Mp5g06690
Description
Annotation
| Database | ID | Description |
|---|---|---|
| FunFam | G3DSA:1.20.1530.20:FF:000009 | Arsenite transporter, ACR3 family |
| Gene3D | G3DSA:1.20.1530.20 | - |
| KEGG | K03325 | arsenite transporter |
| NCBIfam | TIGR00832 | ACR3 family arsenite efflux transporter |
| PANTHER | PTHR43057 | ARSENITE EFFLUX TRANSPORTER |
| Pfam | PF01758 | Sodium Bile acid symporter family |
| GO | GO:0015104 | antimonite transmembrane transporter activity |
| GO | GO:0015700 | arsenite transport |
| GO | GO:0015103 | inorganic anion transmembrane transporter activity |
| GO | GO:0005886 | plasma membrane |
| GO | GO:0015105 | arsenite transmembrane transporter activity |
| GO | GO:0015297 | antiporter activity |
| GO | GO:0016020 | membrane |
| GO | GO:0015699 | antimonite transmembrane transport |
| MapolyID | Mapoly0171s0014 | - |
Nomenclature
| Gene symbol | Product | Transcript ID | Status |
|---|---|---|---|
| MpACR3 | arsenite efflux transporter ACR3 | Published |
Associated Literature (AI-based literature mining)
Sole M. polymorpha ACR3 arsenite [As(III)] efflux transporter, whose arsenic-responsive cysteine-rich N-terminal domain controls its trafficking: it sits in Golgi bodies and the plasma membrane under non-stress conditions, while As(III) binding stabilises the N-terminus and drives relocalisation to the plasma membrane. A di-arginine LRCRF motif is required for intracellular retention (Leu, Arg) and for As(III)-induced relocalisation (Cys, Phe). ID NOTE: the paper states no v7.1 locus and the symbol is not yet registered.
2 core 0 peripheral
Bonter I, Mizio K, Dolzblasz A, Tomaszewska P, Zbieralski K, Staszewski J, Wawrzycka D, Reymer A, Bialek W, Kriechbaumer V, Haseloff J, Wysocki R, Maciaszczyk-Dziubinska E. (2026)
· Plant Cell research experimental subject
Sole M. polymorpha ACR3 arsenite [As(III)] efflux transporter, whose arsenic-responsive cysteine-rich N-terminal domain controls its trafficking: it sits in Golgi bodies and the plasma membrane under non-stress conditions, while As(III) binding stabilises the N-terminus and drives relocalisation to the plasma membrane. A di-arginine LRCRF motif is required for intracellular retention (Leu, Arg) and for As(III)-induced relocalisation (Cys, Phe). ID NOTE: the paper states no v7.1 locus and the symbol is not yet registered.
Li, M., et al. (2024a)
· Journal of Hazardous Materials research experimental subject
Arsenite efflux transporter (ACR3-type; Mp5g06690); knockout and overexpression lines show it plays a pivotal role in arsenic detoxification in M. polymorpha.
Single-cell expression scRNA-seq atlas from Wang et al., 2023
Expression of Mp5g06690 across the single-cell RNA-seq atlas. Cluster identities (right) annotate the same UMAP used for the feature plot (left).
