Mp7g03840.1

Protein

Length

319 amino acids

Protein family membership

Geranylgeranyl transferase type-2 subunit beta (IPR026873)

Homologous superfamilies

Homologous superfamily
6 - 313
Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid (IPR008930)

1 50 100 150 200 250 319

Domains and repeats

Repeat
57 - 97
PFTB repeat (IPR001330)
105 - 146
PFTB repeat (IPR001330)
152 - 195
PFTB repeat (IPR001330)
201 - 243
PFTB repeat (IPR001330)
248 - 291
PFTB repeat (IPR001330)

1 50 100 150 200 250 319

Detailed signature matches

IPR008930

Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
1. SSF48239 (Terpenoid...)
  
  6 - 313
  
  SUPERFAMILY
  SSF48239 (Terpenoid cyclases/Protein prenyltransferases)
IPR026873

Geranylgeranyl transferase type-2 subunit beta
1. cd02894 (GGTase-II)
  
  9 - 291
  
  CDD
  cd02894 (GGTase-II)
IPR001330

PFTB repeat
1. PF00432 (Prenyltrans)
  
  248 - 291
  
  Pfam
  PF00432 (Prenyltrans)
  
  57 - 97
  
  Pfam
  PF00432 (Prenyltrans)
  
  201 - 243
  
  Pfam
  PF00432 (Prenyltrans)
  
  152 - 195
  
  Pfam
  PF00432 (Prenyltrans)
  
  105 - 146
  
  Pfam
  PF00432 (Prenyltrans)

no IPR

Unintegrated signatures

G3DSA:1.50.10.20

1 - 318

GENE3D
G3DSA:1.50.10.20 (G3DSA:1.50.10.20)
PTHR11774 (GERANYLG...)

4 - 316

PANTHER
PTHR11774 (GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT)
PTHR11774:SF13 (GER...)

4 - 316

PANTHER
PTHR11774:SF13 (GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA)

Residue annotation

active site cavity...

31V

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

34H

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

35L

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

38S

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

42W

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

84H

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

86L

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

87Y

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

89L

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

90N

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

134R

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

137Y

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

138A

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

180H

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

182G

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

186C

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

228D

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

230C

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

231Y

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

234W

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

270D

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

279F

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)

280H

active site cavity
31V, 34H, 35L, 38S, 42W, 84H, 86L, 87Y, 89L, 90N, 134R, 137Y, 138A, 180H, 182G, 186C, 228D, 230C, 231Y, 234W, 270D, 279F, 280H
CDD
cd02894 (GGTase-II)
peptide binding po...

34H

peptide binding pocket
34H, 35L, 38S, 86L, 87Y, 134R, 228D, 270D
CDD
cd02894 (GGTase-II)

35L

peptide binding pocket
34H, 35L, 38S, 86L, 87Y, 134R, 228D, 270D
CDD
cd02894 (GGTase-II)

38S

peptide binding pocket
34H, 35L, 38S, 86L, 87Y, 134R, 228D, 270D
CDD
cd02894 (GGTase-II)

86L

peptide binding pocket
34H, 35L, 38S, 86L, 87Y, 134R, 228D, 270D
CDD
cd02894 (GGTase-II)

87Y

peptide binding pocket
34H, 35L, 38S, 86L, 87Y, 134R, 228D, 270D
CDD
cd02894 (GGTase-II)

134R

peptide binding pocket
34H, 35L, 38S, 86L, 87Y, 134R, 228D, 270D
CDD
cd02894 (GGTase-II)

228D

peptide binding pocket
34H, 35L, 38S, 86L, 87Y, 134R, 228D, 270D
CDD
cd02894 (GGTase-II)

270D

peptide binding pocket
34H, 35L, 38S, 86L, 87Y, 134R, 228D, 270D
CDD
cd02894 (GGTase-II)
lipid binding pock...

38S

lipid binding pocket
38S, 41Y, 134R, 137Y, 180H, 182G, 186C, 222R, 225K, 231Y, 234W, 279F
CDD
cd02894 (GGTase-II)

41Y

lipid binding pocket
38S, 41Y, 134R, 137Y, 180H, 182G, 186C, 222R, 225K, 231Y, 234W, 279F
CDD
cd02894 (GGTase-II)

134R

lipid binding pocket
38S, 41Y, 134R, 137Y, 180H, 182G, 186C, 222R, 225K, 231Y, 234W, 279F
CDD
cd02894 (GGTase-II)

137Y

lipid binding pocket
38S, 41Y, 134R, 137Y, 180H, 182G, 186C, 222R, 225K, 231Y, 234W, 279F
CDD
cd02894 (GGTase-II)

