Mp2g12950.1

Protein

Length

2,803 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
652 - 2,575
Armadillo-type fold (IPR016024)
2,600 - 2,760
Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily (IPR036940)
Homologous superfamily
1,019 - 1,283
Armadillo-like helical (IPR011989)
1,804 - 2,088
Tetratricopeptide-like helical domain superfamily (IPR011990)
2,423 - 2,735
Protein kinase-like domain superfamily (IPR011009)

1 500 1000 1500 2000 2500 2803

Domains and repeats

Domain
1,162 - 1,268
UME domain (IPR012993)
1,727 - 2,347
PIK-related kinase (IPR014009)
PIK-related kinase, FAT (IPR003151)
2,771 - 2,803
FATC domain (IPR003152)
Domain
2,481 - 2,803
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)

1 500 1000 1500 2000 2500 2803

Detailed signature matches

IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  1,054 - 1,143
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  652 - 757
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  814 - 1,020
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,375 - 1,487
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  2,273 - 2,389
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  2,488 - 2,575
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,609 - 1,681
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,121 - 1,291
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  2,228 - 2,241
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  998 - 1,077
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR011989

Armadillo-like helical
1. G3DSA:1.25.10.10
  
  1,019 - 1,283
  
  GENE3D
  G3DSA:1.25.10.10 (G3DSA:1.25.10.10)
IPR011990

Tetratricopeptide-like helical domain superfamily
1. SSF48452 (TPR-like)
  
  1,804 - 1,863
  
  SUPERFAMILY
  SSF48452 (TPR-like)
  
  2,028 - 2,088
  
  SUPERFAMILY
  SSF48452 (TPR-like)
IPR011009

Protein kinase-like domain superfamily
1. SSF56112 (Protein k...)
  
  2,423 - 2,558
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  2,597 - 2,735
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR036940

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
1. G3DSA:1.10.10...
  
  2,600 - 2,760
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
IPR012993

UME domain
1. PF08064 (UME)
  
  1,165 - 1,265
  
  Pfam
  PF08064 (UME)
2. SM00802 (UME_cls)
  
  1,162 - 1,268
  
  SMART
  SM00802 (UME_cls)
IPR014009

PIK-related kinase
1. PS51189 (FAT)
  
  1,727 - 2,347
  
  PROSITE profiles
  PS51189 (FAT)
IPR003151

PIK-related kinase, FAT
1. PF02259 (FAT)
  
  1,872 - 2,257
  
  Pfam
  PF02259 (FAT)
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. PS50290 (PI3_4_KINA...)
  
  2,481 - 2,803
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
2. SM00146 (pi3k_hr1_6)
  
  2,482 - 2,792
  
  SMART
  SM00146 (pi3k_hr1_6)
3. PF00454 (PI3_PI4_ki...)
  
  2,482 - 2,732
  
  Pfam
  PF00454 (PI3_PI4_kinase)
IPR003152

FATC domain
1. SM01343 (FATC_2)
  
  2,771 - 2,803
  
  SMART
  SM01343 (FATC_2)
2. PF02260 (FATC)
  
  2,774 - 2,803
  
  Pfam
  PF02260 (FATC)
3. PS51190 (FATC)
  
  2,771 - 2,803
  
  PROSITE profiles
  PS51190 (FATC)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00916 (PI3_4_KINA...)
  
  2,626 - 2,646
  
  PROSITE patterns
  PS00916 (PI3_4_KINASE_2)

no IPR

Unintegrated signatures

G3DSA:3.30.10...

2,426 - 2,539

GENE3D
G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
PTHR11139 (ATAXIA T...)

67 - 2,799

PANTHER
PTHR11139 (ATAXIA TELANGIECTASIA MUTATED ATM -RELATED)
PTHR11139:SF69 (SER...)