Gene structure:
Sequences: |
Gene UTR + CDS + intron |
| >Mp5g06690.1 CGGGGGAAAC GAGTGACTGT TGGGCGACAG AGGCCACTGT TCTGGCTAAT CATCAGGAGG ACAGCTCCGC CCGGGGGCAC GATGGGCCAG ATTGGGTCGG CCTGTAGCCT CTGAGTCTGT TGTGCTCGTT GTCGTTGGGC TCGAGCAGCA GCAGCAGAAC TGTTCGGCCC ATGAGATGCA GGAGAGAAGA GCACTCGCAG GGCTCGCTTT TTAATTGTAC CTTGGTGCAT TCAGCAACTT CATCCCATTC GCTCGAGCTC GGTCTGCTTG TCAAGGTGAT TTCTGCATTC TTCTCATGGT TCGAATTTCT AGAGACCAGT GAATGGAGGT CTGTCTGTGT CTATCACGAT GCTGGATCGT CGTTCTCTTG CGTTCATGTC CGGGCTTTTC ATCGCAGTGG CCGACGGCAC GCAGGACGAT GCAGAGTAGG AAAAATTGGG TCGTGGGTTT CGTTCTGTAG GAGCGAAAGA CTGGGCCTGG ATTTTTTTTT GGTCGATGAA AGGAGATGGT GAAAATCGGT CGCGGTCTTT GGATGACTTC TAACCTCGTT TTTAATTTTT TTAATTTTTT TTTTTATTGC GGGAGACTTC GTATGAGGGT ACGAATATAT TTCTCATATT ATTTGAAACG GGAATCCGTC ACAATGGCCG ATATGCATCA TCTATGCACT GCGAATCTCT CTCTAGTTGG ATATATGGCC GCAAGGCATA TGCTGACTCG ATGAGCCTCA GGCCCTGAAC AAGCCAATTT CGAGTCAAGC TCTGTGTTTG TCGTAACGAC TGGGGATTGT TGAGCTCGTC GTCATACCTA TCATCCGAAA TGAACATGTC TTTTGTCCGT CTTTCCACCA GCCATTGGTA ATCATAACTT CCTGCGGACC TACGGGTGTC TTTATCGTCG CCTTGGTTTA CCAATTTGAT CTCAAGAGAG ATAGACGATT CGACAAAAGC CCAGCACACC TGGGAGTAGA TCTGATGACT TTGAAGGGAT GGTGGTAGGG AGGAAGCTCG AGGTTTTTAG CGGAGGGAGC TGTTTGTTGA TGTTTGTAAT TGTTGCTTGC TTGCAGAAGT GGGTCTTCGA CGTGAAGTAC AATGAGGGGC TCGGAGATGA CTGAGATGGA GGCAGAGAGA CCAGTGGATA ATACAGGTCT AGAAGCTGGT GAAGTTGTTG TGAAGTGTAA GCCCTTGTGG GACGATGCGA GAACAGGGAG CGCGAAGGAT GAGTTGAGGT GTCGGTTCTC CAAGGAATCG AGGAATGTTG ATGTTCCTGT TGTTGACGGA GACAATGCTG AAGGGTTTCT GTGTAAATGT AGTGCCGAGG TAAGGCGACG CCCAATCTCA TGGCACCGTT GAGTTTGTAG TGAGTTTTAT GCTTTACTAG ATGGACGCAT ATGGTTCCCT CTGTTCCCTG ACCGTAATTG TTTGCTCCTG CTTTTCGTCA GCTTTCCTCC ACTGGTACCA CTGTATCCAT CCTTCTTCCA AATGGCGATG AGCTCTCGTG TGAAGCCCTA CCGGACTCGG ACAAGGTCAA GGGCGTGGTT ACAGGTAATT TTAGCTTTTG AGGTGACAGT TCGTACGTCA GTCAATCACT TGTGCCCTTC AATATGCTGA TCTGTAAATT GTTGCTTTAG TTTCAGTCAG GAATTATTGT CCGCATCTCA ATTTTTTACT GTGGAAGTTC TGTTGATTTG AGAGGAAGGC TCTGTTTGTC AATTCGAGGT CAATATTTCT GACGATTATT TGGATGATCT GACGAGGAGT TTTTCTGTTC TTTCCCACCA GCTGGTCAAA TCTACAAACA GCTCTCATTA CTGGACAGAT