Mp6g00020
Description
Annotation
| Database | ID | Description |
|---|---|---|
| FunFam | G3DSA:1.10.630.10:FF:000013 | Trans-cinnamate 4-monooxygenase |
| Gene3D | G3DSA:1.10.630.10 | Cytochrome P450 |
| KEGG | K00487 | trans-cinnamate 4-monooxygenase [EC:1.14.14.91] |
| KOG | KOG0156 | Cytochrome P450 CYP2 subfamily; [Q] |
| PANTHER | PTHR47948 | TRANS-CINNAMATE 4-MONOOXYGENASE |
| PRINTS | PR00385 | P450 superfamily signature |
| PRINTS | PR00463 | E-class P450 group I signature |
| Pfam | PF00067 | Cytochrome P450 |
| ProSitePatterns | PS00086 | Cytochrome P450 cysteine heme-iron ligand signature. |
| SUPERFAMILY | SSF48264 | Cytochrome P450 |
| GO | GO:0005506 | iron ion binding |
| GO | GO:0016705 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| GO | GO:0004497 | monooxygenase activity |
| GO | GO:0020037 | heme binding |
| MapolyID | Mapoly0163s0018 | - |
Nomenclature
| Gene symbol | Product | Transcript ID | Status |
|---|---|---|---|
| MpC4H1 | Cytochrome P450, Secondary metabolism enzyme | Provisional |
Associated Literature (AI-based literature mining)
Primary, most highly expressed CYP73A paralog in M. polymorpha; encoded protein shows C4H activity in vitro. CRISPR mutants display dramatically reduced thallus area and fewer gemmae cups, with ~50% drop in two essential phenylpropanoid pathway intermediates.
3 core 4 peripheral
Aggarwal-Kentrath CEG, Petersen M. (2026)
· Plant J research experimental subject
CYP73 cinnamate 4-hydroxylase confirmed by heterologous expression to 4-hydroxylate trans-cinnamate. MpC4H1 is the most highly expressed of the three isoforms, especially in thalli, antheridiophores and archegoniophores.
Knosp, S., et al. (2024)
· The EMBO Journal research experimental subject
Primary, most highly expressed CYP73A paralog in M. polymorpha; encoded protein shows C4H activity in vitro. CRISPR mutants display dramatically reduced thallus area and fewer gemmae cups, with ~50% drop in two essential phenylpropanoid pathway intermediates.
Liu, X.-Y., et al. (2017)
· Plant Physiology and Biochemistry research experimental subject
Cinnamate 4-hydroxylase (C4H) of M. polymorpha; isolated and functionally characterized, with higher catalytic activity, in a phenylpropanoid-entry study across liverworts.
Zhou Y, Hamiaux C, Andre CM, Cooney JM, Schwinn KE, van Klink JW, Bowman JL, Davies KM, Albert NW. (2025)
· The New phytologist research experimental background
Highest-abundance C4H, transcript level unchanged in Mppr10.5.
Carella, P., et al. (2024)
· Current Biology research experimental background
Cinnamate-4-hydroxylase; MpMYB14-regulated defense DEG.
Single-cell expression scRNA-seq atlas from Wang et al., 2023
Expression of Mp6g00020 across the single-cell RNA-seq atlas. Cluster identities (right) annotate the same UMAP used for the feature plot (left).
