Mp7g08500.1

Protein

Length

1,610 amino acids

Protein family membership

3'5'-cyclic nucleotide phosphodiesterase (IPR023088)

Homologous superfamilies

Homologous superfamily
85 - 304
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily (IPR036971)
338 - 472
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily (IPR036971)
1,326 - 1,531
Nucleotide cyclase (IPR029787)

1 200 400 600 800 1000 1200 1400 1610

Domains and repeats

Domain
77 - 465
HD/PDEase domain (IPR003607)
3'5'-cyclic nucleotide phosphodiesterase, catalytic domain (IPR002073)
1,305 - 1,530
Adenylyl cyclase class-3/4/guanylyl cyclase (IPR001054)

1 200 400 600 800 1000 1200 1400 1610

Detailed signature matches

IPR036971

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
1. G3DSA:1.10.13... (C...)
  
  85 - 304
  
  GENE3D
  G3DSA:1.10.1300.10 (Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b)
  
  338 - 472
  
  GENE3D
  G3DSA:1.10.1300.10 (Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b)
IPR029787

Nucleotide cyclase
1. G3DSA:3.30.70... (A...)
  
  1,329 - 1,531
  
  GENE3D
  G3DSA:3.30.70.1230 (Adenylyl Cyclase)
2. SSF55073 (Nucleotid...)
  
  1,326 - 1,531
  
  SUPERFAMILY
  SSF55073 (Nucleotide cyclase)
IPR023088

3'5'-cyclic nucleotide phosphodiesterase
1. PR00387 (PDIESTERASE1)
  
  154 - 167
  
  PRINTS
  PR00387 (PDIESTERASE1)
  
  185 - 198
  
  PRINTS
  PR00387 (PDIESTERASE1)
  
  199 - 214
  
  PRINTS
  PR00387 (PDIESTERASE1)
  
  226 - 242
  
  PRINTS
  PR00387 (PDIESTERASE1)
IPR003607

HD/PDEase domain
1. cd00077 (HDc)
  
  158 - 289
  
  CDD
  cd00077 (HDc)
2. SM00471 (hd_13)
  
  156 - 383
  
  SMART
  SM00471 (hd_13)
IPR002073

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
1. PF00233 (PDEase_I)
  
  158 - 445
  
  Pfam
  PF00233 (PDEase_I)
2. PS51845 (PDEASE_I_2)
  
  77 - 465
  
  PROSITE profiles
  PS51845 (PDEASE_I_2)
IPR001054

Adenylyl cyclase class-3/4/guanylyl cyclase
1. cd07302 (CHD)
  
  1,333 - 1,529
  
  CDD
  cd07302 (CHD)
2. PS50125 (GUANYLATE_...)
  
  1,335 - 1,482
  
  PROSITE profiles
  PS50125 (GUANYLATE_CYCLASE_2)
3. PF00211 (Guanylate_cyc)
  
  1,335 - 1,530
  
  Pfam
  PF00211 (Guanylate_cyc)
4. SM00044 (cyc_6)
  
  1,305 - 1,523
  
  SMART
  SM00044 (cyc_6)
IPR023174

3'5'-cyclic nucleotide phosphodiesterase, conserved site
1. PS00126 (PDEASE_I_1)
  
  199 - 210
  
  PROSITE patterns
  PS00126 (PDEASE_I_1)

no IPR

Unintegrated signatures

PTHR43336 (OXYGEN S...)

863 - 1,610

PANTHER
PTHR43336 (OXYGEN SENSOR HISTIDINE KINASE RESPONSE REGULATOR DEVS/DOSS)

253 - 599

PANTHER
PTHR43336 (OXYGEN SENSOR HISTIDINE KINASE RESPONSE REGULATOR DEVS/DOSS)
PTHR43336:SF3 (PHOS...)

253 - 599

PANTHER
PTHR43336:SF3 (PHOSPHODIESTERASE)

863 - 1,610

PANTHER
PTHR43336:SF3 (PHOSPHODIESTERASE)
SSF109604 (HD-domai...)

341 - 463

SUPERFAMILY
SSF109604 (HD-domain/PDEase-like)

95 - 286

SUPERFAMILY
SSF109604 (HD-domain/PDEase-like)

Other features

Coil

3 - 23

COILS
Coil (Coil)
mobidb-lite (disord...)

516 - 644

MobiDB Lite
mobidb-lite (disorder_prediction)

706 - 725

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 30

MobiDB Lite
mobidb-lite (disorder_prediction)

779 - 798

MobiDB Lite
mobidb-lite (disorder_prediction)

315 - 335

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Polar)

516 - 539

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

546 - 607

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

619 - 633

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

Residue annotation

Mg2+ binding site ...

200D

Mg2+ binding site
200D
CDD
cd00077 (HDc)
nucleotidyl bindin...

1,338F

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,340D

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,341I

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,342R

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,343N

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,344F

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,345T

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,379K

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,381I

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,382G

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,383D

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,386L

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,469S

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,470Y

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,471L

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,475V

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,476N

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,479S

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,480R

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)

1,520K

nucleotidyl binding site
1,338F, 1,340D, 1,341I, 1,342R, 1,343N, 1,344F, 1,345T, 1,379K, 1,381I, 1,382G, 1,383D, 1,386L, 1,469S, 1,470Y, 1,471L, 1,475V, 1,476N, 1,479S, 1,480R, 1,520K
CDD
cd07302 (CHD)
metal binding site...

1,340D

metal binding site
1,340D, 1,383D
CDD
cd07302 (CHD)

1,383D

metal binding site
1,340D, 1,383D
CDD
cd07302 (CHD)
dimer interface cd...

1,345T

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,356M

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,359V

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,360N

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,363A

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,367H

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,379K

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,380N

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,456I

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,459A

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,470Y

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,471L

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,472S

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,473P

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,476N

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

1,520K

dimer interface
1,345T, 1,356M, 1,359V, 1,360N, 1,363A, 1,367H, 1,379K, 1,380N, 1,456I, 1,459A, 1,470Y, 1,471L, 1,472S, 1,473P, 1,476N, 1,520K
CDD
cd07302 (CHD)

GO term prediction

Biological Process

GO:0007165 signal transduction
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

Molecular Function

GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features