Mp1g02840.1

Protein

Length

1,748 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
169 - 634
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
695 - 794
Dicer dimerisation domain superfamily (IPR038248)
1,051 - 1,166
PAZ domain superfamily (IPR036085)
1,201 - 1,384
Ribonuclease III, endonuclease domain superfamily (IPR036389)
1,405 - 1,581
Ribonuclease III, endonuclease domain superfamily (IPR036389)

1 200 400 600 800 1000 1200 1400 1600 1748

Domains and repeats

Domain
154 - 351
Helicase superfamily 1/2, ATP-binding domain (IPR014001)
Helicase/UvrB, N-terminal (IPR006935)
514 - 676
Helicase, C-terminal (IPR001650)
700 - 791
Dicer dimerisation domain (IPR005034)
1,021 - 1,190
PAZ domain (IPR003100)
1,191 - 1,389
Ribonuclease III domain (IPR000999)
1,410 - 1,582
Ribonuclease III domain (IPR000999)
1,585 - 1,651
Double-stranded RNA-binding domain (IPR014720)

1 200 400 600 800 1000 1200 1400 1600 1748

Detailed signature matches

IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  494 - 634
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  169 - 326
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR038248

Dicer dimerisation domain superfamily
1. G3DSA:3.30.16...
  
  695 - 794
  
  GENE3D
  G3DSA:3.30.160.380 (G3DSA:3.30.160.380)
IPR036085

PAZ domain superfamily
1. SSF101690 (PAZ domain)
  
  1,051 - 1,123
  
  SUPERFAMILY
  SSF101690 (PAZ domain)
  
  1,154 - 1,166
  
  SUPERFAMILY
  SSF101690 (PAZ domain)
IPR036389

Ribonuclease III, endonuclease domain superfamily
1. G3DSA:1.10.15...
  
  1,405 - 1,581
  
  GENE3D
  G3DSA:1.10.1520.10 (G3DSA:1.10.1520.10)
2. SSF69065 (RNase III...)
  
  1,201 - 1,285
  
  SUPERFAMILY
  SSF69065 (RNase III domain-like)
  
  1,343 - 1,384
  
  SUPERFAMILY
  SSF69065 (RNase III domain-like)
  
  1,409 - 1,509
  
  SUPERFAMILY
  SSF69065 (RNase III domain-like)
  
  1,539 - 1,580
  
  SUPERFAMILY
  SSF69065 (RNase III domain-like)
IPR014001

Helicase superfamily 1/2, ATP-binding domain
1. PS51192 (HELICASE_A...)
  
  165 - 323
  
  PROSITE profiles
  PS51192 (HELICASE_ATP_BIND_1)
2. SM00487 (ultradead3)
  
  154 - 351
  
  SMART
  SM00487 (ultradead3)
IPR006935

Helicase/UvrB, N-terminal
1. PF04851 (ResIII)
  
  167 - 323
  
  Pfam
  PF04851 (ResIII)
IPR001650

Helicase, C-terminal
1. PS51194 (HELICASE_CTER)
  
  514 - 676
  
  PROSITE profiles
  PS51194 (HELICASE_CTER)
2. SM00490 (helicmild6)
  
  559 - 632
  
  SMART
  SM00490 (helicmild6)
3. PF00271 (Helicase_C)
  
  518 - 631
  
  Pfam
  PF00271 (Helicase_C)
IPR005034

Dicer dimerisation domain
1. PS51327 (DICER_DSRBF)
  
  700 - 791
  
  PROSITE profiles
  PS51327 (DICER_DSRBF)
IPR003100

PAZ domain
1. PS50821 (PAZ)
  
  1,052 - 1,166
  
  PROSITE profiles
  PS50821 (PAZ)
2. PF02170 (PAZ)
  
  1,051 - 1,186
  
  Pfam
  PF02170 (PAZ)
3. SM00949 (PAZ_2_a_3)
  
  1,021 - 1,190
  
  SMART
  SM00949 (PAZ_2_a_3)
IPR000999

Ribonuclease III domain
1. PF00636 (Ribonuclea...)
  