Gene structure:
Sequences: |
Gene UTR + CDS + intron |
| >Mp6g00020.1 AGTTTTCGAG CACCACTGTC CTCCCGTTCC CTCCATTCCT CTTGTGGCTC CTGACGGGGA AGAGAGCACA CGCGCGTTCT CTTCTTCCCT TGCGCCTTGT AAAATCGAAC GAAGCATAGC ACAATTCCTT TCTGTCTTGG GCAGAATGTG GGGTGAGAGA GCAGCCATGG CGCTGTGCCT CGCGGCAGGA GGGTTGAGTG GAGTTCTCGC GGAGGCCGAT GATGCAACCA TCACAGCTTC AAGCAGCAGC ATGTTCACCC TGCAGAATGT GCTGTTCGGC CTGCTAGCTG CCACGTTGGG ACTGATTCTG CTGTTGAATC TGAAAGGGAA GAAGCTAAAA TTGCCTCCCG GCCCTCCCGG CATTCCCATT TTCGGCAATT GGCTTCAAAT TGGAGATGAT CTAAATCACC GAAATTTGGC TGAGTTGGCC AAAAAGTATG GAGAAGTGTG CATGCTGAAG ATGGGCCAGA GAAATTACGT CATTGTGTCT AGCCCTGAAG TTGCCAAGGA GGTTCTTCAC ACCCAGGGCG TGGAATTTGG ATCCCGCACC AGAAATGTTG TTTTCGACAT CTTTACAGGA AATGGACAGG ATATGGTGTT CACAGTCTAT GGAGAGCACT GGAGGAGAAT GAGGAGGATC ATGACTGTTC CCTTCTTCAC CAACAAGGTG GTCATGCAGT CTCGATTCGC CTGGGAGGAC GAAATCAATC ATGTTATCAA GGACCTGACC GCTAGTAAGG AGGCCTCTAC CACCGGTGTG ATCATAAGAA GAAGGCTGCA GCTCATGATG TACAATGTTA TGTATCGCAT GATGTTCGAC AGAAGGTTTG AGACAGTGGA CGATCCCCTA TTCGTCAAGC TGAAGGCCGT GAACGGAGAG AGGAGTCGCC TAGCTCAAAG CTTTGAATAC AACTACGGTG ATTTTATCCC CATCTTGAGA CCATTCCTTC GAAAGTATCT TGCCTATTGC CAGCAGCTGA AGGACAAGAG GCTGGCCCTG TTCAAGGAAT ATTTCGTCGA AGAGCGCAAG TATGTTTCAC AAACTCTTAT CCGTACCCAC CATCAGAGTC CTTCTTTGGG TATATTTTAA GTTGCAGCCA TGTCCAGTTG TCTTCAGGGC ACCCATCGTG TCCTTAAATC GACCATATGG TAGCGCTATT ATCTAGCTTA AGAATCGATG TCACCTACGC CTGTGTTAAG GTGCCATGCA GTTCTTCAGT CCTAGTCAAA TTCTGTTTTT GGTGTTGAGC CTGCTTCTGT CTATCTAGGA ACCTTAAATT GTCATTGTGT CGAATGCCTC TCACCACAAA GTTTATGTAC TCATGCGATT CTGTCTAAGT AAGTATTGGC TTCTGCTGGT GGACTAGTCG GGGTCTTAGC ATAAAGTCAG GTTATGTTCT CTAACTACTA TACTGAAAGT TGCTGCCATG TTTATTGAGT ACAGAAAGGT ATTGAGCACA CGAGGATCAG GCGGTGGCGA GAAAGCAGCT ATTGATTACA TTTTTGAATC CGAGCAAAAG GGAGAGATAA ATGAAGATAA TGTATTGTAT ATCGTCGAGA ACATCAATGT TGCTGGTAAG GACCGAATCA GTCTAGCAAG ACGAGTCGCA AGAACTGTAT TTGTCGTCAA TCCTTTGTTT CCAGGATGAC CATGGCCGTT TTCCAGCTGC ACAACGAAAG AAGGTGCTGA GTAGCTATCA CAATACGCGT GTATTTGTAG TCTCCAACTT TGCATGTTCT AAATCCTTGT TCAATCGTGG TGCTCATTCT TGCAGCTATT GAGACTACCT TGTGGTCCAT CGAGTGGGGA GTGGCTGAGC