ATCTCTTCGT CTGGATCTTC GCTGTGATGG GTCTAGCTCT CCTGATAGGT TACTACGTAG ACGGGATCAA GAAACGCCTG TCGGTGGTGG AAATAGCCTC AGTATCGTTG CCAATTGCTA TCGGACTGTG GGTGATGATG TACCCGGTAC TCTGCAAGGT ACGCTACGAG CTGCTGTACA AGATGCTCAG ACGCGGTCGC CTGGGTAAGA ACCTGGCCAT CAGCCTCGTG CTAAATTGGC TCGTCGGCCC TGCTCTTATG ACAGGACTAG CCTGGGCTAC TCTACCAGAC CTGTCGGATT ACAGAACTGG TGTTATTTTG GTGGGAATCG CTCGCTGCAT TGCCATGGTA CTTATCTGGA ACGAGCTGGC CAAAGGAGAT GCTCAACTTT GTGCCATCAT AGTAGCTGTG AACTCCGTTC TTCAGATTAT TCTTTTCACT CCCGTCTCTC TATTCTATCT GAAGGTCATA TCCGGAGGTA AGGGAATTGA TGTGGGTGTT TGGACCGTGG CCAAATCTGT GCTCTTGTTT CTCGGTGTTC CTCTTCTAGC GGGCTTTTTG ACAAGGGTGA TTTTGAGAAG AGCAGCGGGA GCCAGATGGT ACGATACCAA ATTCCTCCCG TTCATCGGGC CTTGGGCTCT TCTGGGATTG CTATACACAA TATTCGTCAT GTTTGCGATT CAGTCTCATG AAATCGTGAA CAACATTGGA CACGTGCTTC GTGTGGTGGT GCCCTTGCTG CTTTACTTCT CCATCACTTT CACATCAGCT GTGGCAGTGT GCCGGTACTT CAATTTGCCA TACCCTGAGA TTGTGACACA ATCCTTCACT GCAGCCAGTA ACAACTTTGA GCTGGCCATA GCTGTGGCTG TTGGAGCTTT CGGCATCGAT TCACATGAAG CGCTGGCCGC CACTATCGGG CCTCTCATCG AGGTTCCCGT TCTATTGATC CTGGTCTACG TTACATTGTA TTTCAGGAAA TGGCTCTCAA AAGAACAAGC TTAGGATAAT AAAATATACT CGTATACTTT CTATTGGAGT CCGTGAGCTT CCTCTTTGGC AGTATCAGAA GGACATTCCA GAGTTGTCGT CACATTTTTG GGGCTTGTCG GTATCTCTGG TCTTCGCGAG AATTGTTGTG TTTATTCACG TCGAGACCTC ACACACCTGG AAATCTGAGG AGAGTGGCAA TGATTCGTGG GAGTGATCTG TCAATTCCTC GTGTGTTCAG TCTTGGATCT CATGGATCAA GGAGTCTAGT ATTTACTTTG TCAACTCATA TTTTCCTGTC TGGTAGCGTC TTACATGGCT TCGAAAGCAT GACACCGCTG TCAACGAAAA TCTTGTCGTA GATGTCGCCT TAGAGAGGAA AAATTGTGGT TATGGGTGCG TAGATTATAA TAAAATTCCA CTGCACTTGC TTCCGCAGAT GTGAAAAGGG AAAGCTCACG TTGAAATGCA AGCAGAAGGT CAGAGATATT GTCTGTAGAT ATTAACTCTA ATTGCAGCTT TGCGAAATGG AGGAAG |
mRNA UTR + CDS |
| >Mp5g06690.1 CGGGGGAAAC GAGTGACTGT TGGGCGACAG AGGCCACTGT TCTGGCTAAT CATCAGGAGG ACAGCTCCGC CCGGGGGCAC GATGGGCCAG ATTGGGTCGG CCTGTAGCCT CTGAGTCTGT TGTGCTCGTT GTCGTTGGGC TCGAGCAGCA GCAGCAGAAC TGTTCGGCCC ATGAGATGCA GGAGAGAAGA GCACTCGCAG GGCTCGCTTT TTAATTGTAC CTTGGTGCAT TCAGCAACTT CATCCCATTC GCTCGAGCTC GGTCTGCTTG TCAAGAAGTG GGTCTTCGAC GTGAAGTACA ATGAGGGGCT CGGAGATGAC