Mp7g11730.1

Protein

Length

819 amino acids

Protein family membership

Phosphatidylinositol kinase (IPR015433)
- Phosphatidylinositol 3-kinase, Vps34 type (IPR008290)

Homologous superfamilies

Homologous superfamily
44 - 178
C2 domain superfamily (IPR035892)
280 - 459
Armadillo-type fold (IPR016024)
473 - 811
Protein kinase-like domain superfamily (IPR011009)
Homologous superfamily
256 - 459
Phosphoinositide 3-kinase, accessory (PIK) domain superfamily (IPR042236)
620 - 819
Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily (IPR036940)

1 100 200 300 400 500 600 700 819

Domains and repeats

Domain
18 - 202
Phosphatidylinositol 3-kinase, C2 domain (IPR002420)
286 - 471
Phosphoinositide 3-kinase, accessory (PIK) domain (IPR001263)
564 - 818
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)

1 100 200 300 400 500 600 700 819

Detailed signature matches

IPR035892

C2 domain superfamily
1. G3DSA:2.60.40...
  
  44 - 178
  
  GENE3D
  G3DSA:2.60.40.150 (G3DSA:2.60.40.150)
IPR042236

Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
1. G3DSA:1.25.40.70
  
  256 - 459
  
  GENE3D
  G3DSA:1.25.40.70 (G3DSA:1.25.40.70)
IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  280 - 459
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR011009

Protein kinase-like domain superfamily
1. SSF56112 (Protein k...)
  
  473 - 811
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR036940

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
1. G3DSA:1.10.10...
  
  620 - 819
  
  GENE3D
  G3DSA:1.10.1070.11 (G3DSA:1.10.1070.11)
IPR015433

Phosphatidylinositol kinase
1. PTHR10048 (PHOSPHAT...)
  
  49 - 814
  
  PANTHER
  PTHR10048 (PHOSPHATIDYLINOSITOL KINASE)
IPR008290

Phosphatidylinositol 3-kinase, Vps34 type
1. PIRSF000587 (PI3K_V...)
  
  410 - 819
  
  PIRSF
  PIRSF000587 (PI3K_Vps34)
  
  5 - 416
  
  PIRSF
  PIRSF000587 (PI3K_Vps34)
IPR002420

Phosphatidylinositol 3-kinase, C2 domain
1. PS51547 (PI3K_C2)
  
  18 - 190
  
  PROSITE profiles
  PS51547 (PI3K_C2)
2. PF00792 (PI3K_C2)
  
  61 - 202
  
  Pfam
  PF00792 (PI3K_C2)
3. SM00142 (pi3k_hr3_6)
  
  33 - 136
  
  SMART
  SM00142 (pi3k_hr3_6)
IPR001263

Phosphoinositide 3-kinase, accessory (PIK) domain
1. PF00613 (PI3Ka)
  
  288 - 464
  
  Pfam
  PF00613 (PI3Ka)
2. SM00145 (pi3k_hr2_4)
  
  286 - 471
  
  SMART
  SM00145 (pi3k_hr2_4)
3. PS51545 (PIK_HELICAL)
  
  286 - 461
  
  PROSITE profiles
  PS51545 (PIK_HELICAL)
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. PS50290 (PI3_4_KINA...)
  
  564 - 818
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
2. SM00146 (pi3k_hr1_6)
  
  565 - 817
  
  SMART
  SM00146 (pi3k_hr1_6)
3. PF00454 (PI3_PI4_ki...)
  
  633 - 765
  
  Pfam
  PF00454 (PI3_PI4_kinase)
  
  564 - 630
  
  Pfam
  PF00454 (PI3_PI4_kinase)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00916 (PI3_4_KINA...)
  
  661 - 681
  
  PROSITE patterns
  PS00916 (PI3_4_KINASE_2)
2. PS00915 (PI3_4_KINA...)
  
  568 - 582
  
  PROSITE patterns
  PS00915 (PI3_4_KINASE_1)

no IPR

Unintegrated signatures

G3DSA:3.30.10...

470 - 619

GENE3D
G3DSA:3.30.1010.10 (G3DSA:3.30.1010.10)
PTHR10048:SF7 (PHOS...)

49 - 814

PANTHER
PTHR10048:SF7 (PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3)
SSF49562 (C2 domain...)

61 - 170

SUPERFAMILY
SSF49562 (C2 domain (Calcium/lipid-binding domain, CaLB))
cd00870 (PI3Ka_III)

286 - 444

CDD
cd00870 (PI3Ka_III)
cd00896 (PI3Kc_III)

472 - 816

CDD
cd00896 (PI3Kc_III)
cd08397 (C2_PI3K_cl...)

58 - 191

CDD
cd08397 (C2_PI3K_class_III)

Residue annotation

ATP binding site c...

545F

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

547S

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

548T

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

549L

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

551P

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

567I

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

569K

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

572D

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

603Y

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

615V

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

616E

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

617F

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

618V

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

622S

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

625Q

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

681N

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

683L

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

693I

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)

694D

ATP binding site
545F, 547S, 548T, 549L, 551P, 567I, 569K, 572D, 603Y, 615V, 616E, 617F, 618V, 622S, 625Q, 681N, 683L, 693I, 694D
CDD
cd00896 (PI3Kc_III)
catalytic loop cd0...

673G

catalytic loop
673G, 674V, 675G, 676D, 677R, 678H, 679L, 680D, 681N
CDD
cd00896 (PI3Kc_III)

674V

catalytic loop
673G, 674V, 675G, 676D, 677R, 678H, 679L, 680D, 681N
CDD
cd00896 (PI3Kc_III)

675G

catalytic loop
673G, 674V, 675G, 676D, 677R, 678H, 679L, 680D, 681N
CDD
cd00896 (PI3Kc_III)

676D

catalytic loop
673G, 674V, 675G, 676D, 677R, 678H, 679L, 680D, 681N
CDD
cd00896 (PI3Kc_III)

677R

catalytic loop
673G, 674V, 675G, 676D, 677R, 678H, 679L, 680D, 681N
CDD
cd00896 (PI3Kc_III)

678H

catalytic loop
673G, 674V, 675G, 676D, 677R, 678H, 679L, 680D, 681N
CDD
cd00896 (PI3Kc_III)

679L

catalytic loop
673G, 674V, 675G, 676D, 677R, 678H, 679L, 680D, 681N
CDD
cd00896 (PI3Kc_III)

680D

catalytic loop
673G, 674V, 675G, 676D, 677R, 678H, 679L, 680D, 681N
CDD
cd00896 (PI3Kc_III)

681N

catalytic loop
673G, 674V, 675G, 676D, 677R, 678H, 679L, 680D, 681N
CDD
cd00896 (PI3Kc_III)
activation loop (A...

694D

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

695F

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

696G

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

697F

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

698I

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

699L

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

700G

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

701R

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

702D

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

703P

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

704K

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

705P

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

706F

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

707P

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

708P

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

709P

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

710M

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

711K

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

712L

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

713C

activation loop (A-loop)
694D, 695F, 696G, 697F, 698I, 699L, 700G, 701R, 702D, 703P, 704K, 705P, 706F, 707P, 708P, 709P, 710M, 711K, 712L, 713C
CDD
cd00896 (PI3Kc_III)

GO term prediction

Biological Process

GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling

Molecular Function

GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features