Mp4g02650.2

Protein

Length

1,497 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
1,020 - 1,151
Zinc finger, RING/FYVE/PHD-type (IPR013083)

1 200 400 600 800 1000 1200 1497

Domains and repeats

Domain
1,016 - 1,149
Extended PHD (ePHD) domain (IPR034732)
1,194 - 1,323
Pre-SET domain (IPR007728)
1,331 - 1,463
SET domain (IPR001214)
1,472 - 1,488
Post-SET domain (IPR003616)

1 200 400 600 800 1000 1200 1497

Detailed signature matches

IPR013083

Zinc finger, RING/FYVE/PHD-type
1. G3DSA:3.30.40.10 (Z...)
  
  1,020 - 1,151
  
  GENE3D
  G3DSA:3.30.40.10 (Zinc/RING finger domain)
IPR034732

Extended PHD (ePHD) domain
1. PS51805 (EPHD)
  
  1,016 - 1,149
  
  PROSITE profiles
  PS51805 (EPHD)
IPR007728

Pre-SET domain
1. PF05033 (Pre-SET)
  
  1,194 - 1,323
  
  Pfam
  PF05033 (Pre-SET)
IPR001214

SET domain
1. PF00856 (SET)
  
  1,342 - 1,457
  
  Pfam
  PF00856 (SET)
2. PS50280 (SET)
  
  1,331 - 1,457
  
  PROSITE profiles
  PS50280 (SET)
3. SM00317 (set_7)
  
  1,331 - 1,463
  
  SMART
  SM00317 (set_7)
IPR003616

Post-SET domain
1. PS50868 (POST_SET)
  
  1,472 - 1,488
  
  PROSITE profiles
  PS50868 (POST_SET)

no IPR

Unintegrated signatures

G3DSA:2.170.2... (S...)

1,187 - 1,487

GENE3D
G3DSA:2.170.270.10 (SET domain)
PF13771 (zf-HC5HC2H)

1,059 - 1,149

Pfam
PF13771 (zf-HC5HC2H)
PTHR46223 (HISTONE-...)

1,288 - 1,487

PANTHER
PTHR46223 (HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H)
PTHR46223:SF3 (HIST...)

1,288 - 1,487

PANTHER
PTHR46223:SF3 (HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED)
SSF82199 (SET domain)

1,179 - 1,259

SUPERFAMILY
SSF82199 (SET domain)

1,286 - 1,458

SUPERFAMILY
SSF82199 (SET domain)
cd10538 (SET_SETDB-...)

1,288 - 1,457

CDD
cd10538 (SET_SETDB-like)
cd15571 (ePHD)

1,051 - 1,148

CDD
cd15571 (ePHD)

Other features

mobidb-lite (disord...)

574 - 595

MobiDB Lite
mobidb-lite (disorder_prediction)

250 - 280

MobiDB Lite
mobidb-lite (disorder_prediction)

169 - 200

MobiDB Lite
mobidb-lite (disorder_prediction)

728 - 747

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 119

MobiDB Lite
mobidb-lite (disorder_prediction)

611 - 645

MobiDB Lite
mobidb-lite (disorder_prediction)

758 - 777

MobiDB Lite
mobidb-lite (disorder_prediction)

905 - 980

MobiDB Lite
mobidb-lite (disorder_prediction)

861 - 889

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Polyam...)

169 - 186

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

871 - 888

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

942 - 969

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

41 - 73

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

91 - 110

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte
mobidb-lite (Polar)

758 - 775

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

627 - 645

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

579 - 595

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar
mobidb-lite (Positi...)

74 - 90

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Positive Polyelectrolyte

Residue annotation

putative histone H...

