Mp7g01760.2

Protein

Length

1,101 amino acids

Protein family membership

None predicted.

Homologous superfamilies

Homologous superfamily
1 - 414
AMP-dependent synthetase-like superfamily (IPR042099)
541 - 702
Thiamin diphosphate-binding fold (IPR029061)
731 - 886
DHS-like NAD/FAD-binding domain superfamily (IPR029035)
915 - 1,091
Thiamin diphosphate-binding fold (IPR029061)

1 200 400 600 800 1000 1101

Domains and repeats

Domain
13 - 421
AMP-dependent synthetase/ligase (IPR000873)
430 - 505
AMP-binding enzyme, C-terminal domain (IPR025110)
542 - 702
Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain (IPR012001)
737 - 862
Thiamine pyrophosphate enzyme, central domain (IPR012000)
933 - 1,084
Thiamine pyrophosphate enzyme, C-terminal TPP-binding (IPR011766)

1 200 400 600 800 1000 1101

Detailed signature matches

IPR042099

AMP-dependent synthetase-like superfamily
1. G3DSA:3.40.50...
  
  1 - 414
  
  GENE3D
  G3DSA:3.40.50.12780 (G3DSA:3.40.50.12780)
IPR029061

Thiamin diphosphate-binding fold
1. SSF52518 (Thiamin d...)
  
  915 - 1,091
  
  SUPERFAMILY
  SSF52518 (Thiamin diphosphate-binding fold (THDP-binding))
  
  541 - 702
  
  SUPERFAMILY
  SSF52518 (Thiamin diphosphate-binding fold (THDP-binding))
IPR029035

DHS-like NAD/FAD-binding domain superfamily
1. SSF52467 (DHS-like ...)
  
  731 - 886
  
  SUPERFAMILY
  SSF52467 (DHS-like NAD/FAD-binding domain)
IPR000873

AMP-dependent synthetase/ligase
1. PF00501 (AMP-binding)
  
  13 - 421
  
  Pfam
  PF00501 (AMP-binding)
IPR025110

AMP-binding enzyme, C-terminal domain
1. PF13193 (AMP-binding_C)
  
  430 - 505
  
  Pfam
  PF13193 (AMP-binding_C)
IPR012001

Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
1. PF02776 (TPP_enzyme_N)
  
  542 - 702
  
  Pfam
  PF02776 (TPP_enzyme_N)
IPR012000

Thiamine pyrophosphate enzyme, central domain
1. PF00205 (TPP_enzyme_M)
  
  737 - 862
  
  Pfam
  PF00205 (TPP_enzyme_M)
IPR011766

Thiamine pyrophosphate enzyme, C-terminal TPP-binding
1. PF02775 (TPP_enzyme_C)
  
  933 - 1,084
  
  Pfam
  PF02775 (TPP_enzyme_C)
IPR020845

AMP-binding, conserved site
1. PS00455 (AMP_BINDING)
  
  172 - 183
  
  PROSITE patterns
  PS00455 (AMP_BINDING)
IPR000399

TPP-binding enzyme, conserved site
1. PS00187 (TPP_ENZYMES)
  
  969 - 988
  
  PROSITE patterns
  PS00187 (TPP_ENZYMES)

no IPR

Unintegrated signatures

G3DSA:3.30.30...

417 - 520

GENE3D
G3DSA:3.30.300.310 (G3DSA:3.30.300.310)
G3DSA:3.40.50...

731 - 886

GENE3D
G3DSA:3.40.50.1220 (G3DSA:3.40.50.1220)
G3DSA:3.40.50...

887 - 1,101

GENE3D
G3DSA:3.40.50.970 (G3DSA:3.40.50.970)

527 - 717

GENE3D
G3DSA:3.40.50.970 (G3DSA:3.40.50.970)
PTHR43710 (2-HYDROX...)

531 - 1,100

PANTHER
PTHR43710 (2-HYDROXYACYL-COA LYASE)
PTHR43710:SF2 (2-HY...)

