Mp2g24850



Description

Annotation

Database ID Description
Gene3D G3DSA:3.30.470.20 -
ProSiteProfiles PS50975 ATP-grasp fold profile.
PANTHER PTHR14217 INOSITOL-TETRAKISPHOSPHATE 1-KINASE
FunFam G3DSA:3.30.470.20:FF:000056 Inositol-tetrakisphosphate 1-kinase
Pfam PF17927 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain
Pfam PF05770 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain
SUPERFAMILY SSF56059 Glutathione synthetase ATP-binding domain-like
PIRSF PIRSF038186 ITPK
KEGG K00913 inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase [EC:2.7.1.159 2.7.1.134]
MapolyID Mapoly0181s0012 -
GO GO:0000287 magnesium ion binding
GO GO:0032957 inositol trisphosphate metabolic process
GO GO:0046872 metal ion binding
GO GO:0005524 ATP binding
GO GO:0052726 inositol-1,3,4-trisphosphate 5-kinase activity
GO GO:0052725 inositol-1,3,4-trisphosphate 6-kinase activity
GO GO:0052746 obsolete inositol phosphorylation
GO GO:0005737 cytoplasm
GO GO:0047325 inositol-3,4,5,6-tetrakisphosphate 1-kinase activity

Nomenclature

Gene symbol Product Transcript ID Status
MpITPK1 inositol phosphate kinase Published

Associated Literature (AI-based literature mining, Beta-version)

Overexpression in Marchantia raised 5-InsP7 and InsP8 and weakened the Pi-starvation response (fewer/shorter rhizoids, lower PSI gene expression); MpITPK1 also complemented the Arabidopsis atitpk1-2 mutant. Identified as a kinase controlling Pi-responsive PP-InsP signaling.

2 core 2 peripheral

Pullagurla, N. J., et al. (2025) · Plant Physiology  research experimental subject
ITPK1-type inositol phosphate kinase (Mp2g24850); orchestrates phosphate homeostasis in M. polymorpha, producing inositol pyrophosphates that regulate the PSI response.
Chen, J., et al. (2024) · Plant Physiology  research experimental subject
Overexpression in Marchantia raised 5-InsP7 and InsP8 and weakened the Pi-starvation response (fewer/shorter rhizoids, lower PSI gene expression); MpITPK1 also complemented the Arabidopsis atitpk1-2 mutant. Identified as a kinase controlling Pi-responsive PP-InsP signaling.
Ghosh R, Yadav R, Pullagurla NJ, Rana P, Laha D. (2025) · FEBS letters  review citation background
Reviewed: overexpression of MpITPK1 elevates 5-InsP7 and an InsP8 isomer in M. polymorpha inositol phosphate metabolism.
Laurent, F., et al. (2025) · PLoS Genetics  research sequence background
A PP-InsP biosynthetic enzyme whose transcript was quantified by RNA-seq; no loss-of-function mutant generated.

Transcript models

Transcript ID Location Sequences Extract region
Mp2g24850.1 chr2:30302560..30306270 (-) Gene /  mRNA /  CDS /  Protein
FASTA / GenBank (with flanking bases)

Expression Level powered by MBEX

Link to the original image in MBEX

Single-cell expression scRNA-seq atlas from Wang et al., 2023

Expression of Mp2g24850 across the single-cell RNA-seq atlas. Cluster identities (right) annotate the same UMAP used for the feature plot (left).

Feature plot of Mp2g24850 on UMAP
Feature plot (Seurat scale expression level).
UMAP cluster annotation
Cell-type annotation of the UMAP clusters.
Violin plot by developmental stage
Violin plot by stage. Expression across developmental time points (D0–D31).
Violin plot by cell cluster
Violin plot by cluster. Expression across cell clusters (1–21).

Gene structure:

Sequences:

Gene UTR + CDS + intron

FASTA

mRNA UTR + CDS

FASTA

CDS

FASTA

Protein

FASTA

MarpolBase / Genome Informatics Lab. NIG.