Mp8g12440.1

Protein

Length

401 amino acids

Protein family membership

Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y (IPR017597)

Homologous superfamilies

Homologous superfamily
65 - 383
Thiamin diphosphate-binding fold (IPR029061)

1 50 100 150 200 250 300 350 401

Domains and repeats

Domain
77 - 371
Dehydrogenase, E1 component (IPR001017)

1 50 100 150 200 250 300 350 401

Detailed signature matches

IPR029061

Thiamin diphosphate-binding fold
1. SSF52518 (Thiamin d...)
  
  65 - 383
  
  SUPERFAMILY
  SSF52518 (Thiamin diphosphate-binding fold (THDP-binding))
IPR017597

Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
1. TIGR03182
  
  69 - 381
  
  TIGRFAMs
  TIGR03182 (TIGR03182)
IPR001017

Dehydrogenase, E1 component
1. PF00676 (E1_dh)
  
  77 - 371
  
  Pfam
  PF00676 (E1_dh)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

34 - 399

GENE3D
G3DSA:3.40.50.970 (G3DSA:3.40.50.970)
PTHR11516 (PYRUVATE...)

44 - 399

PANTHER
PTHR11516 (PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR)
PTHR11516:SF65 (PYR...)

44 - 399

PANTHER
PTHR11516:SF65 (PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, MITOCHONDRIAL)
cd02000 (TPP_E1_PDC...)

74 - 364

CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

Other features

Coil

343 - 363

COILS
Coil (Coil)

Residue annotation

tetramer interface...

98R

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

150G

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

177G

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

178I

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

209G

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

211A

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

212N

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

213Q

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

214G

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

217F

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

221N

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

225L

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

240G

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

241M

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

242G

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

243T

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

257R

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

260Y

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

307D

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

311T

tetramer interface
98R, 150G, 177G, 178I, 209G, 211A, 212N, 213Q, 214G, 217F, 221N, 225L, 240G, 241M, 242G, 243T, 257R, 260Y, 307D, 311T
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)
TPP-binding site c...

128Y

TPP-binding site
128Y, 129R, 177G, 179V, 207G, 208D, 209G, 210A, 237N, 239Y, 303H
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

129R

TPP-binding site
128Y, 129R, 177G, 179V, 207G, 208D, 209G, 210A, 237N, 239Y, 303H
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

177G

TPP-binding site
128Y, 129R, 177G, 179V, 207G, 208D, 209G, 210A, 237N, 239Y, 303H
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

179V

TPP-binding site
128Y, 129R, 177G, 179V, 207G, 208D, 209G, 210A, 237N, 239Y, 303H
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

207G

TPP-binding site
128Y, 129R, 177G, 179V, 207G, 208D, 209G, 210A, 237N, 239Y, 303H
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

208D

TPP-binding site
128Y, 129R, 177G, 179V, 207G, 208D, 209G, 210A, 237N, 239Y, 303H
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

209G

TPP-binding site
128Y, 129R, 177G, 179V, 207G, 208D, 209G, 210A, 237N, 239Y, 303H
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

210A

TPP-binding site
128Y, 129R, 177G, 179V, 207G, 208D, 209G, 210A, 237N, 239Y, 303H
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

237N

TPP-binding site
128Y, 129R, 177G, 179V, 207G, 208D, 209G, 210A, 237N, 239Y, 303H
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

239Y

TPP-binding site
128Y, 129R, 177G, 179V, 207G, 208D, 209G, 210A, 237N, 239Y, 303H
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

303H

TPP-binding site
128Y, 129R, 177G, 179V, 207G, 208D, 209G, 210A, 237N, 239Y, 303H
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)
heterodimer interf...

172F

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

174G

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

176N

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

181A

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

184P

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

185L

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

188G

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

189L

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

191F

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

192A

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

195Y

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

214G

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

215Q

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

221N

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

222I

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

225L

heterodimer interface
172F, 174G, 176N, 181A, 184P, 185L, 188G, 189L, 191F, 192A, 195Y, 214G, 215Q, 221N, 222I, 225L
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)
phosphorylation lo...

298Y

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

299R

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

300Y

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

301H

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

302G

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

303H

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

304S

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

306S

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

307D

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

308P

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

309G

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

310S

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

311T

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

312Y

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

313R

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

314T

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

315R

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

316D

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

325R

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

326D

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

327P

phosphorylation loop region
298Y, 299R, 300Y, 301H, 302G, 303H, 304S, 306S, 307D, 308P, 309G, 310S, 311T, 312Y, 313R, 314T, 315R, 316D, 325R, 326D, 327P
CDD
cd02000 (TPP_E1_PDC_ADC_BCADC)

GO term prediction

Biological Process

GO:0006086 acetyl-CoA biosynthetic process from pyruvate

Molecular Function

GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

Cellular Component

GO:0043231 intracellular membrane-bounded organelle

Filter view on

Entry type

Status

Per-residue features