Mp4g02270



Description

Annotation

Database ID Description
CDD cd05312 NAD_bind_1_malic_enz
Coils Coil Coil
FunFam G3DSA:3.40.50.10380:FF:000005 Malic enzyme
FunFam G3DSA:3.40.50.720:FF:000237 Malic enzyme
Gene3D G3DSA:3.40.50.10380 -
Gene3D G3DSA:3.40.50.720 -
KEGG K00028 malate dehydrogenase (decarboxylating) [EC:1.1.1.39]
KEGG K00029 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40]
KOG KOG1257 NADP+-dependent malic enzyme; [C]
PANTHER PTHR23406 MALIC ENZYME-RELATED
PIRSF PIRSF000106 ME
PRINTS PR00072 Malic enzyme signature
Pfam PF00390 Malic enzyme, N-terminal domain
Pfam PF03949 Malic enzyme, NAD binding domain
ProSitePatterns PS00331 Malic enzymes signature.
SMART SM00919 Malic_M_2
SMART SM01274 malic_2
SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains
SUPERFAMILY SSF53223 Aminoacid dehydrogenase-like, N-terminal domain
GO GO:0006108 malate metabolic process
GO GO:0051287 NAD binding
GO GO:0005739 mitochondrion
GO GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO GO:0006090 pyruvate metabolic process
GO GO:0004470 malic enzyme activity
GO GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
MapolyID Mapoly0080s0072 -

Nomenclature

No gene symbols are registered for this gene.

Associated Literature (AI-based literature mining)

The MpMME1 malic enzyme homolog was amplified from Marchantia cDNA, fused to a fluorescent reporter and expressed in Marchantia to test targeting. Its mitochondrial targeting peptide normally directs it to mitochondria; when the positively charged residues of the mTP were substituted with serines the construct instead predominantly targeted plastids, showing that charge divergence in the targeting sequence determines organellar specificity.

1 core 0 peripheral

Raval PK, García García C, Sanchez MS, Gould SB. (2025) · Molecular biology and evolution  research experimental subject
The MpMME1 malic enzyme homolog was amplified from Marchantia cDNA, fused to a fluorescent reporter and expressed in Marchantia to test targeting. Its mitochondrial targeting peptide normally directs it to mitochondria; when the positively charged residues of the mTP were substituted with serines the construct instead predominantly targeted plastids, showing that charge divergence in the targeting sequence determines organellar specificity.

Transcript models

Transcript ID Location Sequences Extract region
Mp4g02270.2 chr4:2867556..2875126 (-) Gene /  mRNA /  CDS /  Protein
FASTA / GenBank (with flanking bases)
Mp4g02270.1 chr4:2867603..2876314 (-) Gene /  mRNA /  CDS /  Protein
FASTA / GenBank (with flanking bases)

Expression Level powered by MBEX

Link to the original image in MBEX

Single-cell expression scRNA-seq atlas from Wang et al., 2023

Expression of Mp4g02270 across the single-cell RNA-seq atlas. Cluster identities (right) annotate the same UMAP used for the feature plot (left).

Feature plot of Mp4g02270 on UMAP
Feature plot (Seurat scale expression level).
UMAP cluster annotation
Cell-type annotation of the UMAP clusters.
Violin plot by developmental stage
Violin plot by stage. Expression across developmental time points (D0–D31).
Violin plot by cell cluster
Violin plot by cluster. Expression across cell clusters (1–21).

Gene structure:

Sequences:

Gene UTR + CDS + intron

FASTA

mRNA UTR + CDS

FASTA

CDS

FASTA

Protein

FASTA

Gene structure:

Sequences:

Gene UTR + CDS + intron

FASTA

mRNA UTR + CDS

FASTA

CDS

FASTA

Protein

FASTA


MarpolBase / Genome Informatics Lab. NIG.