Mp6g14650.1

Protein

Length

2,440 amino acids

Protein family membership

Serine/threonine-protein kinase TOR (IPR026683)

Homologous superfamilies

Homologous superfamily
4 - 1,392
Armadillo-type fold (IPR016024)
1,986 - 2,323
Protein kinase-like domain superfamily (IPR011009)
Homologous superfamily
193 - 407
Armadillo-like helical (IPR011989)
595 - 773
Armadillo-like helical (IPR011989)
927 - 1,087
Armadillo-like helical (IPR011989)
1,907 - 2,004
FKBP12-rapamycin binding domain superfamily (IPR036738)
2,172 - 2,350
Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily (IPR036940)

1 500 1000 1500 2000 2440

Domains and repeats

Domain
722 - 894
Domain of unknown function DUF3385, target of rapamycin protein (IPR024585)
2,408 - 2,440
FATC domain (IPR003152)
Domain
1,270 - 1,871
PIK-related kinase (IPR014009)
PIK-related kinase, FAT (IPR003151)
1,904 - 2,002
FKBP12-rapamycin binding domain (IPR009076)
2,071 - 2,440
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)

1 500 1000 1500 2000 2440

Detailed signature matches

IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  523 - 768
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  431 - 487
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  817 - 1,101
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,170 - 1,392
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  333 - 396
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  4 - 484
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR011989

Armadillo-like helical
1. G3DSA:1.25.10.10
  
  595 - 773
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  193 - 407
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
  
  927 - 1,087
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
IPR036738

FKBP12-rapamycin binding domain superfamily
1. SSF47212 (FKBP12-ra...)
  
  1,908 - 2,002
  
  SUPERFAMILY
  SSF47212 (FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP))
2. G3DSA:1.20.12...
  
  1,907 - 2,004
  
  GENE3D
  G3DSA:1.20.120.150 (G3DSA:1.20.120.150)
IPR011009

Protein kinase-like domain superfamily
1. SSF56112 (Protein k...)
  
  1,986 - 2,149
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  2,184 - 2,323
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR036940

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
1. G3DSA:1.10.10...
  
  2,172 - 2,350
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
IPR026683

Serine/threonine-protein kinase TOR
1. PTHR11139:SF112 (SE...)
  
  6 - 2,438
  
  PANTHER
  PTHR11139:SF112 (SERINE/THREONINE-PROTEIN KINASE TOR)
IPR024585

Domain of unknown function DUF3385, target of rapamycin protein
1. PF11865 (DUF3385)
  
  722 - 894
  
  Pfam
  PF11865 (DUF3385)
2. SM01346 (DUF3385_3)
  
  722 - 894
  
  SMART
  SM01346 (DUF3385_3)
IPR014009

PIK-related kinase
1. PS51189 (FAT)
  
  1,270 - 1,871
  
  PROSITE profiles
  PS51189 (FAT)
IPR003151

PIK-related kinase, FAT
1. PF02259 (FAT)
  
  1,409 - 1,797
  
  Pfam
  PF02259 (FAT)
IPR009076

FKBP12-rapamycin binding domain
1. PF08771 (FRB_dom)
  
  1,904 - 2,002
  
  Pfam
  PF08771 (FRB_dom)
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. PS50290 (PI3_4_KINA...)
  
  2,072 - 2,440
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
2. SM00146 (pi3k_hr1_6)
  
  2,073 - 2,375
  
  SMART
  SM00146 (pi3k_hr1_6)
3. PF00454 (PI3_PI4_ki...)
  
  2,071 - 2,320
  
  Pfam
  PF00454 (PI3_PI4_kinase)
IPR003152

FATC domain
1. SM01343 (FATC_2)
  
  2,408 - 2,440
  
  SMART
  SM01343 (FATC_2)
2. PF02260 (FATC)
  
  2,410 - 2,440
  
  Pfam
  PF02260 (FATC)
3. PS51190 (FATC)
  
  2,408 - 2,440
  
  PROSITE profiles
  PS51190 (FATC)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00916 (PI3_4_KINA...)
  
  2,213 - 2,233
  
  PROSITE patterns
  PS00916 (PI3_4_KINASE_2)
2. PS00915 (PI3_4_KINA...)
  
  2,076 - 2,090
  
  PROSITE patterns
  PS00915 (PI3_4_KINASE_1)

no IPR

Unintegrated signatures

G3DSA:3.30.10...

2,038 - 2,130

GENE3D
G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
PTHR11139 (ATAXIA T...)

6 - 2,438

PANTHER
PTHR11139 (ATAXIA TELANGIECTASIA MUTATED ATM -RELATED)
SM01345 (Rapamycin_...)

1,904 - 2,004

SMART
SM01345 (Rapamycin_bind_3)
cd05169 (PIKKc_TOR)

2,043 - 2,321

CDD
cd05169 (PIKKc_TOR)

Other features

Coil

2,136 - 2,156

COILS
Coil (Coil)

1,338 - 1,365

COILS
Coil (Coil)

Residue annotation

ATP binding site c...

2,053I

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,055S

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,056K

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,057Q

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,059P

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,075L

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,077K

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,080E

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,115Y

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,127I

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,128G

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,129W

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,130V

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,135T

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,233N

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,235M

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,246I

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)

2,247D

ATP binding site
2,053I, 2,055S, 2,056K, 2,057Q, 2,059P, 2,075L, 2,077K, 2,080E, 2,115Y, 2,127I, 2,128G, 2,129W, 2,130V, 2,135T, 2,233N, 2,235M, 2,246I, 2,247D
CDD
cd05169 (PIKKc_TOR)
mLST8 interface cd...

