Mp6g17330
Description
Annotation
| Database | ID | Description |
|---|---|---|
| CDD | cd03506 | Delta6-FADS-like |
| Gene3D | G3DSA:3.10.120.10 | - |
| KOG | KOG4232 | Delta 6-fatty acid desaturase/delta-8 sphingolipid desaturase; [I] |
| MobiDBLite | mobidb-lite | consensus disorder prediction |
| PANTHER | PTHR19353 | FATTY ACID DESATURASE 2 |
| PIRSF | PIRSF015921 | FA_sphingolip_des |
| Pfam | PF00173 | Cytochrome b5-like Heme/Steroid binding domain |
| Pfam | PF00487 | Fatty acid desaturase |
| ProSiteProfiles | PS50255 | Cytochrome b5 family, heme-binding domain profile. |
| SMART | SM01117 | Cyt_b5_2 |
| SUPERFAMILY | SSF55856 | Cytochrome b5-like heme/steroid binding domain |
| GO | GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| GO | GO:0006629 | lipid metabolic process |
| GO | GO:0016020 | membrane |
| GO | GO:0016491 | oxidoreductase activity |
| MapolyID | Mapoly0184s0017 | - |
Nomenclature
| Gene symbol | Product | Transcript ID | Status |
|---|---|---|---|
| MpDES6 | Delta6 fatty acid desaturase | Published | |
| MpFAD12 | Secondary metabolism enzyme | Provisional |
This is a provisional entry. If you want to update the entry, please contact the administrator.
Associated Literature (AI-based literature mining)
Delta6 fatty acid desaturase; MpDES6 mediates two Delta6-desaturation reactions, linoleic acid (LA; 18:2Delta9,12) to gamma-linolenic acid (GLA;18:3Delta6,9,12) in the n-6 pathway, and alpha-linolenic acid (ALA; 18:3Delta9,12,15) to stearidonic acid (STA; 18:4Delta6,9,12,15) in the n-3 pathway. (from nomenclature)
3 core 2 peripheral
Kneeshaw, S., et al. (2022)
· PNAS research experimental subject
Δ6-desaturase in the EPA biosynthetic route. CRISPR Mpdes6 mutants (including double mutants) were analyzed for C20-OPDA and Δ4-dn-OPDA accumulation after wounding.
Kihara H, Tanaka M, Yamato KT, Horibata A, Yamada A, Kita S, Ishizaki K, Kajikawa M, Fukuzawa H, Kohchi T, Akakabe Y, Matsui K. (2014)
· Phytochemistry research experimental subject
A des6 knockout line lacking arachidonic/eicosapentaenoic acid produced almost no C8 volatiles, showing that MpDES6-derived arachidonic acid is the essential precursor of 1-octen-3-ol and related C8 volatiles released on wounding.
Kajikawa M, Yamato KT, Kohzu Y, Nojiri M, Sakuradani E, Shimizu S, Sakai Y, Fukuzawa H, Ohyama K. (2004)
· Plant Mol Biol research experimental subject
Delta-6-desaturase cDNA isolated and functionally characterized; its co-expression with MpELO1 and MpDES5 in Pichia pastoris produced arachidonic and eicosapentaenoic acids. Delta-6 desaturation appeared to occur in both glycerolipids and the acyl-CoA pool.
Liang, W., et al. (2024)
· Plant Physiology research citation background
Cited as the Delta-6-desaturase required for hexadecatrienoic acid (16:3) biosynthesis in the hexadecanoid pathway; no experimental work here.
Galassi L, Medina-Paz F, Jimenez-Aleman GH. (2026)
· Plants (Basel) review citation background
Bryophyte-specific ER Delta6-desaturase; Mpdes6 is depleted in EPA and lacks C20-OPDA and Delta4-dn-iso-OPDA.
Single-cell expression scRNA-seq atlas from Wang et al., 2023
Expression of Mp6g17330 across the single-cell RNA-seq atlas. Cluster identities (right) annotate the same UMAP used for the feature plot (left).
