Mp1g02890.2

Protein

Length

391 amino acids

Protein family membership

E2F Family (IPR015633)

Homologous superfamilies

Homologous superfamily
59 - 133
Winged helix-like DNA-binding domain superfamily (IPR036388)
144 - 246
E2F-DP heterodimerization region (IPR037241)
Homologous superfamily
65 - 128
Winged helix DNA-binding domain superfamily (IPR036390)

1 50 100 150 200 250 300 350 391

Domains and repeats

Domain
65 - 130
E2F/DP family, winged-helix DNA-binding domain (IPR003316)
141 - 246
E2F transcription factor, CC-MB domain (IPR032198)

1 50 100 150 200 250 300 350 391

Detailed signature matches

IPR036388

Winged helix-like DNA-binding domain superfamily
1. G3DSA:1.10.10.10 ("...)
  
  59 - 133
  
  GENE3D
  G3DSA:1.10.10.10 (""winged helix"" repressor DNA binding domain)
IPR036390

Winged helix DNA-binding domain superfamily
1. SSF46785 ("Winged h...)
  
  65 - 128
  
  SUPERFAMILY
  SSF46785 ("Winged helix" DNA-binding domain)
IPR037241

E2F-DP heterodimerization region
1. SSF144074 (E2F-DP h...)
  
  144 - 246
  
  SUPERFAMILY
  SSF144074 (E2F-DP heterodimerization region)
IPR015633

E2F Family
1. PTHR12081 (TRANSCRI...)
  
  2 - 383
  
  PANTHER
  PTHR12081 (TRANSCRIPTION FACTOR E2F)
IPR003316

E2F/DP family, winged-helix DNA-binding domain
1. SM01372 (E2F_TDP_2)
  
  65 - 130
  
  SMART
  SM01372 (E2F_TDP_2)
2. PF02319 (E2F_TDP)
  
  67 - 130
  
  Pfam
  PF02319 (E2F_TDP)
IPR032198

E2F transcription factor, CC-MB domain
1. cd14660 (E2F_DD)
  
  141 - 246
  
  CDD
  cd14660 (E2F_DD)
2. PF16421 (E2F_CC-MB)
  
  146 - 245
  
  Pfam
  PF16421 (E2F_CC-MB)

no IPR

Unintegrated signatures

PTHR12081:SF83 (TRA...)

2 - 383

PANTHER
PTHR12081:SF83 (TRANSCRIPTION FACTOR E2FB)

Other features

Coil

143 - 177

COILS
Coil (Coil)
mobidb-lite (disord...)

1 - 29

MobiDB Lite
mobidb-lite (disorder_prediction)

41 - 62

MobiDB Lite
mobidb-lite (disorder_prediction)

365 - 391

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

heterodimer interf...

142D

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

143A

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

146L

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

147Q

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

149E

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

150I

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

153L

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

154L

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

156A

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

157E

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

160M

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

161D

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

163R

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

164I

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

166E

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

167M

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

168R

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

170R

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

171L

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

174L

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

182Q

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

183W

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

184L

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

185Y

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

186V

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

187T

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

190D

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

191I

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

194L

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

198Q

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

199N

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

200E

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

201T

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

202L

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

203L

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

204A

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

205I

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

206K

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

228R

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

229Y

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

230Q

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

231I

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

232L

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

233L

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

234R

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

235S

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

237M

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

238G

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

239P

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

240I

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)

242V

heterodimer interface
142D, 143A, 146L, 147Q, 149E, 150I, 153L, 154L, 156A, 157E, 160M, 161D, 163R, 164I, 166E, 167M, 168R, 170R, 171L, 174L, 182Q, 183W, 184L, 185Y, 186V, 187T, 190D, 191I, 194L, 198Q, 199N, 200E, 201T, 202L, 203L, 204A, 205I, 206K, 228R, 229Y, 230Q, 231I, 232L, 233L, 234R, 235S, 237M, 238G, 239P, 240I, 242V
CDD
cd14660 (E2F_DD)
RbC binding site c...

208P

RbC binding site
208P, 209H, 210G, 211T, 212T, 213L, 214E, 215V, 216P, 217D, 219D, 220E, 229Y
CDD
cd14660 (E2F_DD)

209H

RbC binding site
208P, 209H, 210G, 211T, 212T, 213L, 214E, 215V, 216P, 217D, 219D, 220E, 229Y
CDD
cd14660 (E2F_DD)

210G

RbC binding site
208P, 209H, 210G, 211T, 212T, 213L, 214E, 215V, 216P, 217D, 219D, 220E, 229Y
CDD
cd14660 (E2F_DD)

211T

RbC binding site
208P, 209H, 210G, 211T, 212T, 213L, 214E, 215V, 216P, 217D, 219D, 220E, 229Y
CDD
cd14660 (E2F_DD)

212T

RbC binding site
208P, 209H, 210G, 211T, 212T, 213L, 214E, 215V, 216P, 217D, 219D, 220E, 229Y
CDD
cd14660 (E2F_DD)

213L

RbC binding site
208P, 209H, 210G, 211T, 212T, 213L, 214E, 215V, 216P, 217D, 219D, 220E, 229Y
CDD
cd14660 (E2F_DD)

214E

RbC binding site
208P, 209H, 210G, 211T, 212T, 213L, 214E, 215V, 216P, 217D, 219D, 220E, 229Y
CDD
cd14660 (E2F_DD)

215V

RbC binding site
208P, 209H, 210G, 211T, 212T, 213L, 214E, 215V, 216P, 217D, 219D, 220E, 229Y
CDD
cd14660 (E2F_DD)

216P

RbC binding site
208P, 209H, 210G, 211T, 212T, 213L, 214E, 215V, 216P, 217D, 219D, 220E, 229Y
CDD
cd14660 (E2F_DD)

217D

RbC binding site
208P, 209H, 210G, 211T, 212T, 213L, 214E, 215V, 216P, 217D, 219D, 220E, 229Y
CDD
cd14660 (E2F_DD)

219D

RbC binding site
208P, 209H, 210G, 211T, 212T, 213L, 214E, 215V, 216P, 217D, 219D, 220E, 229Y
CDD
cd14660 (E2F_DD)

220E

RbC binding site
208P, 209H, 210G, 211T, 212T, 213L, 214E, 215V, 216P, 217D, 219D, 220E, 229Y
CDD
cd14660 (E2F_DD)

229Y

RbC binding site
208P, 209H, 210G, 211T, 212T, 213L, 214E, 215V, 216P, 217D, 219D, 220E, 229Y
CDD
cd14660 (E2F_DD)

GO term prediction

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0046983 protein dimerization activity

Cellular Component

GO:0005667 transcription regulator complex

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Entry type

Status

Per-residue features