2,162A

mLST8 interface
2,162A, 2,163P, 2,164D, 2,167H, 2,168L, 2,169T, 2,170L, 2,172A, 2,174V, 2,175E, 2,178E
CDD
cd05169 (PIKKc_TOR)

2,163P

mLST8 interface
2,162A, 2,163P, 2,164D, 2,167H, 2,168L, 2,169T, 2,170L, 2,172A, 2,174V, 2,175E, 2,178E
CDD
cd05169 (PIKKc_TOR)

2,164D

mLST8 interface
2,162A, 2,163P, 2,164D, 2,167H, 2,168L, 2,169T, 2,170L, 2,172A, 2,174V, 2,175E, 2,178E
CDD
cd05169 (PIKKc_TOR)

2,167H

mLST8 interface
2,162A, 2,163P, 2,164D, 2,167H, 2,168L, 2,169T, 2,170L, 2,172A, 2,174V, 2,175E, 2,178E
CDD
cd05169 (PIKKc_TOR)

2,168L

mLST8 interface
2,162A, 2,163P, 2,164D, 2,167H, 2,168L, 2,169T, 2,170L, 2,172A, 2,174V, 2,175E, 2,178E
CDD
cd05169 (PIKKc_TOR)

2,169T

mLST8 interface
2,162A, 2,163P, 2,164D, 2,167H, 2,168L, 2,169T, 2,170L, 2,172A, 2,174V, 2,175E, 2,178E
CDD
cd05169 (PIKKc_TOR)

2,170L

mLST8 interface
2,162A, 2,163P, 2,164D, 2,167H, 2,168L, 2,169T, 2,170L, 2,172A, 2,174V, 2,175E, 2,178E
CDD
cd05169 (PIKKc_TOR)

2,172A

mLST8 interface
2,162A, 2,163P, 2,164D, 2,167H, 2,168L, 2,169T, 2,170L, 2,172A, 2,174V, 2,175E, 2,178E
CDD
cd05169 (PIKKc_TOR)

2,174V

mLST8 interface
2,162A, 2,163P, 2,164D, 2,167H, 2,168L, 2,169T, 2,170L, 2,172A, 2,174V, 2,175E, 2,178E
CDD
cd05169 (PIKKc_TOR)

2,175E

mLST8 interface
2,162A, 2,163P, 2,164D, 2,167H, 2,168L, 2,169T, 2,170L, 2,172A, 2,174V, 2,175E, 2,178E
CDD
cd05169 (PIKKc_TOR)

2,178E

mLST8 interface
2,162A, 2,163P, 2,164D, 2,167H, 2,168L, 2,169T, 2,170L, 2,172A, 2,174V, 2,175E, 2,178E
CDD
cd05169 (PIKKc_TOR)
catalytic loop cd0...

2,225G

catalytic loop
2,225G, 2,226L, 2,227G, 2,228D, 2,229R, 2,230H, 2,231P, 2,232S, 2,233N
CDD
cd05169 (PIKKc_TOR)

2,226L

catalytic loop
2,225G, 2,226L, 2,227G, 2,228D, 2,229R, 2,230H, 2,231P, 2,232S, 2,233N
CDD
cd05169 (PIKKc_TOR)

2,227G

catalytic loop
2,225G, 2,226L, 2,227G, 2,228D, 2,229R, 2,230H, 2,231P, 2,232S, 2,233N
CDD
cd05169 (PIKKc_TOR)

2,228D

catalytic loop
2,225G, 2,226L, 2,227G, 2,228D, 2,229R, 2,230H, 2,231P, 2,232S, 2,233N
CDD
cd05169 (PIKKc_TOR)

2,229R

catalytic loop
2,225G, 2,226L, 2,227G, 2,228D, 2,229R, 2,230H, 2,231P, 2,232S, 2,233N
CDD
cd05169 (PIKKc_TOR)

2,230H

catalytic loop
2,225G, 2,226L, 2,227G, 2,228D, 2,229R, 2,230H, 2,231P, 2,232S, 2,233N
CDD
cd05169 (PIKKc_TOR)

2,231P

catalytic loop
2,225G, 2,226L, 2,227G, 2,228D, 2,229R, 2,230H, 2,231P, 2,232S, 2,233N
CDD
cd05169 (PIKKc_TOR)

2,232S

catalytic loop
2,225G, 2,226L, 2,227G, 2,228D, 2,229R, 2,230H, 2,231P, 2,232S, 2,233N
CDD
cd05169 (PIKKc_TOR)

2,233N

catalytic loop
2,225G, 2,226L, 2,227G, 2,228D, 2,229R, 2,230H, 2,231P, 2,232S, 2,233N
CDD
cd05169 (PIKKc_TOR)
activation loop (A...

2,247D

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,248F

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,249G

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,250D

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,251C

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,252F

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,253E

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,254A

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,255S

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,256M

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,257N

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,258R

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,259E

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,260K

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,261F

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,262P

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,263E

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,264K

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,265V

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,266P

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,267F

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,268R

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,269L

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

2,270T

activation loop (A-loop)
2,247D, 2,248F, 2,249G, 2,250D, 2,251C, 2,252F, 2,253E, 2,254A, 2,255S, 2,256M, 2,257N, 2,258R, 2,259E, 2,260K, 2,261F, 2,262P, 2,263E, 2,264K, 2,265V, 2,266P, 2,267F, 2,268R, 2,269L, 2,270T
CDD
cd05169 (PIKKc_TOR)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0044877 protein-containing complex binding

Cellular Component