Gene structure:
Sequences: |
Gene UTR + CDS + intron |
| >Mp6g17330.1 GGTGGGACTG GGGCCCCTAC AAAGATCTTG GAAAAGATCT TGAGGCAGCG AGCGTCTCAT CGATCGGCTG CTGTCGTTGC AGCGTTAGTA TTTGAGCAGA GCTCGCGCCT GCTCCTGTTC TATAGATCCA ATTTCATAAG TCGACGAGAA AGGCAGAAGG CGAGAAGCGG CAGGCAGCGA GCGCGAGCGC CAGAGCTCTT GCTCCCCTCG CTCATCGCTC GCATTGCCGC ATTTTGTGAG TGTCGGACTG ATCACTCAGT CCGTCACTGC AAACGCGAGC GAGCGAGAGT GCGAGTGAGC GAGCGAGCGA GCGAGAGCCG CGGTGTGTCT GTGAGATCCA ATCCTTTTTC TGCTTTGCGC GCTGTGGGGC GCGATGGCCT CGTCCACCAC CACCGCCGTG AAGCAATCTT CGGGTGGGCT GTGGTCGAAA TGGGGCACCG GCAGCAACTT GAGCTTCGTG TCGCGCAAGG AGCAGCAGCA GCAGCAGCAG CAGAGCTCTC CCGAGGCGTC GACTCCCGCG GCGCAGCAGG AGAAATCCAT CAGTAGAGAA TCCATCCCCG AGGGCTTCTT GACCGTGGAG GAGGTGTCGA AGCACGACAA TCCGAGCGAC TGCTGGATCG TCATCAACGA CAAGGTGTAC GACGTGAGCG CATTCGGGAA GACGCATCCG GGCGGCCCTG TGATCTTCAC GCAGGCCGGC CGCGACGCCA CGGATTCTTT CAAGGTTTTC CACTCCGCCA AGGCGTGGCA GTTTCTCCAG GACCTGTACA TCGGAGATCT GTACAATGCC GAGCCAGTGT CGGAGCTGGT GAAGGATTAC CGAGACCTGA GGACGGCGTT CATGCGTTCT CAGCTATTCA AGAGCAGTAA AATGTACTAC GTGACCAAGT GCGTCACAAA TTTTGCAATT CTTGCCGCCA GTCTCGCAGT CATCGCGTGG AGCCAGACGT ATCTGGCGGT TTTGTGCTCC AGTTTCCTGT TGGCTCTCTT CTGGCAGCAA TGTGGATGGT TATCGCACGA TTTTCTCCAC CACCAGGTGA CCGAGAACCG ATCGCTCAAC ACGTACTTCG GCGGCCTGTT CTGGGGTAAC TTCGCCCAGG GCTACAGCGT GGGATGGTGG AAGACCAAGC ACAATGTGCA CCACGCGGCC ACGAACGAAT GCGACGACAA GTATCAGCCC ATCGATCCCG ACATCGACAC CGTGCCCCTG CTCGCCTGGA GCAAGGAAAT CTTGGCCACC GTCGACGACC AATTCTTCCG ATCGATCATC AGCGTGCAGC ACCTTCTGTT CTTCCCGCTC CTCTTCTTGG CAAGATTCAG CTGGCTGCAT TCGAGTTGGG CCCACGCCAG CAACTTCGAG ATGCCTCGGT ACATGAGATG GGCGGAGAAG GCCTCGCTCC TCGGGCACTA CGGCGCCTCA ATCGGCGCCG CCTTCTACAT TTTGCCCATC CCCCAGGCCA TCTGCTGGCT CTTCTTGTCG CAACTGTTTT GCGGCGCTCT GCTCAGCATT GTCTTCGTGA TCAGCCACAA TGGCATGGAT GTGTACAACG ACCCCCGGGA CTTCGTGACG GCCCAAGTCA CCTCGACCAG AAACATCGAA GGCAACTTCT TCAACGACTG GTTCACCGGA GGCCTGAACA GGCAGATTGA GCACCATCTG TTTCCGTCTC TTCCGAGGCA CAACCTCGCC AAGGTCGCGC CACACGTCAA GGCGCTCTGC GCCAAGCACG GTTTGCATTA CGAAGAATTG AGTCTGGGCA CGGGAGTCTG TCGTGTCTTC AATCGGCTAG TAGAGGTAGC ATACGCTGCG AAAGTATAGA TCGACGAGAG TTTCCCACCA ACACAGGTGA GCCTCGACAT TCTTTGTACA CATTCTTCAT GTCTTTTGAA TCTTGCTTCA CCAGATTCGG CGGCCGTAGA TTTGGGATTG