Mp1g21170.1

Protein

Length

2,057 amino acids

Protein family membership

Phosphatidylinositol kinase (IPR015433)

Homologous superfamilies

Homologous superfamily
135 - 992
Armadillo-type fold (IPR016024)
1,496 - 1,667
Armadillo-type fold (IPR016024)
1,849 - 2,055
Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily (IPR036940)
Homologous superfamily
1,486 - 1,674
Phosphoinositide 3-kinase, accessory (PIK) domain superfamily (IPR042236)
1,708 - 2,050
Protein kinase-like domain superfamily (IPR011009)

1 200 400 600 800 1000 1200 1400 1600 1800 2057

Domains and repeats

Domain
1,509 - 1,694
Phosphoinositide 3-kinase, accessory (PIK) domain (IPR001263)
1,796 - 2,054
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)

1 200 400 600 800 1000 1200 1400 1600 1800 2057

Detailed signature matches

IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  880 - 992
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  640 - 722
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  135 - 188
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  329 - 383
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  426 - 480
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  514 - 608
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
  
  1,496 - 1,667
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR042236

Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
1. G3DSA:1.25.40.70
  
  1,486 - 1,674
  
  GENE3D
  G3DSA:1.25.40.70 (G3DSA:1.25.40.70)
IPR011009

Protein kinase-like domain superfamily
1. SSF56112 (Protein k...)
  
  1,708 - 2,050
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR036940

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
1. G3DSA:1.10.10...
  
  1,849 - 2,055
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
IPR015433

Phosphatidylinositol kinase
1. PTHR10048 (PHOSPHAT...)
  
  9 - 2,056
  
  PANTHER
  PTHR10048 (PHOSPHATIDYLINOSITOL KINASE)
IPR001263

Phosphoinositide 3-kinase, accessory (PIK) domain
1. PF00613 (PI3Ka)
  
  1,556 - 1,672
  
  Pfam
  PF00613 (PI3Ka)
2. SM00145 (pi3k_hr2_4)
  
  1,509 - 1,694
  
  SMART
  SM00145 (pi3k_hr2_4)
3. PS51545 (PIK_HELICAL)
  
  1,510 - 1,682
  
  PROSITE profiles
  PS51545 (PIK_HELICAL)
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. PS50290 (PI3_4_KINA...)
  
  1,796 - 2,038
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
2. SM00146 (pi3k_hr1_6)
  
  1,797 - 2,054
  
  SMART
  SM00146 (pi3k_hr1_6)
3. PF00454 (PI3_PI4_ki...)
  
  1,797 - 2,004
  
  Pfam
  PF00454 (PI3_PI4_kinase)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00915 (PI3_4_KINA...)
  
  1,800 - 1,814
  
  PROSITE patterns
  PS00915 (PI3_4_KINASE_1)

no IPR

Unintegrated signatures

G3DSA:3.30.10...

1,702 - 1,848

GENE3D
G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
PTHR10048:SF110 (BN...)

9 - 2,056

PANTHER
PTHR10048:SF110 (BNAA06G03180D PROTEIN)
cd05167 (PI4Kc_III_...)

1,758 - 2,056

CDD
cd05167 (PI4Kc_III_alpha)

Other features

mobidb-lite (disord...)

195 - 236

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

1,769L

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,771S

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,772A

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,774K

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,776P

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,799I

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,801K

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,804D

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,835Y

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,847I

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,848E

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,849V

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,850V

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,855S

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,858Q

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,913N

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,915L

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,925I

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)

1,926D

ATP binding site
1,769L, 1,771S, 1,772A, 1,774K, 1,776P, 1,799I, 1,801K, 1,804D, 1,835Y, 1,847I, 1,848E, 1,849V, 1,850V, 1,855S, 1,858Q, 1,913N, 1,915L, 1,925I, 1,926D
CDD
cd05167 (PI4Kc_III_alpha)
catalytic loop cd0...

1,905Q

catalytic loop
1,905Q, 1,906P, 1,907K, 1,908D, 1,909R, 1,910H, 1,911N, 1,912G, 1,913N
CDD
cd05167 (PI4Kc_III_alpha)

1,906P

catalytic loop
1,905Q, 1,906P, 1,907K, 1,908D, 1,909R, 1,910H, 1,911N, 1,912G, 1,913N
CDD
cd05167 (PI4Kc_III_alpha)

1,907K

catalytic loop
1,905Q, 1,906P, 1,907K, 1,908D, 1,909R, 1,910H, 1,911N, 1,912G, 1,913N
CDD
cd05167 (PI4Kc_III_alpha)

1,908D

catalytic loop
1,905Q, 1,906P, 1,907K, 1,908D, 1,909R, 1,910H, 1,911N, 1,912G, 1,913N
CDD
cd05167 (PI4Kc_III_alpha)

1,909R

catalytic loop
1,905Q, 1,906P, 1,907K, 1,908D, 1,909R, 1,910H, 1,911N, 1,912G, 1,913N
CDD
cd05167 (PI4Kc_III_alpha)

1,910H

catalytic loop
1,905Q, 1,906P, 1,907K, 1,908D, 1,909R, 1,910H, 1,911N, 1,912G, 1,913N
CDD
cd05167 (PI4Kc_III_alpha)

1,911N

catalytic loop
1,905Q, 1,906P, 1,907K, 1,908D, 1,909R, 1,910H, 1,911N, 1,912G, 1,913N
CDD
cd05167 (PI4Kc_III_alpha)

1,912G

catalytic loop
1,905Q, 1,906P, 1,907K, 1,908D, 1,909R, 1,910H, 1,911N, 1,912G, 1,913N
CDD
cd05167 (PI4Kc_III_alpha)

1,913N

catalytic loop
1,905Q, 1,906P, 1,907K, 1,908D, 1,909R, 1,910H, 1,911N, 1,912G, 1,913N
CDD
cd05167 (PI4Kc_III_alpha)
activation loop (A...

1,926D

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,927F

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,928G

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,929F

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,930I

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,931L

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,932E

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,933T

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,934S

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,935P

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,936G

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,939M

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,940R

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,941F

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,942E

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,944A

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,945H

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,946F

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,947K

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,948L

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

1,949S

activation loop (A-loop)
1,926D, 1,927F, 1,928G, 1,929F, 1,930I, 1,931L, 1,932E, 1,933T, 1,934S, 1,935P, 1,936G, 1,939M, 1,940R, 1,941F, 1,942E, 1,944A, 1,945H, 1,946F, 1,947K, 1,948L, 1,949S
CDD
cd05167 (PI4Kc_III_alpha)

GO term prediction

Biological Process

GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling

Molecular Function

GO:0016301 kinase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features