Mp4g02970.2

Protein

Length

954 amino acids

Protein family membership

P-type ATPase (IPR001757)
- P-type ATPase, subfamily IIIA (IPR006534)

Homologous superfamilies

Homologous superfamily
19 - 136
P-type ATPase, transmembrane domain superfamily (IPR023298)
233 - 327
P-type ATPase, transmembrane domain superfamily (IPR023298)
329 - 385
HAD-like superfamily (IPR036412)
422 - 639
HAD-like superfamily (IPR036412)
641 - 851
P-type ATPase, transmembrane domain superfamily (IPR023298)
Homologous superfamily
137 - 233
P-type ATPase, A domain superfamily (IPR008250)
348 - 489
P-type ATPase, cytoplasmic domain N (IPR023299)
490 - 551
HAD superfamily (IPR023214)

1 100 200 300 400 500 600 700 800 900 954

Domains and repeats

Domain
19 - 91
Cation-transporting P-type ATPase, N-terminal (IPR004014)

1 100 200 300 400 500 600 700 800 900 954

Detailed signature matches

IPR023298

P-type ATPase, transmembrane domain superfamily
1. SSF81665 (Calcium A...)
  
  233 - 327
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  Model: 0049473
  
  641 - 851
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  Model: 0049473
  
  19 - 136
  
  SUPERFAMILY
  SSF81665 (Calcium ATPase, transmembrane domain M)
  Model: 0049473
IPR008250

P-type ATPase, A domain superfamily
1. SSF81653 (Calcium A...)
  
  137 - 233
  
  SUPERFAMILY
  SSF81653 (Calcium ATPase, transduction domain A)
  Model: 0049471
IPR036412

HAD-like superfamily
1. SSF56784 (HAD-like)
  
  422 - 639
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  Model: 0048428
  
  329 - 385
  
  SUPERFAMILY
  SSF56784 (HAD-like)
  Model: 0048428
IPR023299

P-type ATPase, cytoplasmic domain N
1. G3DSA:3.40.11...
  
  348 - 489
  
  GENE3D
  G3DSA:3.40.1110.10 (G3DSA:3.40.1110.10)
  Model: 3b8cA04
IPR023214

HAD superfamily
1. G3DSA:3.40.50...
  
  490 - 551
  
  GENE3D
  G3DSA:3.40.50.1000 (G3DSA:3.40.50.1000)
  Model: 3wguA03
IPR001757

P-type ATPase
1. TIGR01494
  
  105 - 353
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
  
  567 - 678
  
  TIGRFAMs
  TIGR01494 (TIGR01494)
2. PR00120 (HATPASE)
  
  592 - 608
  
  PRINTS
  PR00120 (HATPASE)
  
  564 - 580
  
  PRINTS
  PR00120 (HATPASE)
  
  764 - 785
  
  PRINTS
  PR00120 (HATPASE)
  
  449 - 467
  
  PRINTS
  PR00120 (HATPASE)
  
  623 - 648
  
  PRINTS
  PR00120 (HATPASE)
IPR006534

P-type ATPase, subfamily IIIA
1. TIGR01647
  
  38 - 810
  
  TIGRFAMs
  TIGR01647 (TIGR01647)
2. cd02076 (P-type_ATP...)
  
  38 - 845
  
  CDD
  cd02076 (P-type_ATPase_H)
IPR004014

Cation-transporting P-type ATPase, N-terminal
1. PF00690 (Cation_ATP...)
  
  22 - 85
  
  Pfam
  PF00690 (Cation_ATPase_N)
2. SM00831 (Cation_ATP...)
  
  19 - 91
  
  SMART
  SM00831 (Cation_ATPase_N_a_2)
IPR018303

P-type ATPase, phosphorylation site
1. PS00154 (ATPASE_E1_E2)
  
  335 - 341
  
  PROSITE patterns
  PS00154 (ATPASE_E1_E2)

no IPR

Unintegrated signatures

G3DSA:1.20.11...

571 - 850

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
Model: 3b8cA01

68 - 161

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
Model: 3b8cA01

198 - 347

GENE3D
G3DSA:1.20.1110.10 (G3DSA:1.20.1110.10)
Model: 1wpgA02
PF00122 (E1-E2_ATPase)

134 - 313

Pfam
PF00122 (E1-E2_ATPase)
PF00702 (Hydrolase)

329 - 606

Pfam
PF00702 (Hydrolase)
PR00119 (CATATPASE)

615 - 627

PRINTS
PR00119 (CATATPASE)

183 - 197

PRINTS
PR00119 (CATATPASE)

487 - 498

PRINTS
PR00119 (CATATPASE)

333 - 347

PRINTS
PR00119 (CATATPASE)

592 - 611

PRINTS
PR00119 (CATATPASE)

509 - 519

PRINTS
PR00119 (CATATPASE)
SFLDF00027 (p-type_...)

315 - 643

SFLD
SFLDF00027 (p-type_atpase)
SFLDG00002 (C1.7:_P...)