TGAGATGGAG GCAGAGAGAC CAGTGGATAA TACAGGTCTA GAAGCTGGTG AAGTTGTTGT GAAGTGTAAG CCCTTGTGGG ACGATGCGAG AACAGGGAGC GCGAAGGATG AGTTGAGGTG TCGGTTCTCC AAGGAATCGA GGAATGTTGA TGTTCCTGTT GTTGACGGAG ACAATGCTGA AGGGTTTCTG TGTAAATGTA GTGCCGAGCT TTCCTCCACT GGTACCACTG TATCCATCCT TCTTCCAAAT GGCGATGAGC TCTCGTGTGA AGCCCTACCG GACTCGGACA AGGTCAAGGG CGTGGTTACA GCTGGTCAAA TCTACAAACA GCTCTCATTA CTGGACAGAT ATCTCTTCGT CTGGATCTTC GCTGTGATGG GTCTAGCTCT CCTGATAGGT TACTACGTAG ACGGGATCAA GAAACGCCTG TCGGTGGTGG AAATAGCCTC AGTATCGTTG CCAATTGCTA TCGGACTGTG GGTGATGATG TACCCGGTAC TCTGCAAGGT ACGCTACGAG CTGCTGTACA AGATGCTCAG ACGCGGTCGC CTGGGTAAGA ACCTGGCCAT CAGCCTCGTG CTAAATTGGC TCGTCGGCCC TGCTCTTATG ACAGGACTAG CCTGGGCTAC TCTACCAGAC CTGTCGGATT ACAGAACTGG TGTTATTTTG GTGGGAATCG CTCGCTGCAT TGCCATGGTA CTTATCTGGA ACGAGCTGGC CAAAGGAGAT GCTCAACTTT GTGCCATCAT AGTAGCTGTG AACTCCGTTC TTCAGATTAT TCTTTTCACT CCCGTCTCTC TATTCTATCT GAAGGTCATA TCCGGAGGTA AGGGAATTGA TGTGGGTGTT TGGACCGTGG CCAAATCTGT GCTCTTGTTT CTCGGTGTTC CTCTTCTAGC GGGCTTTTTG ACAAGGGTGA TTTTGAGAAG AGCAGCGGGA GCCAGATGGT ACGATACCAA ATTCCTCCCG TTCATCGGGC CTTGGGCTCT TCTGGGATTG CTATACACAA TATTCGTCAT GTTTGCGATT CAGTCTCATG AAATCGTGAA CAACATTGGA CACGTGCTTC GTGTGGTGGT GCCCTTGCTG CTTTACTTCT CCATCACTTT CACATCAGCT GTGGCAGTGT GCCGGTACTT CAATTTGCCA TACCCTGAGA TTGTGACACA ATCCTTCACT GCAGCCAGTA ACAACTTTGA GCTGGCCATA GCTGTGGCTG TTGGAGCTTT CGGCATCGAT TCACATGAAG CGCTGGCCGC CACTATCGGG CCTCTCATCG AGGTTCCCGT TCTATTGATC CTGGTCTACG TTACATTGTA TTTCAGGAAA TGGCTCTCAA AAGAACAAGC TTAGGATAAT AAAATATACT CGTATACTTT CTATTGGAGT CCGTGAGCTT CCTCTTTGGC AGTATCAGAA GGACATTCCA GAGTTGTCGT CACATTTTTG GGGCTTGTCG GTATCTCTGG TCTTCGCGAG AATTGTTGTG TTTATTCACG TCGAGACCTC ACACACCTGG AAATCTGAGG AGAGTGGCAA TGATTCGTGG GAGTGATCTG TCAATTCCTC GTGTGTTCAG TCTTGGATCT CATGGATCAA GGAGTCTAGT ATTTACTTTG TCAACTCATA TTTTCCTGTC TGGTAGCGTC TTACATGGCT TCGAAAGCAT GACACCGCTG TCAACGAAAA TCTTGTCGTA GATGTCGCCT TAGAGAGGAA AAATTGTGGT TATGGGTGCG TAGATTATAA TAAAATTCCA CTGCACTTGC TTCCGCAGAT GTGAAAAGGG AAAGCTCACG TTGAAATGCA AGCAGAAGGT CAGAGATATT GTCTGTAGAT ATTAACTCTA ATTGCAGCTT TGCGAAATGG AGGAAG |