TGTGCAACAA CCCTGACATT TTCAAGAAAT TAAGGAATGA GTTGGATTCT ATCCTCGGTC GTGGACACTT GGTCTCCGAG CCCGATCTCC CTCAACTGCC GTACCTCGGC TCTGTGGTGA AAGAAGTCAT GCGACTACAC ATGGCCATTC CCCTTCTTGT GCCCCACATG AATCTACATC AAGCTAAGCT TGCAGGTTAT GATATACCAG CAGAGAGCAA AATTCTCGTC AACGCATGGT GGATAGCAAA CAACCCCGAA CACTGGGTTG AACCTGAGAA ATTCAACCCT GAGCGCTTCA TGGATGGCAA AATCGAATCC AGCGGGAATG ATTTTCGCTT CCTTCCTTTC GGATCTGGGC GCAGAAGCTG TCCGGGTATC ATCATCGCCA TTCCGCTGTT GTCCTTGGTC CTAGGTCGGC TTGTCCAGTC ATTTGACTTG TATCCACCTC CAGGGGTTGA TAAGATTGAT ATGACGGAGA AAGGAGGACA ATTCAGTCTT TTCATCAAGA CTCATTACAA CATGGTTGTT AAACCGAGGG CTGATTGAAG CAAGTATAGA GCTCACCAAG AATAGAAACT GATGATGACT AGAATATAGA ACAATCAGGA AGCAGAACTT CTCAACCGAC CTGAAGCTGT ATAGTTGTGC TGGGGATCTT AGGTGGTGAT CTGTTTCTTG AATGGAGGAG TTATCAGAAT AGACACGACC CTCCAAGTAT CTCCTTTTGT GAAAAGTAGG CACAGTAGAG TCTAGACGAA CTAATTAGAA AAGAACCTTC AGTAAGGAGG AATAACGTCT TCCGTTTTCA ACTCGATTTT TTTTGTCGAA GGTCTATAGC TGTAGCATCC TGCAAAGGGT TCGCTTTCCC CTCCCCCTCC TCAACATCTG GTCTGGCTGC CAATTGCTGC TAGGGTTGAG TAGATTGAAA ATAATCTATA CCTGTCCGCC GTTCACTCTA CTGCAAGCGT TGCTTTCGAG GCTTTTTCTA GCGTACTTAT CGTATTTTCA TGATCTTTGC GTGTTGAAAA TTTTCTCTGC TCCGTTCCGT TCCGTTCACG ATATGTTTTT GTCGAATTTC GCAATCCGTA GATCTGAATT GCG |
mRNA UTR + CDS |
| >Mp6g00020.1 AGTTTTCGAG CACCACTGTC CTCCCGTTCC CTCCATTCCT CTTGTGGCTC CTGACGGGGA AGAGAGCACA CGCGCGTTCT CTTCTTCCCT TGCGCCTTGT AAAATCGAAC GAAGCATAGC ACAATTCCTT TCTGTCTTGG GCAGAATGTG GGGTGAGAGA GCAGCCATGG CGCTGTGCCT CGCGGCAGGA GGGTTGAGTG GAGTTCTCGC GGAGGCCGAT GATGCAACCA TCACAGCTTC AAGCAGCAGC ATGTTCACCC TGCAGAATGT GCTGTTCGGC CTGCTAGCTG CCACGTTGGG ACTGATTCTG CTGTTGAATC TGAAAGGGAA GAAGCTAAAA TTGCCTCCCG GCCCTCCCGG CATTCCCATT TTCGGCAATT GGCTTCAAAT TGGAGATGAT CTAAATCACC GAAATTTGGC TGAGTTGGCC AAAAAGTATG GAGAAGTGTG CATGCTGAAG ATGGGCCAGA GAAATTACGT CATTGTGTCT AGCCCTGAAG TTGCCAAGGA GGTTCTTCAC ACCCAGGGCG TGGAATTTGG ATCCCGCACC AGAAATGTTG TTTTCGACAT CTTTACAGGA AATGGACAGG ATATGGTGTT CACAGTCTAT GGAGAGCACT GGAGGAGAAT GAGGAGGATC ATGACTGTTC CCTTCTTCAC CAACAAGGTG GTCATGCAGT CTCGATTCGC CTGGGAGGAC GAAATCAATC ATGTTATCAA GGACCTGACC GCTAGTAAGG