Mp5g18040



Description

Annotation

Database ID Description
MobiDBLite mobidb-lite consensus disorder prediction
SUPERFAMILY SSF82199 SET domain
ProSiteProfiles PS50280 SET domain profile.
Pfam PF00856 SET domain
CDD cd10519 SET_EZH
PANTHER PTHR45747 HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)
Gene3D G3DSA:2.170.270.10 SET domain
ProSiteProfiles PS51576 Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile.
FunFam G3DSA:2.170.270.10:FF:000001 Putative histone-lysine N-methyltransferase EZH2
Pfam PF18264 CXC domain
ProSiteProfiles PS51633 CXC domain profile.
SMART SM00317 set_7
Coils Coil Coil
SMART SM01114 CXC_2
KOG KOG1079 Transcriptional repressor EZH1; N-term missing; [K]
KOG KOG1079 Transcriptional repressor EZH1; C-term missing; [K]
KOG KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily; C-term missing; [K]
MapolyID Mapoly0084s0051 -
GO GO:0031519 PcG protein complex
GO GO:0005634 nucleus
GO GO:0006338 chromatin remodeling
GO GO:0005515 protein binding
GO GO:0031507 heterochromatin formation
GO GO:0042054 histone methyltransferase activity
GO GO:0046976 histone H3K27 methyltransferase activity
GO GO:0003682 chromatin binding

Nomenclature

Gene symbol Product Transcript ID Status
MpCXC3 transcription factor, CXC Published
MpE(z)1 E(z)1 Published
PRC2 complex subunit, actively represses MpKNOX2 and MpBELL1 in the vegetative gametophyte.

Associated Literature (AI-based literature mining, Beta-version)

MpE(z)1 (Enhancer of zeste homolog) is the catalytic PRC2 subunit; the Mpknox2 Mpe(z)1 double mutant with reduced PRC2 activity was analysed by ChIP, showing depletion of H3K27me3 at facultative-heterochromatin states while H2Aub was retained.

2 core 2 peripheral

Shukla V, Axelsson E, Hisanaga T, Haseloff J, Berger F, Romani F. (2026) · PLoS genetics  research experimental subject
MpE(z)1 (Enhancer of zeste homolog) is the catalytic PRC2 subunit; the Mpknox2 Mpe(z)1 double mutant with reduced PRC2 activity was analysed by ChIP, showing depletion of H3K27me3 at facultative-heterochromatin states while H2Aub was retained.
Hisanaga, T., et al. (2023a) · Current Biology  research experimental subject
E(z)/EZH PRC2 catalytic subunit (MpE(z)1, Mp5g18040); the only E(z) paralog expressed in vegetative gametophyte; knockout shows PRC2 deposits H3K27me3 and represses TEs and developmental genes.
Montgomery, S. A., et al. (2022) · eLife  research experimental comparator
Expressed in all tissues including embryos; not functionally knocked out due to haploid lethality, so likely accounts for residual H3K27me3 in e(z)2/e(z)3 mutants, indicating redundancy among PRC2 catalytic subunits.
Dierschke, T., et al. (2021) · eLife  research experimental tool
Used as a knockdown transgene/experimental construct serving as a comparison control rather than a focus of study.

Transcript models

Transcript ID Location Sequences Extract region
Mp5g18040.1 chr5:22261104..22271641 (+) Gene /  mRNA /  CDS /  Protein
FASTA / GenBank (with flanking bases)

Expression Level powered by MBEX

Link to the original image in MBEX

Single-cell expression scRNA-seq atlas from Wang et al., 2023

Expression of Mp5g18040 across the single-cell RNA-seq atlas. Cluster identities (right) annotate the same UMAP used for the feature plot (left).

Feature plot of Mp5g18040 on UMAP
Feature plot (Seurat scale expression level).
UMAP cluster annotation
Cell-type annotation of the UMAP clusters.
Violin plot by developmental stage
Violin plot by stage. Expression across developmental time points (D0–D31).
Violin plot by cell cluster
Violin plot by cluster. Expression across cell clusters (1–21).

Gene structure:

Sequences:

Gene UTR + CDS + intron

FASTA

mRNA UTR + CDS

FASTA

CDS

FASTA

Protein

FASTA

MarpolBase / Genome Informatics Lab. NIG.