GAGGTCCCTG TGATTACCAT AACCTTTGCT AGTACGGTAA ATAATGAGCT CGAGGCTATT TTAGGTCAAA GATTTCAAGG GACATCACGT CTATTTTGTA CTAAATTAAG GATTGATCCC TCTCAACCAC TGCGCGAGTT CGTTCGATTG GTTCAGATAT GCCCTGTTAG GAAAGTGGTC ACATCGTGAA GTCTGTCGTG TGTATATTCT TTTTCCGCTG GACCTCTGCC ATCGCTCACA ATTCCTCCTC CTCGTGTAAC CTAGTAACTT ACGCGTCGTG CTACTGTCAG ATGTTCTTAC TTTATCCTCC TGAGCGGTGG TCACTGAAGA GAAAGAACTC TACGTGACTC CGAGATCAGT GTGTTTCCTC AGAGAGATGG AAGTAAATGG TGGCCTTTGC AATGATTCTG TTGTGCAGTT AGAACAAGGG AATAGTACGA GAGAAGGAGA CAGCAACCTG GACTTTTTGT TCCTGATGTT GCATACTTTC TCGAATATAC GTCTCCACGC CTTCAAGTTT CAGCTTCAAC TGATTGTCTT CAGTAACCAT CGCTTGCTCC AACTGGGCGA CCTGCAGAAT TGAAGATCAG TTTTACTGAG TTTGTACCGA GAGTTTCCCA AATTTTGTTG TAGGCTGATG ACCCAATCCT AGCATACACT TTAGGAATAA GCAGTCTCAA CATAATTAGG TCCATCATTC AGCAATTTCG ATACAGCGCC TGGGATTCGA CGAGTTTACA CGATGAGTAT GGCTTGTAAC TGGCCTTCTC AAGGTAGCCT TGGATCTCCC CGGGCCTCTT GCCATCCCAT TCACCCAATC GAGATTCTGC AGTCTCCAAC CTTTTCTGGA AGTTCTCAAT CTGTAACCTC TGTTGTAGAG ATAGCATACG CCACAAGACA AGGTCTTTGT GAACACAGTC GTCTAACAAA CAGCAAGTTG TGTGGATTGG CATCTAAATA ACCGCCTCTG GTCAAGTAAC AGCAGGTGTT CCGCAGTTTC CAGGAACATA CTTTGTTTCT GTCACAGCCA GGCGGTGAAT AGTAAAGCCA ATTCAACACA TACGGGAGAA GATGGGTCGA TATTTGTATT TGGCAGGGTG TCCAGATTTC ACCCATCAGT CTCTCACTTG CTTGTATGTC CCTGACGTGC TTCAAAATTT TGCGCGGGGA ATCATCAATA TACTTACCAT TTGTAAAGTC TGCTTCCGGT GTTCTGTTTC CACTACTTGA AGTTTCTTGT TTACTTGCTG GGCTTGATAG TCGGCATTAT CTGCC |
mRNA UTR + CDS |
| >Mp6g17330.1 GGTGGGACTG GGGCCCCTAC AAAGATCTTG GAAAAGATCT TGAGGCAGCG AGCGTCTCAT CGATCGGCTG CTGTCGTTGC AGCGTTAGTA TTTGAGCAGA GCTCGCGCCT GCTCCTGTTC TATAGATCCA ATTTCATAAG TCGACGAGAA AGGCAGAAGG CGAGAAGCGG CAGGCAGCGA GCGCGAGCGC CAGAGCTCTT GCTCCCCTCG CTCATCGCTC GCATTGCCGC ATTTTGTGAG TGTCGGACTG ATCACTCAGT CCGTCACTGC AAACGCGAGC GAGCGAGAGT GCGAGTGAGC GAGCGAGCGA GCGAGAGCCG CGGTGTGTCT GTGAGATCCA ATCCTTTTTC TGCTTTGCGC GCTGTGGGGC GCGATGGCCT CGTCCACCAC CACCGCCGTG AAGCAATCTT CGGGTGGGCT GTGGTCGAAA TGGGGCACCG GCAGCAACTT GAGCTTCGTG TCGCGCAAGG AGCAGCAGCA GCAGCAGCAG CAGAGCTCTC CCGAGGCGTC GACTCCCGCG GCGCAGCAGG AGAAATCCAT CAGTAGAGAA TCCATCCCCG AGGGCTTCTT GACCGTGGAG GAGGTGTCGA AGCACGACAA TCCGAGCGAC TGCTGGATCG TCATCAACGA CAAGGTGTAC GACGTGAGCG CATTCGGGAA GACGCATCCG GGCGGCCCTG TGATCTTCAC