  1,228 - 1,368
  
  Pfam
  PF00636 (Ribonuclease_3)
  
  1,446 - 1,559
  
  Pfam
  PF00636 (Ribonuclease_3)
2. cd00593 (RIBOc)
  
  1,426 - 1,582
  
  CDD
  cd00593 (RIBOc)
  
  1,212 - 1,379
  
  CDD
  cd00593 (RIBOc)
3. PS00517 (RNASE_3_1)
  
  1,446 - 1,454
  
  PROSITE patterns
  PS00517 (RNASE_3_1)
4. SM00535 (riboneu5)
  
  1,210 - 1,389
  
  SMART
  SM00535 (riboneu5)
  
  1,425 - 1,582
  
  SMART
  SM00535 (riboneu5)
5. PS50142 (RNASE_3_2)
  
  1,191 - 1,369
  
  PROSITE profiles
  PS50142 (RNASE_3_2)
  
  1,410 - 1,559
  
  PROSITE profiles
  PS50142 (RNASE_3_2)
IPR014720

Double-stranded RNA-binding domain
1. PS50137 (DS_RBD)
  
  1,585 - 1,651
  
  PROSITE profiles
  PS50137 (DS_RBD)
2. SM00358 (DRBM_3)
  
  1,586 - 1,650
  
  SMART
  SM00358 (DRBM_3)

no IPR

Unintegrated signatures

G3DSA:1.20.13...

378 - 508

GENE3D
G3DSA:1.20.1320.30 (G3DSA:1.20.1320.30)
G3DSA:2.170.2... (p...)

1,042 - 1,169

GENE3D
G3DSA:2.170.260.10 (paz domain)
G3DSA:3.30.16...

1,582 - 1,653

GENE3D
G3DSA:3.30.160.20 (G3DSA:3.30.160.20)
G3DSA:3.40.50...

159 - 364

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

509 - 654

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)

365 - 377

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
PF03368 (Dicer_dimer)

700 - 785

Pfam
PF03368 (Dicer_dimer)
PTHR14950 (DICER-RE...)

152 - 1,684

PANTHER
PTHR14950 (DICER-RELATED)
PTHR14950:SF46 (END...)

152 - 1,684

PANTHER
PTHR14950:SF46 (ENDORIBONUCLEASE DICER HOMOLOG 3)
SSF54768 (dsRNA-bin...)

1,541 - 1,651

SUPERFAMILY
SSF54768 (dsRNA-binding domain-like)
cd18034 (DEXHc_dicer)

157 - 355

CDD
cd18034 (DEXHc_dicer)

Other features

Coil

1,632 - 1,652

COILS
Coil (Coil)
mobidb-lite (disord...)

1,119 - 1,149

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Polar)

1,124 - 1,140

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

Residue annotation

ATP binding site c...

157K

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

158A

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

159R

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

162Q

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

179E

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

180T

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

181G

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

182C

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

183G

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

184K

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

185T

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

186L

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

225I

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

288E

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)

321A

ATP binding site
157K, 158A, 159R, 162Q, 179E, 180T, 181G, 182C, 183G, 184K, 185T, 186L, 225I, 288E, 321A
CDD
cd18034 (DEXHc_dicer)
nucleic acid bindi...

213P

nucleic acid binding site
213P, 214T, 237F, 238G, 263T, 265Q, 266I, 269D, 294K, 295K, 296H
CDD
cd18034 (DEXHc_dicer)

214T

nucleic acid binding site
213P, 214T, 237F, 238G, 263T, 265Q, 266I, 269D, 294K, 295K, 296H
CDD
cd18034 (DEXHc_dicer)

237F

nucleic acid binding site
213P, 214T, 237F, 238G, 263T, 265Q, 266I, 269D, 294K, 295K, 296H
CDD
cd18034 (DEXHc_dicer)

238G

nucleic acid binding site
213P, 214T, 237F, 238G, 263T, 265Q, 266I, 269D, 294K, 295K, 296H
CDD
cd18034 (DEXHc_dicer)

263T

nucleic acid binding site
213P, 214T, 237F, 238G, 263T, 265Q, 266I, 269D, 294K, 295K, 296H
CDD
cd18034 (DEXHc_dicer)

265Q

nucleic acid binding site
213P, 214T, 237F, 238G, 263T, 265Q, 266I, 269D, 294K, 295K, 296H
CDD
cd18034 (DEXHc_dicer)

266I

nucleic acid binding site
213P, 214T, 237F, 238G, 263T, 265Q, 266I, 269D, 294K, 295K, 296H
CDD
cd18034 (DEXHc_dicer)

269D

nucleic acid binding site
213P, 214T, 237F, 238G, 263T, 265Q, 266I, 269D, 294K, 295K, 296H
CDD
cd18034 (DEXHc_dicer)

294K

nucleic acid binding site
213P, 214T, 237F, 238G, 263T, 265Q, 266I, 269D, 294K, 295K, 296H
CDD
cd18034 (DEXHc_dicer)

295K

nucleic acid binding site
213P, 214T, 237F, 238G, 263T, 265Q, 266I, 269D, 294K, 295K, 296H
CDD
cd18034 (DEXHc_dicer)

296H

nucleic acid binding site
213P, 214T, 237F, 238G, 263T, 265Q, 266I, 269D, 294K, 295K, 296H
CDD
cd18034 (DEXHc_dicer)
DEAD box helicase ...