AGGCCTCTAC CACCGGTGTG ATCATAAGAA GAAGGCTGCA GCTCATGATG TACAATGTTA TGTATCGCAT GATGTTCGAC AGAAGGTTTG AGACAGTGGA CGATCCCCTA TTCGTCAAGC TGAAGGCCGT GAACGGAGAG AGGAGTCGCC TAGCTCAAAG CTTTGAATAC AACTACGGTG ATTTTATCCC CATCTTGAGA CCATTCCTTC GAAAGTATCT TGCCTATTGC CAGCAGCTGA AGGACAAGAG GCTGGCCCTG TTCAAGGAAT ATTTCGTCGA AGAGCGCAAA AAGGTATTGA GCACACGAGG ATCAGGCGGT GGCGAGAAAG CAGCTATTGA TTACATTTTT GAATCCGAGC AAAAGGGAGA GATAAATGAA GATAATGTAT TGTATATCGT CGAGAACATC AATGTTGCTG CTATTGAGAC TACCTTGTGG TCCATCGAGT GGGGAGTGGC TGAGCTGTGC AACAACCCTG ACATTTTCAA GAAATTAAGG AATGAGTTGG ATTCTATCCT CGGTCGTGGA CACTTGGTCT CCGAGCCCGA TCTCCCTCAA CTGCCGTACC TCGGCTCTGT GGTGAAAGAA GTCATGCGAC TACACATGGC CATTCCCCTT CTTGTGCCCC ACATGAATCT ACATCAAGCT AAGCTTGCAG GTTATGATAT ACCAGCAGAG AGCAAAATTC TCGTCAACGC ATGGTGGATA GCAAACAACC CCGAACACTG GGTTGAACCT GAGAAATTCA ACCCTGAGCG CTTCATGGAT GGCAAAATCG AATCCAGCGG GAATGATTTT CGCTTCCTTC CTTTCGGATC TGGGCGCAGA AGCTGTCCGG GTATCATCAT CGCCATTCCG CTGTTGTCCT TGGTCCTAGG TCGGCTTGTC CAGTCATTTG ACTTGTATCC ACCTCCAGGG GTTGATAAGA TTGATATGAC GGAGAAAGGA GGACAATTCA GTCTTTTCAT CAAGACTCAT TACAACATGG TTGTTAAACC GAGGGCTGAT TGAAGCAAGT ATAGAGCTCA CCAAGAATAG AAACTGATGA TGACTAGAAT ATAGAACAAT CAGGAAGCAG AACTTCTCAA CCGACCTGAA GCTGTATAGT TGTGCTGGGG ATCTTAGGTG GTGATCTGTT TCTTGAATGG AGGAGTTATC AGAATAGACA CGACCCTCCA AGTATCTCCT TTTGTGAAAA GTAGGCACAG TAGAGTCTAG ACGAACTAAT TAGAAAAGAA CCTTCAGTAA GGAGGAATAA CGTCTTCCGT TTTCAACTCG ATTTTTTTTG TCGAAGGTCT ATAGCTGTAG CATCCTGCAA AGGGTTCGCT TTCCCCTCCC CCTCCTCAAC ATCTGGTCTG GCTGCCAATT GCTGCTAGGG TTGAGTAGAT TGAAAATAAT CTATACCTGT CCGCCGTTCA CTCTACTGCA AGCGTTGCTT TCGAGGCTTT TTCTAGCGTA CTTATCGTAT TTTCATGATC TTTGCGTGTT GAAAATTTTC TCTGCTCCGT TCCGTTCCGT TCACGATATG TTTTTGTCGA ATTTCGCAAT CCGTAGATCT GAATTGCG |
CDS |
| >Mp6g00020.1 ATGTGGGGTG AGAGAGCAGC CATGGCGCTG TGCCTCGCGG CAGGAGGGTT GAGTGGAGTT CTCGCGGAGG CCGATGATGC AACCATCACA GCTTCAAGCA GCAGCATGTT CACCCTGCAG AATGTGCTGT TCGGCCTGCT AGCTGCCACG TTGGGACTGA TTCTGCTGTT GAATCTGAAA GGGAAGAAGC TAAAATTGCC TCCCGGCCCT CCCGGCATTC CCATTTTCGG CAATTGGCTT CAAATTGGAG ATGATCTAAA TCACCGAAAT TTGGCTGAGT TGGCCAAAAA