Mp6g02720.1

Protein

Length

683 amino acids

Protein family membership

dTDP-glucose 4,6-dehydratase (IPR005888)

Homologous superfamilies

Homologous superfamily
8 - 337
NAD(P)-binding domain superfamily (IPR036291)
394 - 670
NAD(P)-binding domain superfamily (IPR036291)

1 100 200 300 400 500 600 683

Domains and repeats

Domain
15 - 320
NAD(P)-binding domain (IPR016040)
396 - 568
RmlD-like substrate binding domain (IPR029903)

1 100 200 300 400 500 600 683

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  394 - 670
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
  
  8 - 337
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR005888

dTDP-glucose 4,6-dehydratase
1. cd05246 (dTDP_GD_SDR_e)
  
  12 - 329
  
  CDD
  cd05246 (dTDP_GD_SDR_e)
IPR016040

NAD(P)-binding domain
1. PF16363 (GDP_Man_Dehyd)
  
  15 - 320
  
  Pfam
  PF16363 (GDP_Man_Dehyd)
IPR029903

RmlD-like substrate binding domain
1. PF04321 (RmlD_sub_bind)
  
  396 - 568
  
  Pfam
  PF04321 (RmlD_sub_bind)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

386 - 682

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

13 - 205

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

233 - 266

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

299 - 319

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
G3DSA:3.90.25.10

320 - 327

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)

206 - 232

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)

267 - 298

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)
PTHR43000 (DTDP-D-G...)

7 - 677

PANTHER
PTHR43000 (DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED)
PTHR43000:SF28 (TRI...)

7 - 677

PANTHER
PTHR43000:SF28 (TRIFUNCTIONAL UDP-GLUCOSE 4,6-DEHYDRATASE/UDP-4-KETO-6-DEOXY-D-GLUCOSE 3,5-EPIMERASE/UDP-4-KETO-L-RHAMNOSE-REDUCTASE RHM1-LIKE)
cd05254 (dTDP_HR_li...)

396 - 668

CDD
cd05254 (dTDP_HR_like_SDR_e)

Residue annotation

NAD binding site c...

18G

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

20A

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

21G

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

22F

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

23I

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

44D

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

45K

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

46L

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

47D

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

49C

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

50S

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

69G

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

70D

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

71I

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

92F

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

93A

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

94A

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

96T

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

111N

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

135V

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

136S

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

137T

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

164Y

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

168K

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

191G

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

192N

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

193N

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)

194V

NAD binding site
18G, 20A, 21G, 22F, 23I, 44D, 45K, 46L, 47D, 49C, 50S, 69G, 70D, 71I, 92F, 93A, 94A, 96T, 111N, 135V, 136S, 137T, 164Y, 168K, 191G, 192N, 193N, 194V
CDD
cd05246 (dTDP_GD_SDR_e)
substrate binding ...

96T

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

97H

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

98V

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

137T

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

138D

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

139E

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

164Y

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

191G

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

192N

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

193N

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

202E

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

203K

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

204L

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

207K

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

208F

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

219P

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

220I

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

221H

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

226N

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

228R

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

263V

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

288R

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

291N

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)

295Y

substrate binding site
96T, 97H, 98V, 137T, 138D, 139E, 164Y, 191G, 192N, 193N, 202E, 203K, 204L, 207K, 208F, 219P, 220I, 221H, 226N, 228R, 263V, 288R, 291N, 295Y
CDD
cd05246 (dTDP_GD_SDR_e)
homodimer interfac...

100N

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

102F

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

105S

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

106F

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

109T

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

113I

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

114Y

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

117H

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

121E

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

124K

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

143E

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

155A

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

157Q

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

158L

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

160P

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

161T

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

162N

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

163P

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

166A

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

169A

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

170G

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

173M

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

174L

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

177A

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

178Y

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

180R

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

181S

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

182Y

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)

292D

homodimer interface
100N, 102F, 105S, 106F, 109T, 113I, 114Y, 117H, 121E, 124K, 143E, 155A, 157Q, 158L, 160P, 161T, 162N, 163P, 166A, 169A, 170G, 173M, 174L, 177A, 178Y, 180R, 181S, 182Y, 292D
CDD
cd05246 (dTDP_GD_SDR_e)
active site cd05246

112N

active site
112N, 137T, 164Y, 168K
CDD
cd05246 (dTDP_GD_SDR_e)

137T

active site
112N, 137T, 164Y, 168K
CDD
cd05246 (dTDP_GD_SDR_e)

164Y

active site
112N, 137T, 164Y, 168K
CDD
cd05246 (dTDP_GD_SDR_e)

168K

active site
112N, 137T, 164Y, 168K
CDD
cd05246 (dTDP_GD_SDR_e)
NADP binding site ...

401G

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

403T

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

404G

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

405W

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

406I

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

426G

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

427R

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

428L

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

429E

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

449A

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

450A

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

451G

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

453T

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

471A

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

493F

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

494A

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

495T

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

526Y

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

530K

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

548V

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

549R

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

550M

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)

551P

NADP binding site
401G, 403T, 404G, 405W, 406I, 426G, 427R, 428L, 429E, 449A, 450A, 451G, 453T, 471A, 493F, 494A, 495T, 526Y, 530K, 548V, 549R, 550M, 551P
CDD
cd05254 (dTDP_HR_like_SDR_e)
active site cd05254

472N

active site
472N, 495T, 526Y, 530K
CDD
cd05254 (dTDP_HR_like_SDR_e)

495T

active site
472N, 495T, 526Y, 530K
CDD
cd05254 (dTDP_HR_like_SDR_e)

526Y

active site
472N, 495T, 526Y, 530K
CDD
cd05254 (dTDP_HR_like_SDR_e)

530K

active site
472N, 495T, 526Y, 530K
CDD
cd05254 (dTDP_HR_like_SDR_e)
putative substrate...

495T

putative substrate binding site
495T, 526Y, 550M, 566I, 571K, 577N
CDD
cd05254 (dTDP_HR_like_SDR_e)

526Y

putative substrate binding site
495T, 526Y, 550M, 566I, 571K, 577N
CDD
cd05254 (dTDP_HR_like_SDR_e)

550M

putative substrate binding site
495T, 526Y, 550M, 566I, 571K, 577N
CDD
cd05254 (dTDP_HR_like_SDR_e)

566I

putative substrate binding site
495T, 526Y, 550M, 566I, 571K, 577N
CDD
cd05254 (dTDP_HR_like_SDR_e)

571K

putative substrate binding site
495T, 526Y, 550M, 566I, 571K, 577N
CDD
cd05254 (dTDP_HR_like_SDR_e)

577N

putative substrate binding site
495T, 526Y, 550M, 566I, 571K, 577N
CDD
cd05254 (dTDP_HR_like_SDR_e)

GO term prediction

Biological Process

GO:0009225 nucleotide-sugar metabolic process

Molecular Function

GO:0008460 dTDP-glucose 4,6-dehydratase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features