1,095V

putative histone H3 binding site
1,095V, 1,106A, 1,107T, 1,108L, 1,109G, 1,110C, 1,116R, 1,144A
CDD
cd15571 (ePHD)

1,106A

putative histone H3 binding site
1,095V, 1,106A, 1,107T, 1,108L, 1,109G, 1,110C, 1,116R, 1,144A
CDD
cd15571 (ePHD)

1,107T

putative histone H3 binding site
1,095V, 1,106A, 1,107T, 1,108L, 1,109G, 1,110C, 1,116R, 1,144A
CDD
cd15571 (ePHD)

1,108L

putative histone H3 binding site
1,095V, 1,106A, 1,107T, 1,108L, 1,109G, 1,110C, 1,116R, 1,144A
CDD
cd15571 (ePHD)

1,109G

putative histone H3 binding site
1,095V, 1,106A, 1,107T, 1,108L, 1,109G, 1,110C, 1,116R, 1,144A
CDD
cd15571 (ePHD)

1,110C

putative histone H3 binding site
1,095V, 1,106A, 1,107T, 1,108L, 1,109G, 1,110C, 1,116R, 1,144A
CDD
cd15571 (ePHD)

1,116R

putative histone H3 binding site
1,095V, 1,106A, 1,107T, 1,108L, 1,109G, 1,110C, 1,116R, 1,144A
CDD
cd15571 (ePHD)

1,144A

putative histone H3 binding site
1,095V, 1,106A, 1,107T, 1,108L, 1,109G, 1,110C, 1,116R, 1,144A
CDD
cd15571 (ePHD)
active site cd10538

1,341R

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,342G

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,343W

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,360Y

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,367Q

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,370A

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,371D

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,373R

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,383S

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,384Y

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,385L

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,386F

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,387N

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,411R

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,412F

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,413I

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,414N

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,415H

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,423I

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,425R

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,438I

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,454Y

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,456Y

active site
1,341R, 1,342G, 1,343W, 1,360Y, 1,367Q, 1,370A, 1,371D, 1,373R, 1,383S, 1,384Y, 1,385L, 1,386F, 1,387N, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,423I, 1,425R, 1,438I, 1,454Y, 1,456Y
CDD
cd10538 (SET_SETDB-like)
SAM binding site c...

1,341R

SAM binding site
1,341R, 1,342G, 1,343W, 1,383S, 1,384Y, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,342G

SAM binding site
1,341R, 1,342G, 1,343W, 1,383S, 1,384Y, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,343W

SAM binding site
1,341R, 1,342G, 1,343W, 1,383S, 1,384Y, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,383S

SAM binding site
1,341R, 1,342G, 1,343W, 1,383S, 1,384Y, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,384Y

SAM binding site
1,341R, 1,342G, 1,343W, 1,383S, 1,384Y, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,411R

SAM binding site
1,341R, 1,342G, 1,343W, 1,383S, 1,384Y, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,412F

SAM binding site
1,341R, 1,342G, 1,343W, 1,383S, 1,384Y, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,413I

SAM binding site
1,341R, 1,342G, 1,343W, 1,383S, 1,384Y, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,414N

SAM binding site
1,341R, 1,342G, 1,343W, 1,383S, 1,384Y, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,415H

SAM binding site
1,341R, 1,342G, 1,343W, 1,383S, 1,384Y, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,456Y

SAM binding site
1,341R, 1,342G, 1,343W, 1,383S, 1,384Y, 1,411R, 1,412F, 1,413I, 1,414N, 1,415H, 1,456Y
CDD
cd10538 (SET_SETDB-like)
polypeptide substr...

1,385L

polypeptide substrate binding site
1,385L, 1,386F, 1,387N, 1,423I, 1,438I, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,386F

polypeptide substrate binding site
1,385L, 1,386F, 1,387N, 1,423I, 1,438I, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,387N

polypeptide substrate binding site
1,385L, 1,386F, 1,387N, 1,423I, 1,438I, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,423I

polypeptide substrate binding site
1,385L, 1,386F, 1,387N, 1,423I, 1,438I, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,438I

polypeptide substrate binding site
1,385L, 1,386F, 1,387N, 1,423I, 1,438I, 1,456Y
CDD
cd10538 (SET_SETDB-like)

1,456Y

polypeptide substrate binding site
1,385L, 1,386F, 1,387N, 1,423I, 1,438I, 1,456Y
CDD
cd10538 (SET_SETDB-like)
Zn binding site cd...

1,417C

Zn binding site
1,417C
CDD
cd10538 (SET_SETDB-like)

GO term prediction

Biological Process

GO:0034968 histone lysine methylation

Molecular Function

GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0018024 histone-lysine N-methyltransferase activity

Cellular Component

GO:0005634 nucleus

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Entry type

Status

Per-residue features