531 - 1,100

PANTHER
PTHR43710:SF2 (2-HYDROXYACYL-COA LYASE 1)
SSF56801 (Acetyl-Co...)

4 - 517

SUPERFAMILY
SSF56801 (Acetyl-CoA synthetase-like)
cd02004 (TPP_BZL_OC...)

908 - 1,087

CDD
cd02004 (TPP_BZL_OCoD_HPCL)
cd05926 (FACL_fum10...)

20 - 513

CDD
cd05926 (FACL_fum10p_like)
cd07035 (TPP_PYR_PO...)

542 - 692

CDD
cd07035 (TPP_PYR_POX_like)

Residue annotation

acyl-activating en...

172F

acyl-activating enzyme (AAE) consensus motif
172F, 175T, 176S, 177G, 178T, 179T, 180S, 182P, 183K
CDD
cd05926 (FACL_fum10p_like)

175T

acyl-activating enzyme (AAE) consensus motif
172F, 175T, 176S, 177G, 178T, 179T, 180S, 182P, 183K
CDD
cd05926 (FACL_fum10p_like)

176S

acyl-activating enzyme (AAE) consensus motif
172F, 175T, 176S, 177G, 178T, 179T, 180S, 182P, 183K
CDD
cd05926 (FACL_fum10p_like)

177G

acyl-activating enzyme (AAE) consensus motif
172F, 175T, 176S, 177G, 178T, 179T, 180S, 182P, 183K
CDD
cd05926 (FACL_fum10p_like)

178T

acyl-activating enzyme (AAE) consensus motif
172F, 175T, 176S, 177G, 178T, 179T, 180S, 182P, 183K
CDD
cd05926 (FACL_fum10p_like)

179T

acyl-activating enzyme (AAE) consensus motif
172F, 175T, 176S, 177G, 178T, 179T, 180S, 182P, 183K
CDD
cd05926 (FACL_fum10p_like)

180S

acyl-activating enzyme (AAE) consensus motif
172F, 175T, 176S, 177G, 178T, 179T, 180S, 182P, 183K
CDD
cd05926 (FACL_fum10p_like)

182P

acyl-activating enzyme (AAE) consensus motif
172F, 175T, 176S, 177G, 178T, 179T, 180S, 182P, 183K
CDD
cd05926 (FACL_fum10p_like)

183K

acyl-activating enzyme (AAE) consensus motif
172F, 175T, 176S, 177G, 178T, 179T, 180S, 182P, 183K
CDD
cd05926 (FACL_fum10p_like)
putative active si...

175T

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

215M

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

216P

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

265V

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

267T

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

268I

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

271I

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

293C

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

294S

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

315E

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

316A

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

317Y

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

318A

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

319M

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

320T

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

399D

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

411L

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

414R

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

422G

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

423G

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

424E

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

425K

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)

486F

putative active site
175T, 215M, 216P, 265V, 267T, 268I, 271I, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 422G, 423G, 424E, 425K, 486F
CDD
cd05926 (FACL_fum10p_like)
putative AMP bindi...

175T

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)

293C

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)

294S

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)

315E

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)

316A

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)

317Y

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)

318A

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)

319M

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)

320T

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)

399D

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)

411L

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)

414R

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)

425K

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)

505K

putative AMP binding site
175T, 293C, 294S, 315E, 316A, 317Y, 318A, 319M, 320T, 399D, 411L, 414R, 425K, 505K
CDD
cd05926 (FACL_fum10p_like)
putative CoA bindi...

215M

putative CoA binding site
215M, 267T, 268I, 271I, 293C, 422G, 423G, 424E, 480K, 486F
CDD
cd05926 (FACL_fum10p_like)

267T

putative CoA binding site
215M, 267T, 268I, 271I, 293C, 422G, 423G, 424E, 480K, 486F
CDD
cd05926 (FACL_fum10p_like)

268I

putative CoA binding site
215M, 267T, 268I, 271I, 293C, 422G, 423G, 424E, 480K, 486F
CDD
cd05926 (FACL_fum10p_like)