GCAGGCCGGC CGCGACGCCA CGGATTCTTT CAAGGTTTTC CACTCCGCCA AGGCGTGGCA GTTTCTCCAG GACCTGTACA TCGGAGATCT GTACAATGCC GAGCCAGTGT CGGAGCTGGT GAAGGATTAC CGAGACCTGA GGACGGCGTT CATGCGTTCT CAGCTATTCA AGAGCAGTAA AATGTACTAC GTGACCAAGT GCGTCACAAA TTTTGCAATT CTTGCCGCCA GTCTCGCAGT CATCGCGTGG AGCCAGACGT ATCTGGCGGT TTTGTGCTCC AGTTTCCTGT TGGCTCTCTT CTGGCAGCAA TGTGGATGGT TATCGCACGA TTTTCTCCAC CACCAGGTGA CCGAGAACCG ATCGCTCAAC ACGTACTTCG GCGGCCTGTT CTGGGGTAAC TTCGCCCAGG GCTACAGCGT GGGATGGTGG AAGACCAAGC ACAATGTGCA CCACGCGGCC ACGAACGAAT GCGACGACAA GTATCAGCCC ATCGATCCCG ACATCGACAC CGTGCCCCTG CTCGCCTGGA GCAAGGAAAT CTTGGCCACC GTCGACGACC AATTCTTCCG ATCGATCATC AGCGTGCAGC ACCTTCTGTT CTTCCCGCTC CTCTTCTTGG CAAGATTCAG CTGGCTGCAT TCGAGTTGGG CCCACGCCAG CAACTTCGAG ATGCCTCGGT ACATGAGATG GGCGGAGAAG GCCTCGCTCC TCGGGCACTA CGGCGCCTCA ATCGGCGCCG CCTTCTACAT TTTGCCCATC CCCCAGGCCA TCTGCTGGCT CTTCTTGTCG CAACTGTTTT GCGGCGCTCT GCTCAGCATT GTCTTCGTGA TCAGCCACAA TGGCATGGAT GTGTACAACG ACCCCCGGGA CTTCGTGACG GCCCAAGTCA CCTCGACCAG AAACATCGAA GGCAACTTCT TCAACGACTG GTTCACCGGA GGCCTGAACA GGCAGATTGA GCACCATCTG TTTCCGTCTC TTCCGAGGCA CAACCTCGCC AAGGTCGCGC CACACGTCAA GGCGCTCTGC GCCAAGCACG GTTTGCATTA CGAAGAATTG AGTCTGGGCA CGGGAGTCTG TCGTGTCTTC AATCGGCTAG TAGAGGTAGC ATACGCTGCG AAAGTATAGA TCGACGAGAG TTTCCCACCA ACACAGTTAG AACAAGGGAA TAGTACGAGA GAAGGAGACA GCAACCTGGA CTTTTTGTTC CTGATGTTGC ATACTTTCTC GAATATACGT CTCCACGCCT TCAAGTTTCA GCTTCAACTG ATTGTCTTCA GTAACCATCG CTTGCTCCAA CTGGGCGACC TGCAGAATTG AAGATCAGTT TTACTGAGTT TGTACCGAGA GTTTCCCAAA TTTTGTTGTA GGCTGATGAC CCAATCCTAG CATACACTTT AGGAATAAGC AGTCTCAACA TAATTAGGTC CATCATTCAG CAATTTCGAT ACAGCGCCTG GGATTCGACG AGTTTACACG ATGAGTATGG CTTGTAACTG GCCTTCTCAA GGTAGCCTTG GATCTCCCCG GGCCTCTTGC CATCCCATTC ACCCAATCGA GATTCTGCAG TCTCCAACCT TTTCTGGAAG TTCTCAATCT GTAACCTCTG TTGTAGAGAT AGCATACGCC ACAAGACAAG GTCTTTGTGA ACACAGTCGT CTAACAAACA GCAAGTTGTG TGGATTGGCA TCTAAATAAC CGCCTCTGGT CAAGTAACAG CAGGTGTTCC GCAGTTTCCA GGAACATACT TTGTTTCTGT CACAGCCAGG CGGTGAATAG TAAAGCCAAT TCAACACATA CGGGAGAAGA TGGGTCGATA TTTGTATTTG GCAGGGTGTC CAGATTTCAC CCATCAGTCT CTCACTTGCT TGTATGTCCC TGACGTGCTT CAAAATTTTG CGCGGGGAAT CATCAATATA CTTACCATTT GTAAAGTCTG CTTCCGGTGT TCTGTTTCCA CTACTTGAAG TTTCTTGTTT ACTTGCTGGG CTTGATAGTC GGCATTATCT GCC |