315 - 643

SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)

Other features

Coil

905 - 925

COILS
Coil (Coil)

Residue annotation

SFLDF00027

335D

nucleophile: attacks gamma phosphate moiety of ATP to form covalent intermediate, Mg2+ ligand
335D
SFLD
SFLDF00027 (p-type_atpase)
SFLDG00002

335D

nucleophile: attacks gamma phosphate moiety of ATP to form covalent intermediate, Mg2+ ligand
335D
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)
phosphorylation si...

335D

phosphorylation site
335D
CDD
cd02076 (P-type_ATPase_H)
P-type ATPase sign...

335D

P-type ATPase signature motif
335D, 336K, 337T, 338G, 339T, 340L, 341T
CDD
cd02076 (P-type_ATPase_H)

336K

P-type ATPase signature motif
335D, 336K, 337T, 338G, 339T, 340L, 341T
CDD
cd02076 (P-type_ATPase_H)

337T

P-type ATPase signature motif
335D, 336K, 337T, 338G, 339T, 340L, 341T
CDD
cd02076 (P-type_ATPase_H)

338G

P-type ATPase signature motif
335D, 336K, 337T, 338G, 339T, 340L, 341T
CDD
cd02076 (P-type_ATPase_H)

339T

P-type ATPase signature motif
335D, 336K, 337T, 338G, 339T, 340L, 341T
CDD
cd02076 (P-type_ATPase_H)

340L

P-type ATPase signature motif
335D, 336K, 337T, 338G, 339T, 340L, 341T
CDD
cd02076 (P-type_ATPase_H)

341T

P-type ATPase signature motif
335D, 336K, 337T, 338G, 339T, 340L, 341T
CDD
cd02076 (P-type_ATPase_H)
ATP binding site c...

335D

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

336K

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

337T

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

380I

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

381D

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

406F

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

411K

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

413T

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

429K

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

430G

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

462R

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

463S

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

516I

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

517T

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

518G

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

519D

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

569G

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

575K

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

594D

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)

597N

ATP binding site
335D, 336K, 337T, 380I, 381D, 406F, 411K, 413T, 429K, 430G, 462R, 463S, 516I, 517T, 518G, 519D, 569G, 575K, 594D, 597N
CDD
cd02076 (P-type_ATPase_H)
SFLDF00027

336K

probable role in phosphate transfer from ATP
336K
SFLD
SFLDF00027 (p-type_atpase)
SFLDG00002

336K

probable role in phosphate transfer from ATP
336K
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)
SFLDF00027

337T

conserved in all p-type atpases
337T, 338G, 339T
SFLD
SFLDF00027 (p-type_atpase)

338G

conserved in all p-type atpases
337T, 338G, 339T
SFLD
SFLDF00027 (p-type_atpase)

339T

conserved in all p-type atpases
337T, 338G, 339T
SFLD
SFLDF00027 (p-type_atpase)
SFLDG00002

337T

conserved in all p-type atpases
337T, 338G, 339T
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)

338G

conserved in all p-type atpases
337T, 338G, 339T
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)

339T

conserved in all p-type atpases
337T, 338G, 339T
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)
SFLDF00027

517T

coordinates with phosphate oxygen from ATP
517T
SFLD
SFLDF00027 (p-type_atpase)
SFLDG00002

517T

coordinates with phosphate oxygen from ATP
517T
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)
SFLDF00027

575K

stabilizes transition state of phosphoryl transfer by contacting beta & gamma phosphate oxygens of ATP
575K
SFLD
SFLDF00027 (p-type_atpase)
SFLDG00002

575K

stabilizes transition state of phosphoryl transfer by contacting beta & gamma phosphate oxygens of ATP
575K
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)
SFLDF00027

594D

Mg2+ ligand
594D, 598D
SFLD
SFLDF00027 (p-type_atpase)

598D

Mg2+ ligand
594D, 598D
SFLD
SFLDF00027 (p-type_atpase)
SFLDG00002

594D

Mg2+ ligand
594D, 598D
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)

598D

Mg2+ ligand
594D, 598D
SFLD
SFLDG00002 (C1.7:_P-type_atpase_like)
proton binding sit...

654Y

proton binding site
654Y, 655A, 659T, 661R, 690D, 771S
CDD
cd02076 (P-type_ATPase_H)

655A

proton binding site
654Y, 655A, 659T, 661R, 690D, 771S
CDD
cd02076 (P-type_ATPase_H)

659T

proton binding site
654Y, 655A, 659T, 661R, 690D, 771S
CDD
cd02076 (P-type_ATPase_H)

661R

proton binding site
654Y, 655A, 659T, 661R, 690D, 771S
CDD
cd02076 (P-type_ATPase_H)

690D

proton binding site
654Y, 655A, 659T, 661R, 690D, 771S
CDD
cd02076 (P-type_ATPase_H)

771S

proton binding site
654Y, 655A, 659T, 661R, 690D, 771S
CDD
cd02076 (P-type_ATPase_H)

GO term prediction

Biological Process

GO:0120029 proton export across plasma membrane

Molecular Function

GO:0000166 nucleotide binding
GO:0008553 proton-exporting ATPase activity, phosphorylative mechanism

Cellular Component

GO:0016021 integral component of membrane

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Entry type

Status

Per-residue features