CDS |
| >Mp5g06690.1 ATGAGGGGCT CGGAGATGAC TGAGATGGAG GCAGAGAGAC CAGTGGATAA TACAGGTCTA GAAGCTGGTG AAGTTGTTGT GAAGTGTAAG CCCTTGTGGG ACGATGCGAG AACAGGGAGC GCGAAGGATG AGTTGAGGTG TCGGTTCTCC AAGGAATCGA GGAATGTTGA TGTTCCTGTT GTTGACGGAG ACAATGCTGA AGGGTTTCTG TGTAAATGTA GTGCCGAGCT TTCCTCCACT GGTACCACTG TATCCATCCT TCTTCCAAAT GGCGATGAGC TCTCGTGTGA AGCCCTACCG GACTCGGACA AGGTCAAGGG CGTGGTTACA GCTGGTCAAA TCTACAAACA GCTCTCATTA CTGGACAGAT ATCTCTTCGT CTGGATCTTC GCTGTGATGG GTCTAGCTCT CCTGATAGGT TACTACGTAG ACGGGATCAA GAAACGCCTG TCGGTGGTGG AAATAGCCTC AGTATCGTTG CCAATTGCTA TCGGACTGTG GGTGATGATG TACCCGGTAC TCTGCAAGGT ACGCTACGAG CTGCTGTACA AGATGCTCAG ACGCGGTCGC CTGGGTAAGA ACCTGGCCAT CAGCCTCGTG CTAAATTGGC TCGTCGGCCC TGCTCTTATG ACAGGACTAG CCTGGGCTAC TCTACCAGAC CTGTCGGATT ACAGAACTGG TGTTATTTTG GTGGGAATCG CTCGCTGCAT TGCCATGGTA CTTATCTGGA ACGAGCTGGC CAAAGGAGAT GCTCAACTTT GTGCCATCAT AGTAGCTGTG AACTCCGTTC TTCAGATTAT TCTTTTCACT CCCGTCTCTC TATTCTATCT GAAGGTCATA TCCGGAGGTA AGGGAATTGA TGTGGGTGTT TGGACCGTGG CCAAATCTGT GCTCTTGTTT CTCGGTGTTC CTCTTCTAGC GGGCTTTTTG ACAAGGGTGA TTTTGAGAAG AGCAGCGGGA GCCAGATGGT ACGATACCAA ATTCCTCCCG TTCATCGGGC CTTGGGCTCT TCTGGGATTG CTATACACAA TATTCGTCAT GTTTGCGATT CAGTCTCATG AAATCGTGAA CAACATTGGA CACGTGCTTC GTGTGGTGGT GCCCTTGCTG CTTTACTTCT CCATCACTTT CACATCAGCT GTGGCAGTGT GCCGGTACTT CAATTTGCCA TACCCTGAGA TTGTGACACA ATCCTTCACT GCAGCCAGTA ACAACTTTGA GCTGGCCATA GCTGTGGCTG TTGGAGCTTT CGGCATCGAT TCACATGAAG CGCTGGCCGC CACTATCGGG CCTCTCATCG AGGTTCCCGT TCTATTGATC CTGGTCTACG TTACATTGTA TTTCAGGAAA TGGCTCTCAA AAGAACAAGC TTAG |
Protein |
| >Mp5g06690.1 MRGSEMTEME AERPVDNTGL EAGEVVVKCK PLWDDARTGS AKDELRCRFS KESRNVDVPV VDGDNAEGFL CKCSAELSST GTTVSILLPN GDELSCEALP DSDKVKGVVT AGQIYKQLSL LDRYLFVWIF AVMGLALLIG YYVDGIKKRL SVVEIASVSL PIAIGLWVMM YPVLCKVRYE LLYKMLRRGR LGKNLAISLV LNWLVGPALM TGLAWATLPD LSDYRTGVIL VGIARCIAMV LIWNELAKGD AQLCAIIVAV NSVLQIILFT PVSLFYLKVI SGGKGIDVGV WTVAKSVLLF LGVPLLAGFL TRVILRRAAG ARWYDTKFLP FIGPWALLGL LYTIFVMFAI QSHEIVNNIG HVLRVVVPLL LYFSITFTSA VAVCRYFNLP YPEIVTQSFT AASNNFELAI AVAVGAFGID SHEALAATIG PLIEVPVLLI LVYVTLYFRK WLSKEQA |