Mp5g12010



Description

Annotation

Database ID Description
Gene3D G3DSA:2.130.10.10 -
MobiDBLite mobidb-lite consensus disorder prediction
ProSiteProfiles PS50294 Trp-Asp (WD) repeats circular profile.
PRINTS PR00320 G protein beta WD-40 repeat signature
ProSitePatterns PS00518 Zinc finger RING-type signature.
SMART SM00504 Ubox_2
SMART SM00184 ring_2
Gene3D G3DSA:3.30.40.10 Zinc/RING finger domain, C3HC4 (zinc finger)
ProSiteProfiles PS50089 Zinc finger RING-type profile.
SUPERFAMILY SSF57850 RING/U-box
SUPERFAMILY SSF50978 WD40 repeat-like
ProSiteProfiles PS50082 Trp-Asp (WD) repeats profile.
FunFam G3DSA:2.130.10.10:FF:000090 E3 ubiquitin-protein ligase RFWD2 isoform X1
PANTHER PTHR44080 E3 UBIQUITIN-PROTEIN LIGASE COP1
ProSitePatterns PS00678 Trp-Asp (WD) repeats signature.
CDD cd16504 RING-HC_COP1
SMART SM00320 WD40_4
Coils Coil Coil
Pfam PF00400 WD domain, G-beta repeat
Pfam PF13923 Zinc finger, C3HC4 type (RING finger)
KEGG K10143 E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
KOG KOG0277 Peroxisomal targeting signal type 2 receptor; N-term missing; [U]
KOG KOG0297 TNF receptor-associated factor; C-term missing; [T]
MapolyID Mapoly0143s0030 -
GO GO:0016567 protein ubiquitination
GO GO:0005515 protein binding
GO GO:0061630 ubiquitin protein ligase activity
GO GO:0004842 ubiquitin-protein transferase activity
GO GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process

Nomenclature

Gene symbol Product Transcript ID Status
MpCOP1 A RING finger E3 ubiquitin ligase Published

Associated Literature (AI-based literature mining, Beta-version)

E3 ubiquitin ligase with RING-finger, coiled-coil, and WD40 domains; interacts with full-length MpSPA. It ubiquitinates MpHY5, a reaction promoted by MpSPA; CRISPR knockout lines were lethal, limiting full characterization.

2 core 3 peripheral

Liang Y, Podolec R, Chappuis R, Defossez E, Glauser G, Rötzer J, Stolze SC, Dolan L, Nakagami H, Demarsy E, Ulm R. (2026) · Plant Physiology  research experimental subject
E3 ubiquitin ligase; Mpcop1 mutants show a strong constitutive photomorphogenesis phenotype. COP1 function is much more independent of SPA in Marchantia than in Arabidopsis, and MpHY5 functions antagonistically to MpCOP1.
Zhang, L., et al. (2022b) · International Journal of Molecular Sciences  research experimental subject
E3 ubiquitin ligase with RING-finger, coiled-coil, and WD40 domains; interacts with full-length MpSPA. It ubiquitinates MpHY5, a reaction promoted by MpSPA; CRISPR knockout lines were lethal, limiting full characterization.
Lim, C. J., et al. (2024) · New Phytologist  research citation background
RING-type E3 ligase (Mp5g12010) cited and excluded from the PUB protein classification.
Roetzer J, Asper B, Meir Z, Edelbacher N, Merai Z, Datta S, Dolan L. (2026) · Current biology : CB  research experimental background
CONSTITUTIVELY PHOTOMORPHOGENIC 1; light-responsive gene in the induced set.
Clayton, W. A., et al. (2018) · Plant Journal  research experimental background
UVB-induced COP1 transcript in NanoString panel (annotation).

Transcript models

Transcript ID Location Sequences Extract region
Mp5g12010.1 chr5:15824597..15830825 (-) Gene /  mRNA /  CDS /  Protein
FASTA / GenBank (with flanking bases)
Mp5g12010.2 chr5:15824408..15830841 (-) Gene /  mRNA /  CDS /  Protein
FASTA / GenBank (with flanking bases)

Expression Level powered by MBEX

Link to the original image in MBEX

Single-cell expression scRNA-seq atlas from Wang et al., 2023

Expression of Mp5g12010 across the single-cell RNA-seq atlas. Cluster identities (right) annotate the same UMAP used for the feature plot (left).

Feature plot of Mp5g12010 on UMAP
Feature plot (Seurat scale expression level).
UMAP cluster annotation
Cell-type annotation of the UMAP clusters.
Violin plot by developmental stage
Violin plot by stage. Expression across developmental time points (D0–D31).
Violin plot by cell cluster
Violin plot by cluster. Expression across cell clusters (1–21).

Gene structure:

Sequences:

Gene UTR + CDS + intron

FASTA

mRNA UTR + CDS

FASTA

CDS

FASTA

Protein

FASTA

Gene structure:

Sequences:

Gene UTR + CDS + intron

FASTA

mRNA UTR + CDS

FASTA

CDS

FASTA

Protein

FASTA


MarpolBase / Genome Informatics Lab. NIG.