287D

DEAD box helicase motif
287D, 288E, 289C, 290H
CDD
cd18034 (DEXHc_dicer)

288E

DEAD box helicase motif
287D, 288E, 289C, 290H
CDD
cd18034 (DEXHc_dicer)

289C

DEAD box helicase motif
287D, 288E, 289C, 290H
CDD
cd18034 (DEXHc_dicer)

290H

DEAD box helicase motif
287D, 288E, 289C, 290H
CDD
cd18034 (DEXHc_dicer)
dimerization inter...

1,228E

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,229G

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,232L

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,233L

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,236S

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,239K

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,240Y

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,243S

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,244K

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,246L

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,247F

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,248L

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,258L

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,365L

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)

1,374L

dimerization interface
1,228E, 1,229G, 1,232L, 1,233L, 1,236S, 1,239K, 1,240Y, 1,243S, 1,244K, 1,246L, 1,247F, 1,248L, 1,258L, 1,365L, 1,374L
CDD
cd00593 (RIBOc)
active site cd00593

1,446Q

active site
1,446Q, 1,449E, 1,453D, 1,545D, 1,548E
CDD
cd00593 (RIBOc)

1,449E

active site
1,446Q, 1,449E, 1,453D, 1,545D, 1,548E
CDD
cd00593 (RIBOc)

1,453D

active site
1,446Q, 1,449E, 1,453D, 1,545D, 1,548E
CDD
cd00593 (RIBOc)

1,545D

active site
1,446Q, 1,449E, 1,453D, 1,545D, 1,548E
CDD
cd00593 (RIBOc)

1,548E

active site
1,446Q, 1,449E, 1,453D, 1,545D, 1,548E
CDD
cd00593 (RIBOc)
active site cd00593

1,228E

active site
1,228E, 1,231E, 1,235D, 1,355D, 1,358E
CDD
cd00593 (RIBOc)

1,231E

active site
1,228E, 1,231E, 1,235D, 1,355D, 1,358E
CDD
cd00593 (RIBOc)

1,235D

active site
1,228E, 1,231E, 1,235D, 1,355D, 1,358E
CDD
cd00593 (RIBOc)

1,355D

active site
1,228E, 1,231E, 1,235D, 1,355D, 1,358E
CDD
cd00593 (RIBOc)

1,358E

active site
1,228E, 1,231E, 1,235D, 1,355D, 1,358E
CDD
cd00593 (RIBOc)
dimerization inter...

1,446Q

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,447R

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,450F

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,451L

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,454A

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,457D

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,458Y

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,461T

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,462R

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,464L

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,465Y

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,466F

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,476L

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,555L

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)

1,566W

dimerization interface
1,446Q, 1,447R, 1,450F, 1,451L, 1,454A, 1,457D, 1,458Y, 1,461T, 1,462R, 1,464L, 1,465Y, 1,466F, 1,476L, 1,555L, 1,566W
CDD
cd00593 (RIBOc)
metal binding site...

1,449E

metal binding site
1,449E, 1,545D, 1,548E
CDD
cd00593 (RIBOc)

1,545D

metal binding site
1,449E, 1,545D, 1,548E
CDD
cd00593 (RIBOc)

1,548E

metal binding site
1,449E, 1,545D, 1,548E
CDD
cd00593 (RIBOc)
metal binding site...

1,231E

metal binding site
1,231E, 1,355D, 1,358E
CDD
cd00593 (RIBOc)

1,355D

metal binding site
1,231E, 1,355D, 1,358E
CDD
cd00593 (RIBOc)

1,358E

metal binding site
1,231E, 1,355D, 1,358E
CDD
cd00593 (RIBOc)

GO term prediction

Biological Process

GO:0006396 RNA processing

Molecular Function

GO:0003677 DNA binding
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters

Cellular Component