271I

putative CoA binding site
215M, 267T, 268I, 271I, 293C, 422G, 423G, 424E, 480K, 486F
CDD
cd05926 (FACL_fum10p_like)

293C

putative CoA binding site
215M, 267T, 268I, 271I, 293C, 422G, 423G, 424E, 480K, 486F
CDD
cd05926 (FACL_fum10p_like)

422G

putative CoA binding site
215M, 267T, 268I, 271I, 293C, 422G, 423G, 424E, 480K, 486F
CDD
cd05926 (FACL_fum10p_like)

423G

putative CoA binding site
215M, 267T, 268I, 271I, 293C, 422G, 423G, 424E, 480K, 486F
CDD
cd05926 (FACL_fum10p_like)

424E

putative CoA binding site
215M, 267T, 268I, 271I, 293C, 422G, 423G, 424E, 480K, 486F
CDD
cd05926 (FACL_fum10p_like)

480K

putative CoA binding site
215M, 267T, 268I, 271I, 293C, 422G, 423G, 424E, 480K, 486F
CDD
cd05926 (FACL_fum10p_like)

486F

putative CoA binding site
215M, 267T, 268I, 271I, 293C, 422G, 423G, 424E, 480K, 486F
CDD
cd05926 (FACL_fum10p_like)
PYR/PP interface c...

552H

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

557V

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

558G

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

562T

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

566T

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

574R

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

575F

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

576I

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

577A

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

578F

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

579H

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

580N

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

583S

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

586Y

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

587A

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

590A

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

591A

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

593Y

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

594L

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

595T

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

607P

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

614A

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

618N

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

621I

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)

622N

PYR/PP interface
552H, 557V, 558G, 562T, 566T, 574R, 575F, 576I, 577A, 578F, 579H, 580N, 583S, 586Y, 587A, 590A, 591A, 593Y, 594L, 595T, 607P, 614A, 618N, 621I, 622N
CDD
cd07035 (TPP_PYR_POX_like)
TPP binding site c...

557V

TPP binding site
557V, 581E, 607P, 611H
CDD
cd07035 (TPP_PYR_POX_like)

581E

TPP binding site
557V, 581E, 607P, 611H
CDD
cd07035 (TPP_PYR_POX_like)

607P

TPP binding site
557V, 581E, 607P, 611H
CDD
cd07035 (TPP_PYR_POX_like)

611H

TPP binding site
557V, 581E, 607P, 611H
CDD
cd07035 (TPP_PYR_POX_like)
dimer interface cd...

557V

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

558G

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

559I

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

562T

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

566T

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

575F

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

577A

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

578F

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

579H

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

580N

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

582Q

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

607P

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

610V

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

611H

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

613L

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

614A

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

617S

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

651I

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)

654P

dimer interface
557V, 558G, 559I, 562T, 566T, 575F, 577A, 578F, 579H, 580N, 582Q, 607P, 610V, 611H, 613L, 614A, 617S, 651I, 654P
CDD
cd07035 (TPP_PYR_POX_like)
TPP-binding site c...

908Y

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

933G

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

934A

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

935N

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

936T

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

959G

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

961M

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

985G

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

986D

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

987S

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

988G

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

1,013N

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

1,015G

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

1,017Y

TPP-binding site
908Y, 933G, 934A, 935N, 936T, 959G, 961M, 985G, 986D, 987S, 988G, 1,013N, 1,015G, 1,017Y
CDD
cd02004 (TPP_BZL_OCoD_HPCL)
dimer interface cd...

958W

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

986D

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

990G

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

991F

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

994M

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

997E

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

1,021R

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

1,036A

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

1,038T

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

1,042P

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

1,045R

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

1,046Y

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

1,048I

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

1,052A

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

1,053F

dimer interface
958W, 986D, 990G, 991F, 994M, 997E, 1,021R, 1,036A, 1,038T, 1,042P, 1,045R, 1,046Y, 1,048I, 1,052A, 1,053F
CDD
cd02004 (TPP_BZL_OCoD_HPCL)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0030976 thiamine pyrophosphate binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features

Mp7g01760.2

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component