I

dimer interface
275F, 279M, 283I, 286P, 290V, 293M, 310D, 314I, 317C, 321L, 324L, 328V
CDD
cd00082 (HisKA)

317C

dimer interface
275F, 279M, 283I, 286P, 290V, 293M, 310D, 314I, 317C, 321L, 324L, 328V
CDD
cd00082 (HisKA)

321L

dimer interface
275F, 279M, 283I, 286P, 290V, 293M, 310D, 314I, 317C, 321L, 324L, 328V
CDD
cd00082 (HisKA)

324L

dimer interface
275F, 279M, 283I, 286P, 290V, 293M, 310D, 314I, 317C, 321L, 324L, 328V
CDD
cd00082 (HisKA)

328V

dimer interface
275F, 279M, 283I, 286P, 290V, 293M, 310D, 314I, 317C, 321L, 324L, 328V
CDD
cd00082 (HisKA)
phosphorylation si...

281H

phosphorylation site
281H
CDD
cd00082 (HisKA)
metal binding site...

549E

metal binding site
549E, 550D, 594D
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

550D

metal binding site
549E, 550D, 594D
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

594D

metal binding site
549E, 550D, 594D
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)
Hpt domain binding...

551N

Hpt domain binding site
551N, 553V, 554N, 556I, 557V, 560R, 561T, 564A, 629A, 651P, 653D, 654L
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

553V

Hpt domain binding site
551N, 553V, 554N, 556I, 557V, 560R, 561T, 564A, 629A, 651P, 653D, 654L
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

554N

Hpt domain binding site
551N, 553V, 554N, 556I, 557V, 560R, 561T, 564A, 629A, 651P, 653D, 654L
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

556I

Hpt domain binding site
551N, 553V, 554N, 556I, 557V, 560R, 561T, 564A, 629A, 651P, 653D, 654L
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

557V

Hpt domain binding site
551N, 553V, 554N, 556I, 557V, 560R, 561T, 564A, 629A, 651P, 653D, 654L
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

560R

Hpt domain binding site
551N, 553V, 554N, 556I, 557V, 560R, 561T, 564A, 629A, 651P, 653D, 654L
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

561T

Hpt domain binding site
551N, 553V, 554N, 556I, 557V, 560R, 561T, 564A, 629A, 651P, 653D, 654L
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

564A

Hpt domain binding site
551N, 553V, 554N, 556I, 557V, 560R, 561T, 564A, 629A, 651P, 653D, 654L
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

629A

Hpt domain binding site
551N, 553V, 554N, 556I, 557V, 560R, 561T, 564A, 629A, 651P, 653D, 654L
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

651P

Hpt domain binding site
551N, 553V, 554N, 556I, 557V, 560R, 561T, 564A, 629A, 651P, 653D, 654L
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

653D

Hpt domain binding site
551N, 553V, 554N, 556I, 557V, 560R, 561T, 564A, 629A, 651P, 653D, 654L
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

654L

Hpt domain binding site
551N, 553V, 554N, 556I, 557V, 560R, 561T, 564A, 629A, 651P, 653D, 654L
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

GO term prediction

Biological Process

GO:0000160 phosphorelay signal transduction system
GO:0007165 signal transduction
GO:0016310 phosphorylation

Molecular Function

GO:0000155 phosphorelay sensor kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component