Mp8g08900.1

Protein

Length

1,185 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
465 - 545
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily (IPR036097)
Homologous superfamily
533 - 772
Histidine kinase/HSP90-like ATPase superfamily (IPR036890)
1,052 - 1,175
CheY-like superfamily (IPR011006)

1 200 400 600 800 1000 1185

Domains and repeats

Domain
152 - 435
MASE1 (IPR007895)
486 - 774
Histidine kinase domain (IPR005467)
1,053 - 1,175
Signal transduction response regulator, receiver domain (IPR001789)
Domain
477 - 544
Signal transduction histidine kinase, dimerisation/phosphoacceptor domain (IPR003661)
591 - 774
Histidine kinase/HSP90-like ATPase (IPR003594)
Domain
699 - 713
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
717 - 727
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
734 - 752
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)
758 - 771
Signal transduction histidine kinase-related protein, C-terminal (IPR004358)

1 200 400 600 800 1000 1185

Detailed signature matches

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
1. SSF47384 (Homodimer...)
  
  465 - 545
  
  SUPERFAMILY
  SSF47384 (Homodimeric domain of signal transducing histidine kinase)
IPR036890

Histidine kinase/HSP90-like ATPase superfamily
1. SSF55874 (ATPase do...)
  
  698 - 772
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
  
  533 - 625
  
  SUPERFAMILY
  SSF55874 (ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase)
IPR011006

CheY-like superfamily
1. SSF52172 (CheY-like)
  
  1,052 - 1,175
  
  SUPERFAMILY
  SSF52172 (CheY-like)
IPR007895

MASE1
1. PF05231 (MASE1)
  
  152 - 435
  
  Pfam
  PF05231 (MASE1)
IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain
1. cd00082 (HisKA)
  
  477 - 540
  
  CDD
  cd00082 (HisKA)
2. SM00388 (HisKA_10)
  
  479 - 544
  
  SMART
  SM00388 (HisKA_10)
3. PF00512 (HisKA)
  
  479 - 544
  
  Pfam
  PF00512 (HisKA)
IPR005467

Histidine kinase domain
1. PS50109 (HIS_KIN)
  
  486 - 774
  
  PROSITE profiles
  PS50109 (HIS_KIN)
IPR003594

Histidine kinase/HSP90-like ATPase
1. PF02518 (HATPase_c)
  
  591 - 772
  
  Pfam
  PF02518 (HATPase_c)
2. SM00387 (HKATPase_4)
  
  591 - 774
  
  SMART
  SM00387 (HKATPase_4)
IPR004358

Signal transduction histidine kinase-related protein, C-terminal
1. PR00344 (BCTRLSENSOR)
  
  734 - 752
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  758 - 771
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  699 - 713
  
  PRINTS
  PR00344 (BCTRLSENSOR)
  
  717 - 727
  
  PRINTS
  PR00344 (BCTRLSENSOR)
IPR001789

Signal transduction response regulator, receiver domain
1. PS50110 (RESPONSE_R...)
  
  1,054 - 1,175
  
  PROSITE profiles
  PS50110 (RESPONSE_REGULATORY)
2. PF00072 (Response_reg)
  
  1,055 - 1,171
  
  Pfam
  PF00072 (Response_reg)
3. SM00448 (REC_2)
  
  1,053 - 1,171
  
  SMART
  SM00448 (REC_2)

no IPR

Unintegrated signatures

G3DSA:1.10.28...

431 - 542

GENE3D
G3DSA:1.10.287.130 (G3DSA:1.10.287.130)
G3DSA:3.40.50...

1,035 - 1,175

GENE3D
G3DSA:3.40.50.2300 (G3DSA:3.40.50.2300)
PTHR45530 (SENSORY ...)

111 - 1,177

PANTHER
PTHR45530 (SENSORY TRANSDUCTION HISTIDINE KINASE)
cd16922 (HATPase_Ev...)

596 - 772

CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)
cd17546 (REC_hyHK_C...)

1,055 - 1,171

CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

Other features

Coil

459 - 479

COILS
Coil (Coil)

427 - 454

COILS
Coil (Coil)
mobidb-lite (disord...)

621 - 663

MobiDB Lite
mobidb-lite (disorder_prediction)

1,013 - 1,044

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Polar)

639 - 663

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

Residue annotation

dimer interface cd...

483F

dimer interface
483F, 487M, 491I, 494P, 498I, 501L, 517S, 521V, 524C, 528L, 531I, 535I
CDD
cd00082 (HisKA)

487M

dimer interface
483F, 487M, 491I, 494P, 498I, 501L, 517S, 521V, 524C, 528L, 531I, 535I
CDD
cd00082 (HisKA)

491I

dimer interface
483F, 487M, 491I, 494P, 498I, 501L, 517S, 521V, 524C, 528L, 531I, 535I
CDD
cd00082 (HisKA)

494P

dimer interface
483F, 487M, 491I, 494P, 498I, 501L, 517S, 521V, 524C, 528L, 531I, 535I
CDD
cd00082 (HisKA)