180H

lipid binding pocket
38S, 41Y, 134R, 137Y, 180H, 182G, 186C, 222R, 225K, 231Y, 234W, 279F
CDD
cd02894 (GGTase-II)

182G

lipid binding pocket
38S, 41Y, 134R, 137Y, 180H, 182G, 186C, 222R, 225K, 231Y, 234W, 279F
CDD
cd02894 (GGTase-II)

186C

lipid binding pocket
38S, 41Y, 134R, 137Y, 180H, 182G, 186C, 222R, 225K, 231Y, 234W, 279F
CDD
cd02894 (GGTase-II)

222R

lipid binding pocket
38S, 41Y, 134R, 137Y, 180H, 182G, 186C, 222R, 225K, 231Y, 234W, 279F
CDD
cd02894 (GGTase-II)

225K

lipid binding pocket
38S, 41Y, 134R, 137Y, 180H, 182G, 186C, 222R, 225K, 231Y, 234W, 279F
CDD
cd02894 (GGTase-II)

231Y

lipid binding pocket
38S, 41Y, 134R, 137Y, 180H, 182G, 186C, 222R, 225K, 231Y, 234W, 279F
CDD
cd02894 (GGTase-II)

234W

lipid binding pocket
38S, 41Y, 134R, 137Y, 180H, 182G, 186C, 222R, 225K, 231Y, 234W, 279F
CDD
cd02894 (GGTase-II)

279F

lipid binding pocket
38S, 41Y, 134R, 137Y, 180H, 182G, 186C, 222R, 225K, 231Y, 234W, 279F
CDD
cd02894 (GGTase-II)
heterodimer interf...

129G

heterodimer interface
129G, 167F, 177G, 178E, 183Q, 207W, 210C, 212R, 213Q, 222R, 223P, 224E
CDD
cd02894 (GGTase-II)

167F

heterodimer interface
129G, 167F, 177G, 178E, 183Q, 207W, 210C, 212R, 213Q, 222R, 223P, 224E
CDD
cd02894 (GGTase-II)

177G

heterodimer interface
129G, 167F, 177G, 178E, 183Q, 207W, 210C, 212R, 213Q, 222R, 223P, 224E
CDD
cd02894 (GGTase-II)

178E

heterodimer interface
129G, 167F, 177G, 178E, 183Q, 207W, 210C, 212R, 213Q, 222R, 223P, 224E
CDD
cd02894 (GGTase-II)

183Q

heterodimer interface
129G, 167F, 177G, 178E, 183Q, 207W, 210C, 212R, 213Q, 222R, 223P, 224E
CDD
cd02894 (GGTase-II)

207W

heterodimer interface
129G, 167F, 177G, 178E, 183Q, 207W, 210C, 212R, 213Q, 222R, 223P, 224E
CDD
cd02894 (GGTase-II)

210C

heterodimer interface
129G, 167F, 177G, 178E, 183Q, 207W, 210C, 212R, 213Q, 222R, 223P, 224E
CDD
cd02894 (GGTase-II)

212R

heterodimer interface
129G, 167F, 177G, 178E, 183Q, 207W, 210C, 212R, 213Q, 222R, 223P, 224E
CDD
cd02894 (GGTase-II)

213Q

heterodimer interface
129G, 167F, 177G, 178E, 183Q, 207W, 210C, 212R, 213Q, 222R, 223P, 224E
CDD
cd02894 (GGTase-II)

222R

heterodimer interface
129G, 167F, 177G, 178E, 183Q, 207W, 210C, 212R, 213Q, 222R, 223P, 224E
CDD
cd02894 (GGTase-II)

223P

heterodimer interface
129G, 167F, 177G, 178E, 183Q, 207W, 210C, 212R, 213Q, 222R, 223P, 224E
CDD
cd02894 (GGTase-II)

224E

heterodimer interface
129G, 167F, 177G, 178E, 183Q, 207W, 210C, 212R, 213Q, 222R, 223P, 224E
CDD
cd02894 (GGTase-II)
Zn2+ binding site ...

228D

Zn2+ binding site
228D, 230C, 280H
CDD
cd02894 (GGTase-II)

230C

Zn2+ binding site
228D, 230C, 280H
CDD
cd02894 (GGTase-II)

280H

Zn2+ binding site
228D, 230C, 280H
CDD
cd02894 (GGTase-II)

GO term prediction

Biological Process

GO:0018344 protein geranylgeranylation

Molecular Function

GO:0003824 catalytic activity
GO:0004663 Rab geranylgeranyltransferase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features