CDS |
| >Mp6g17330.1 ATGGCCTCGT CCACCACCAC CGCCGTGAAG CAATCTTCGG GTGGGCTGTG GTCGAAATGG GGCACCGGCA GCAACTTGAG CTTCGTGTCG CGCAAGGAGC AGCAGCAGCA GCAGCAGCAG AGCTCTCCCG AGGCGTCGAC TCCCGCGGCG CAGCAGGAGA AATCCATCAG TAGAGAATCC ATCCCCGAGG GCTTCTTGAC CGTGGAGGAG GTGTCGAAGC ACGACAATCC GAGCGACTGC TGGATCGTCA TCAACGACAA GGTGTACGAC GTGAGCGCAT TCGGGAAGAC GCATCCGGGC GGCCCTGTGA TCTTCACGCA GGCCGGCCGC GACGCCACGG ATTCTTTCAA GGTTTTCCAC TCCGCCAAGG CGTGGCAGTT TCTCCAGGAC CTGTACATCG GAGATCTGTA CAATGCCGAG CCAGTGTCGG AGCTGGTGAA GGATTACCGA GACCTGAGGA CGGCGTTCAT GCGTTCTCAG CTATTCAAGA GCAGTAAAAT GTACTACGTG ACCAAGTGCG TCACAAATTT TGCAATTCTT GCCGCCAGTC TCGCAGTCAT CGCGTGGAGC CAGACGTATC TGGCGGTTTT GTGCTCCAGT TTCCTGTTGG CTCTCTTCTG GCAGCAATGT GGATGGTTAT CGCACGATTT TCTCCACCAC CAGGTGACCG AGAACCGATC GCTCAACACG TACTTCGGCG GCCTGTTCTG GGGTAACTTC GCCCAGGGCT ACAGCGTGGG ATGGTGGAAG ACCAAGCACA ATGTGCACCA CGCGGCCACG AACGAATGCG ACGACAAGTA TCAGCCCATC GATCCCGACA TCGACACCGT GCCCCTGCTC GCCTGGAGCA AGGAAATCTT GGCCACCGTC GACGACCAAT TCTTCCGATC GATCATCAGC GTGCAGCACC TTCTGTTCTT CCCGCTCCTC TTCTTGGCAA GATTCAGCTG GCTGCATTCG AGTTGGGCCC ACGCCAGCAA CTTCGAGATG CCTCGGTACA TGAGATGGGC GGAGAAGGCC TCGCTCCTCG GGCACTACGG CGCCTCAATC GGCGCCGCCT TCTACATTTT GCCCATCCCC CAGGCCATCT GCTGGCTCTT CTTGTCGCAA CTGTTTTGCG GCGCTCTGCT CAGCATTGTC TTCGTGATCA GCCACAATGG CATGGATGTG TACAACGACC CCCGGGACTT CGTGACGGCC CAAGTCACCT CGACCAGAAA CATCGAAGGC AACTTCTTCA ACGACTGGTT CACCGGAGGC CTGAACAGGC AGATTGAGCA CCATCTGTTT CCGTCTCTTC CGAGGCACAA CCTCGCCAAG GTCGCGCCAC ACGTCAAGGC GCTCTGCGCC AAGCACGGTT TGCATTACGA AGAATTGAGT CTGGGCACGG GAGTCTGTCG TGTCTTCAAT CGGCTAGTAG AGGTAGCATA CGCTGCGAAA GTATAG |
Protein |
| >Mp6g17330.1 MASSTTTAVK QSSGGLWSKW GTGSNLSFVS RKEQQQQQQQ SSPEASTPAA QQEKSISRES IPEGFLTVEE VSKHDNPSDC WIVINDKVYD VSAFGKTHPG GPVIFTQAGR DATDSFKVFH SAKAWQFLQD LYIGDLYNAE PVSELVKDYR DLRTAFMRSQ LFKSSKMYYV TKCVTNFAIL AASLAVIAWS QTYLAVLCSS FLLALFWQQC GWLSHDFLHH QVTENRSLNT YFGGLFWGNF AQGYSVGWWK TKHNVHHAAT NECDDKYQPI DPDIDTVPLL AWSKEILATV DDQFFRSIIS VQHLLFFPLL FLARFSWLHS SWAHASNFEM PRYMRWAEKA SLLGHYGASI GAAFYILPIP QAICWLFLSQ LFCGALLSIV FVISHNGMDV YNDPRDFVTA QVTSTRNIEG NFFNDWFTGG LNRQIEHHLF PSLPRHNLAK VAPHVKALCA KHGLHYEELS LGTGVCRVFN RLVEVAYAAK V |