Mp8g18560.2

Protein

Length

2,451 amino acids

Protein family membership

None predicted.

Homologous superfamilies

None predicted.

Domains and repeats

Domain
1,234 - 1,288
Zinc finger, CW-type (IPR011124)
1,350 - 1,401
AWS domain (IPR006560)
1,527 - 1,543
Post-SET domain (IPR003616)
Domain
1,401 - 1,543
SET domain (IPR001214)
SETD2/Set2, SET domain (IPR044437)

1 500 1000 1500 2000 2451

Detailed signature matches

IPR011124

Zinc finger, CW-type
1. PF07496 (zf-CW)
  
  1,240 - 1,285
  
  Pfam
  PF07496 (zf-CW)
2. PS51050 (ZF_CW)
  
  1,234 - 1,288
  
  PROSITE profiles
  PS51050 (ZF_CW)
IPR006560

AWS domain
1. SM00570 (shorttest3)
  
  1,350 - 1,401
  
  SMART
  SM00570 (shorttest3)
2. PS51215 (AWS)
  
  1,350 - 1,400
  
  PROSITE profiles
  PS51215 (AWS)
3. PF17907 (AWS)
  
  1,363 - 1,399
  
  Pfam
  PF17907 (AWS)
IPR001214

SET domain
1. PF00856 (SET)
  
  1,419 - 1,519
  
  Pfam
  PF00856 (SET)
2. PS50280 (SET)
  
  1,402 - 1,519
  
  PROSITE profiles
  PS50280 (SET)
3. SM00317 (set_7)
  
  1,402 - 1,525
  
  SMART
  SM00317 (set_7)
IPR044437

SETD2/Set2, SET domain
1. cd19172 (SET_SETD2)
  
  1,401 - 1,543
  
  CDD
  cd19172 (SET_SETD2)
IPR003616

Post-SET domain
1. PS50868 (POST_SET)
  
  1,527 - 1,543
  
  PROSITE profiles
  PS50868 (POST_SET)

no IPR

Unintegrated signatures

G3DSA:2.170.2... (S...)

1,302 - 1,561

GENE3D
G3DSA:2.170.270.10 (SET domain)
G3DSA:3.30.40...

1,233 - 1,294

GENE3D
G3DSA:3.30.40.100 (G3DSA:3.30.40.100)
PTHR22884 (SET DOMA...)

587 - 2,038

PANTHER
PTHR22884 (SET DOMAIN PROTEINS)
PTHR22884:SF413 (HI...)

587 - 2,038

PANTHER
PTHR22884:SF413 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-36 SPECIFIC)
SSF82199 (SET domain)

1,324 - 1,540

SUPERFAMILY
SSF82199 (SET domain)

Other features

mobidb-lite (disord...)

354 - 477

MobiDB Lite
mobidb-lite (disorder_prediction)

805 - 832

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 98

MobiDB Lite
mobidb-lite (disorder_prediction)

636 - 661

MobiDB Lite
mobidb-lite (disorder_prediction)

277 - 300

MobiDB Lite
mobidb-lite (disorder_prediction)

891 - 969

MobiDB Lite
mobidb-lite (disorder_prediction)

179 - 245

MobiDB Lite
mobidb-lite (disorder_prediction)

1,843 - 1,942

MobiDB Lite
mobidb-lite (disorder_prediction)

2,265 - 2,292

MobiDB Lite
mobidb-lite (disorder_prediction)

611 - 630

MobiDB Lite
mobidb-lite (disorder_prediction)

1,070 - 1,107

MobiDB Lite
mobidb-lite (disorder_prediction)

572 - 604

MobiDB Lite
mobidb-lite (disorder_prediction)

1,162 - 1,226

MobiDB Lite
mobidb-lite (disorder_prediction)

1,966 - 2,020

MobiDB Lite
mobidb-lite (disorder_prediction)

715 - 741

MobiDB Lite
mobidb-lite (disorder_prediction)
mobidb-lite (Negati...)

79 - 98

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Negative Polyelectrolyte
mobidb-lite (Polyam...)

721 - 737

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

1,163 - 1,182

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

12 - 31

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

948 - 969

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

1,925 - 1,942

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

818 - 832

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte

286 - 300

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polyampholyte
mobidb-lite (Polar)

1,184 - 1,199

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

1,968 - 2,010

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

1,070 - 1,100

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

405 - 425

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

1,843 - 1,870

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

1,878 - 1,924

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

360 - 375

MobiDB Lite
mobidb-lite (disorder_prediction)
Feature: Polar

Residue annotation

SAM binding site c...

1,412K

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,413G

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,414F

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,454K

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,455H

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,456F

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,457Y

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,477R

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,478F

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,479I

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,480N

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,481H

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,518Y

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,529K

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,530K

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,531C

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,532E

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,533C

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,542I

SAM binding site
1,412K, 1,413G, 1,414F, 1,454K, 1,455H, 1,456F, 1,457Y, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,518Y, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)
active site cd19172

1,412K

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,413G

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,414F

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,431Y

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,441F

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,445Q

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,449A

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,454K

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,455H

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,456F

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,457Y

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,458F

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,459M

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,460T

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,477R

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,478F

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,479I

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,480N

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,481H

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,488K

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,489T

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,490E

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,505I

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,516F

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,517D

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,518Y

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,519N

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,520Y

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,522R

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,523V

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,525G

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,526A

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,527S

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,529K

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,530K

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,531C

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,532E

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,533C

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)

1,542I

active site
1,412K, 1,413G, 1,414F, 1,431Y, 1,441F, 1,445Q, 1,449A, 1,454K, 1,455H, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,477R, 1,478F, 1,479I, 1,480N, 1,481H, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y, 1,522R, 1,523V, 1,525G, 1,526A, 1,527S, 1,529K, 1,530K, 1,531C, 1,532E, 1,533C, 1,542I
CDD
cd19172 (SET_SETD2)
polypeptide substr...

1,431Y

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,441F

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,445Q

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,456F

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,457Y

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,458F

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,459M

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,460T

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,488K

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,489T

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,490E

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,505I

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,516F

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,517D

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,518Y

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,519N

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)

1,520Y

polypeptide substrate binding site
1,431Y, 1,441F, 1,445Q, 1,456F, 1,457Y, 1,458F, 1,459M, 1,460T, 1,488K, 1,489T, 1,490E, 1,505I, 1,516F, 1,517D, 1,518Y, 1,519N, 1,520Y
CDD
cd19172 (SET_SETD2)
Zn binding site cd...

1,483C

Zn binding site
1,483C, 1,531C, 1,533C, 1,538C
CDD
cd19172 (SET_SETD2)

1,531C

Zn binding site
1,483C, 1,531C, 1,533C, 1,538C
CDD
cd19172 (SET_SETD2)

1,533C

Zn binding site
1,483C, 1,531C, 1,533C, 1,538C
CDD
cd19172 (SET_SETD2)

1,538C

Zn binding site
1,483C, 1,531C, 1,533C, 1,538C
CDD
cd19172 (SET_SETD2)

GO term prediction

Biological Process

GO:0010452 histone H3-K36 methylation

Molecular Function

GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046975 histone methyltransferase activity (H3-K36 specific)

Cellular Component

GO:0005634 nucleus

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Entry type

Status

Per-residue features