67 - 2,799

PANTHER
PTHR11139:SF69 (SERINE/THREONINE-PROTEIN KINASE ATR)
cd00892 (PIKKc_ATR)

2,452 - 2,733

CDD
cd00892 (PIKKc_ATR)

Other features

mobidb-lite (disord...)

1,487 - 1,511

MobiDB Lite
mobidb-lite (disorder_prediction)

1,682 - 1,705

MobiDB Lite
mobidb-lite (disorder_prediction)

428 - 459

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Polar)

1,487 - 1,501

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

430 - 453

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

Residue annotation

ATP binding site c...

2,462L

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,464S

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,465L

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,466Q

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,468P

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,484L

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,486K

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,489D

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,524F

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,536I

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,537E

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,538W

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,539V

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,544G

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,646N

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,648L

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,659V

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)

2,660D

ATP binding site
2,462L, 2,464S, 2,465L, 2,466Q, 2,468P, 2,484L, 2,486K, 2,489D, 2,524F, 2,536I, 2,537E, 2,538W, 2,539V, 2,544G, 2,646N, 2,648L, 2,659V, 2,660D
CDD
cd00892 (PIKKc_ATR)
catalytic loop cd0...

2,638G

catalytic loop
2,638G, 2,639L, 2,640G, 2,641D, 2,642R, 2,643H, 2,644G, 2,645E, 2,646N
CDD
cd00892 (PIKKc_ATR)

2,639L

catalytic loop
2,638G, 2,639L, 2,640G, 2,641D, 2,642R, 2,643H, 2,644G, 2,645E, 2,646N
CDD
cd00892 (PIKKc_ATR)

2,640G

catalytic loop
2,638G, 2,639L, 2,640G, 2,641D, 2,642R, 2,643H, 2,644G, 2,645E, 2,646N
CDD
cd00892 (PIKKc_ATR)

2,641D

catalytic loop
2,638G, 2,639L, 2,640G, 2,641D, 2,642R, 2,643H, 2,644G, 2,645E, 2,646N
CDD
cd00892 (PIKKc_ATR)

2,642R

catalytic loop
2,638G, 2,639L, 2,640G, 2,641D, 2,642R, 2,643H, 2,644G, 2,645E, 2,646N
CDD
cd00892 (PIKKc_ATR)

2,643H

catalytic loop
2,638G, 2,639L, 2,640G, 2,641D, 2,642R, 2,643H, 2,644G, 2,645E, 2,646N
CDD
cd00892 (PIKKc_ATR)

2,644G

catalytic loop
2,638G, 2,639L, 2,640G, 2,641D, 2,642R, 2,643H, 2,644G, 2,645E, 2,646N
CDD
cd00892 (PIKKc_ATR)

2,645E

catalytic loop
2,638G, 2,639L, 2,640G, 2,641D, 2,642R, 2,643H, 2,644G, 2,645E, 2,646N
CDD
cd00892 (PIKKc_ATR)

2,646N

catalytic loop
2,638G, 2,639L, 2,640G, 2,641D, 2,642R, 2,643H, 2,644G, 2,645E, 2,646N
CDD
cd00892 (PIKKc_ATR)
activation loop (A...

2,660D

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,661F

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,662S

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,663C

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,664L

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,665F

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,666D

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,667K

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,668G

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,669L

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,670Q

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,671L

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,672E

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,673K

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,674P

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,675E

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,676L

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,677V

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,678P

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,679F

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,680R

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,681L

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

2,682T

activation loop (A-loop)
2,660D, 2,661F, 2,662S, 2,663C, 2,664L, 2,665F, 2,666D, 2,667K, 2,668G, 2,669L, 2,670Q, 2,671L, 2,672E, 2,673K, 2,674P, 2,675E, 2,676L, 2,677V, 2,678P, 2,679F, 2,680R, 2,681L, 2,682T
CDD
cd00892 (PIKKc_ATR)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0016301 kinase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

Mp2g12950.1

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Other features

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component