498I

dimer interface
483F, 487M, 491I, 494P, 498I, 501L, 517S, 521V, 524C, 528L, 531I, 535I
CDD
cd00082 (HisKA)

501L

dimer interface
483F, 487M, 491I, 494P, 498I, 501L, 517S, 521V, 524C, 528L, 531I, 535I
CDD
cd00082 (HisKA)

517S

dimer interface
483F, 487M, 491I, 494P, 498I, 501L, 517S, 521V, 524C, 528L, 531I, 535I
CDD
cd00082 (HisKA)

521V

dimer interface
483F, 487M, 491I, 494P, 498I, 501L, 517S, 521V, 524C, 528L, 531I, 535I
CDD
cd00082 (HisKA)

524C

dimer interface
483F, 487M, 491I, 494P, 498I, 501L, 517S, 521V, 524C, 528L, 531I, 535I
CDD
cd00082 (HisKA)

528L

dimer interface
483F, 487M, 491I, 494P, 498I, 501L, 517S, 521V, 524C, 528L, 531I, 535I
CDD
cd00082 (HisKA)

531I

dimer interface
483F, 487M, 491I, 494P, 498I, 501L, 517S, 521V, 524C, 528L, 531I, 535I
CDD
cd00082 (HisKA)

535I

dimer interface
483F, 487M, 491I, 494P, 498I, 501L, 517S, 521V, 524C, 528L, 531I, 535I
CDD
cd00082 (HisKA)
phosphorylation si...

489H

phosphorylation site
489H
CDD
cd00082 (HisKA)
ATP binding site c...

602N

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

606N

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

609K

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

686V

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

705D

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

707G

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

709G

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

710V

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

737G

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

738L

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

739G

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

740L

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

756A

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

758S

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

763G

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

764S

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

766F

ATP binding site
602N, 606N, 609K, 686V, 705D, 707G, 709G, 710V, 737G, 738L, 739G, 740L, 756A, 758S, 763G, 764S, 766F
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)
ATP-lid cd16922

719F

ATP-lid
719F, 740L
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)

740L

ATP-lid
719F, 740L
CDD
cd16922 (HATPase_EvgS-ArcB-TorS-like)
Hpt domain binding...

1,061N

Hpt domain binding site
1,061N, 1,063V, 1,064N, 1,066K, 1,067V, 1,070R, 1,071Q, 1,074K, 1,139A, 1,161P, 1,163D, 1,164I
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,063V

Hpt domain binding site
1,061N, 1,063V, 1,064N, 1,066K, 1,067V, 1,070R, 1,071Q, 1,074K, 1,139A, 1,161P, 1,163D, 1,164I
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,064N

Hpt domain binding site
1,061N, 1,063V, 1,064N, 1,066K, 1,067V, 1,070R, 1,071Q, 1,074K, 1,139A, 1,161P, 1,163D, 1,164I
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,066K

Hpt domain binding site
1,061N, 1,063V, 1,064N, 1,066K, 1,067V, 1,070R, 1,071Q, 1,074K, 1,139A, 1,161P, 1,163D, 1,164I
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,067V

Hpt domain binding site
1,061N, 1,063V, 1,064N, 1,066K, 1,067V, 1,070R, 1,071Q, 1,074K, 1,139A, 1,161P, 1,163D, 1,164I
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,070R

Hpt domain binding site
1,061N, 1,063V, 1,064N, 1,066K, 1,067V, 1,070R, 1,071Q, 1,074K, 1,139A, 1,161P, 1,163D, 1,164I
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,071Q

Hpt domain binding site
1,061N, 1,063V, 1,064N, 1,066K, 1,067V, 1,070R, 1,071Q, 1,074K, 1,139A, 1,161P, 1,163D, 1,164I
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,074K

Hpt domain binding site
1,061N, 1,063V, 1,064N, 1,066K, 1,067V, 1,070R, 1,071Q, 1,074K, 1,139A, 1,161P, 1,163D, 1,164I
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,139A

Hpt domain binding site
1,061N, 1,063V, 1,064N, 1,066K, 1,067V, 1,070R, 1,071Q, 1,074K, 1,139A, 1,161P, 1,163D, 1,164I
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,161P

Hpt domain binding site
1,061N, 1,063V, 1,064N, 1,066K, 1,067V, 1,070R, 1,071Q, 1,074K, 1,139A, 1,161P, 1,163D, 1,164I
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,163D

Hpt domain binding site
1,061N, 1,063V, 1,064N, 1,066K, 1,067V, 1,070R, 1,071Q, 1,074K, 1,139A, 1,161P, 1,163D, 1,164I
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

1,164I

Hpt domain binding site
1,061N, 1,063V, 1,064N, 1,066K, 1,067V, 1,070R, 1,071Q, 1,074K, 1,139A, 1,161P, 1,163D, 1,164I
CDD
cd17546 (REC_hyHK_CKI1_RcsC-like)

GO term prediction

Biological Process

GO:0000160 phosphorelay signal transduction system
GO:0007165 signal transduction
GO:0016310 phosphorylation

Molecular Function

GO:0000155 phosphorelay sensor kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component