Mp7g19180.2

Protein

Length

397 amino acids

Protein family membership

UDP-glucose 4-epimerase (IPR005886)

Homologous superfamilies

Homologous superfamily
51 - 388
NAD(P)-binding domain superfamily (IPR036291)

1 50 100 150 200 250 300 350 397

Domains and repeats

Domain
53 - 368
NAD(P)-binding domain (IPR016040)

1 50 100 150 200 250 300 350 397

Detailed signature matches

IPR036291

NAD(P)-binding domain superfamily
1. SSF51735 (NAD(P)-bi...)
  
  51 - 388
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR005886

UDP-glucose 4-epimerase
1. TIGR01179
  
  52 - 389
  
  TIGRFAMs
  TIGR01179 (TIGR01179)
2. cd05247 (UDP_G4E_1_...)
  
  51 - 384
  
  CDD
  cd05247 (UDP_G4E_1_SDR_e)
IPR016040

NAD(P)-binding domain
1. PF16363 (GDP_Man_Dehyd)
  
  53 - 368
  
  Pfam
  PF16363 (GDP_Man_Dehyd)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

52 - 244

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)

298 - 327

GENE3D
G3DSA:3.40.50.720 (G3DSA:3.40.50.720)
G3DSA:3.90.25.10

245 - 297

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)

328 - 383

GENE3D
G3DSA:3.90.25.10 (G3DSA:3.90.25.10)
PTHR43349 (PINORESI...)

27 - 383

PANTHER
PTHR43349 (PINORESINOL REDUCTASE-RELATED)
PTHR43349:SF75 (UDP...)

27 - 383

PANTHER
PTHR43349:SF75 (UDP-ARABINOSE 4-EPIMERASE 3-RELATED)

Residue annotation

NAD binding site c...

56G

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

58A

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

59G

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

60Y

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

61I

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

80D

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

81N

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

82L

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

83S

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

84R

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

85G

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

108A

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

109D

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

110L

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

131F

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

132A

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

133A

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

135A

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

150N

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

173S

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

174S

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

175T

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

199Y

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

203K

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

228Y

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

229F

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)

231V

NAD binding site
56G, 58A, 59G, 60Y, 61I, 80D, 81N, 82L, 83S, 84R, 85G, 108A, 109D, 110L, 131F, 132A, 133A, 135A, 150N, 173S, 174S, 175T, 199Y, 203K, 228Y, 229F, 231V
CDD
cd05247 (UDP_G4E_1_SDR_e)
homodimer interfac...

141M

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

143E

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

144P

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

145L

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

148Y

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

149H

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

152T

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

153S

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

156L

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

157G

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

159L

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

160E

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

163V

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

198P

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

201K

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

205M

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

208E

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

209I

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

211M

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

212D

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)

213Y

homodimer interface
141M, 143E, 144P, 145L, 148Y, 149H, 152T, 153S, 156L, 157G, 159L, 160E, 163V, 198P, 201K, 205M, 208E, 209I, 211M, 212D, 213Y
CDD
cd05247 (UDP_G4E_1_SDR_e)
active site cd05247

151I

active site
151I, 175T, 199Y, 203K
CDD
cd05247 (UDP_G4E_1_SDR_e)

175T

active site
151I, 175T, 199Y, 203K
CDD
cd05247 (UDP_G4E_1_SDR_e)

199Y

active site
151I, 175T, 199Y, 203K
CDD
cd05247 (UDP_G4E_1_SDR_e)

203K

active site
151I, 175T, 199Y, 203K
CDD
cd05247 (UDP_G4E_1_SDR_e)
substrate binding ...

175T

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

176C

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

177A

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

199Y

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

228Y

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

229F

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

230N

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

252G

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

253R

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

254I

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

269L

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

270Q

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

271V

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

272K

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

283C

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

285R

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

287Y

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

322V

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

345R

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

348D

substrate binding site
175T, 176C, 177A, 199Y, 228Y, 229F, 230N, 252G, 253R, 254I, 269L, 270Q, 271V, 272K, 283C, 285R, 287Y, 322V, 345R, 348D
CDD
cd05247 (UDP_G4E_1_SDR_e)

GO term prediction

Biological Process

GO:0006012 galactose metabolic process

Molecular Function

GO:0003978 UDP-glucose 4-epimerase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features