Mp1g20630.1

Protein

Length

758 amino acids

Protein family membership

Squalene cyclase (IPR018333)

Homologous superfamilies

Homologous superfamily
121 - 756
Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (IPR008930)

1 100 200 300 400 500 600 700 758

Domains and repeats

Domain
100 - 403
Squalene cyclase, N-terminal (IPR032697)
415 - 753
Squalene cyclase, C-terminal (IPR032696)

1 100 200 300 400 500 600 700 758

Detailed signature matches

IPR008930

Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
1. SSF48239 (Terpenoid...)
  
  121 - 409
  
  SUPERFAMILY
  SSF48239 (Terpenoid cyclases/Protein prenyltransferases)
  
  341 - 756
  
  SUPERFAMILY
  SSF48239 (Terpenoid cyclases/Protein prenyltransferases)
IPR018333

Squalene cyclase
1. TIGR01787
  
  97 - 753
  
  TIGRFAMs
  TIGR01787 (TIGR01787)
2. SFLDG01016 (Prenylt...)
  
  25 - 754
  
  SFLD
  SFLDG01016 (Prenyltransferase_Like_2)
3. cd02892 (SQCY_1)
  
  98 - 751
  
  CDD
  cd02892 (SQCY_1)
IPR032697

Squalene cyclase, N-terminal
1. PF13249 (SQHop_cycl...)
  
  100 - 403
  
  Pfam
  PF13249 (SQHop_cyclase_N)
IPR032696

Squalene cyclase, C-terminal
1. PF13243 (SQHop_cycl...)
  
  415 - 753
  
  Pfam
  PF13243 (SQHop_cyclase_C)
IPR002365

Terpene synthase, conserved site
1. PS01074 (TERPENE_SY...)
  
  605 - 619
  
  PROSITE patterns
  PS01074 (TERPENE_SYNTHASES)

no IPR

Unintegrated signatures

G3DSA:1.50.10.20

119 - 413

GENE3D
G3DSA:1.50.10.20 (G3DSA:1.50.10.20)

414 - 751

GENE3D
G3DSA:1.50.10.20 (G3DSA:1.50.10.20)

108 - 118

GENE3D
G3DSA:1.50.10.20 (G3DSA:1.50.10.20)
PTHR11764 (TERPENE ...)

1 - 757

PANTHER
PTHR11764 (TERPENE CYCLASE/MUTASE FAMILY MEMBER)
PTHR11764:SF27 (TER...)

1 - 757

PANTHER
PTHR11764:SF27 (TERPENE CYCLASE/MUTASE FAMILY MEMBER)

Residue annotation

Active site cavity...

119Y

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

124F

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

125L

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

128G

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

180L

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

217P

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

219W

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

223W

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

259H

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

260C

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

263V

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

369P

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

370V

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

374L

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

412Y

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

413N

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

418W

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

474F

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

483I

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

485D

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

486C

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

534Y

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

549S

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

550E

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

552F

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

556M

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

567A

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

612W

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

618Y

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

729N

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

732C

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

734I

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

736Y

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)

739Y

Active site cavity
119Y, 124F, 125L, 128G, 180L, 217P, 219W, 223W, 259H, 260C, 263V, 369P, 370V, 374L, 412Y, 413N, 418W, 474F, 483I, 485D, 486C, 534Y, 549S, 550E, 552F, 556M, 567A, 612W, 618Y, 729N, 732C, 734I, 736Y, 739Y
CDD
cd02892 (SQCY_1)
SFLDG01016

418W

stabilizes intermediate
418W, 474F
SFLD
SFLDG01016 (Prenyltransferase_Like_2)

474F

stabilizes intermediate
418W, 474F
SFLD
SFLDG01016 (Prenyltransferase_Like_2)
catalytic acid cd0...

485D

catalytic acid
485D
CDD
cd02892 (SQCY_1)
SFLDG01016

485D

initiates catalyzed reaction via protonation of substrate
485D
SFLD
SFLDG01016 (Prenyltransferase_Like_2)
SFLDG01016

612W

stabilizes intermediate
612W
SFLD
SFLDG01016 (Prenyltransferase_Like_2)

GO term prediction

Biological Process

GO:0016104 triterpenoid biosynthetic process

Molecular Function

GO:0000250 lanosterol synthase activity
GO:0016866 intramolecular transferase activity
GO:0042300 beta-amyrin synthase activity

Cellular Component

GO:0005811 lipid droplet

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Entry type

Status

Per-residue features