GTATGGAGAA GTGTGCATGC TGAAGATGGG CCAGAGAAAT TACGTCATTG TGTCTAGCCC TGAAGTTGCC AAGGAGGTTC TTCACACCCA GGGCGTGGAA TTTGGATCCC GCACCAGAAA TGTTGTTTTC GACATCTTTA CAGGAAATGG ACAGGATATG GTGTTCACAG TCTATGGAGA GCACTGGAGG AGAATGAGGA GGATCATGAC TGTTCCCTTC TTCACCAACA AGGTGGTCAT GCAGTCTCGA TTCGCCTGGG AGGACGAAAT CAATCATGTT ATCAAGGACC TGACCGCTAG TAAGGAGGCC TCTACCACCG GTGTGATCAT AAGAAGAAGG CTGCAGCTCA TGATGTACAA TGTTATGTAT CGCATGATGT TCGACAGAAG GTTTGAGACA GTGGACGATC CCCTATTCGT CAAGCTGAAG GCCGTGAACG GAGAGAGGAG TCGCCTAGCT CAAAGCTTTG AATACAACTA CGGTGATTTT ATCCCCATCT TGAGACCATT CCTTCGAAAG TATCTTGCCT ATTGCCAGCA GCTGAAGGAC AAGAGGCTGG CCCTGTTCAA GGAATATTTC GTCGAAGAGC GCAAAAAGGT ATTGAGCACA CGAGGATCAG GCGGTGGCGA GAAAGCAGCT ATTGATTACA TTTTTGAATC CGAGCAAAAG GGAGAGATAA ATGAAGATAA TGTATTGTAT ATCGTCGAGA ACATCAATGT TGCTGCTATT GAGACTACCT TGTGGTCCAT CGAGTGGGGA GTGGCTGAGC TGTGCAACAA CCCTGACATT TTCAAGAAAT TAAGGAATGA GTTGGATTCT ATCCTCGGTC GTGGACACTT GGTCTCCGAG CCCGATCTCC CTCAACTGCC GTACCTCGGC TCTGTGGTGA AAGAAGTCAT GCGACTACAC ATGGCCATTC CCCTTCTTGT GCCCCACATG AATCTACATC AAGCTAAGCT TGCAGGTTAT GATATACCAG CAGAGAGCAA AATTCTCGTC AACGCATGGT GGATAGCAAA CAACCCCGAA CACTGGGTTG AACCTGAGAA ATTCAACCCT GAGCGCTTCA TGGATGGCAA AATCGAATCC AGCGGGAATG ATTTTCGCTT CCTTCCTTTC GGATCTGGGC GCAGAAGCTG TCCGGGTATC ATCATCGCCA TTCCGCTGTT GTCCTTGGTC CTAGGTCGGC TTGTCCAGTC ATTTGACTTG TATCCACCTC CAGGGGTTGA TAAGATTGAT ATGACGGAGA AAGGAGGACA ATTCAGTCTT TTCATCAAGA CTCATTACAA CATGGTTGTT AAACCGAGGG CTGATTGA |
Protein |
| >Mp6g00020.1 MWGERAAMAL CLAAGGLSGV LAEADDATIT ASSSSMFTLQ NVLFGLLAAT LGLILLLNLK GKKLKLPPGP PGIPIFGNWL QIGDDLNHRN LAELAKKYGE VCMLKMGQRN YVIVSSPEVA KEVLHTQGVE FGSRTRNVVF DIFTGNGQDM VFTVYGEHWR RMRRIMTVPF FTNKVVMQSR FAWEDEINHV IKDLTASKEA STTGVIIRRR LQLMMYNVMY RMMFDRRFET VDDPLFVKLK AVNGERSRLA QSFEYNYGDF IPILRPFLRK YLAYCQQLKD KRLALFKEYF VEERKKVLST RGSGGGEKAA IDYIFESEQK GEINEDNVLY IVENINVAAI ETTLWSIEWG VAELCNNPDI FKKLRNELDS ILGRGHLVSE PDLPQLPYLG SVVKEVMRLH MAIPLLVPHM NLHQAKLAGY DIPAESKILV NAWWIANNPE HWVEPEKFNP ERFMDGKIES SGNDFRFLPF GSGRRSCPGI IIAIPLLSLV LGRLVQSFDL YPPPGVDKID MTEKGGQFSL FIKTHYNMVV KPRAD |