Mp2g12950



Description

Annotation

Database ID Description
CDD cd00892 PIKKc_ATR
FunFam G3DSA:1.10.1070.11:FF:000024 Serine/threonine-protein kinase ATR
Gene3D G3DSA:1.10.1070.11 -
Gene3D G3DSA:1.25.10.10 -
Gene3D G3DSA:1.25.40.10 Tetratricopeptide repeat domain
Gene3D G3DSA:3.30.1010.10 -
KEGG K06640 serine/threonine-protein kinase ATR [EC:2.7.11.1]
KOG KOG0890 Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination; N-term missing; [TBLD]
MobiDBLite mobidb-lite consensus disorder prediction
PANTHER PTHR11139 ATAXIA TELANGIECTASIA MUTATED ATM -RELATED
Pfam PF00454 Phosphatidylinositol 3- and 4-kinase
Pfam PF02259 FAT domain
Pfam PF02260 FATC domain
Pfam PF08064 UME (NUC010) domain
ProSitePatterns PS00916 Phosphatidylinositol 3- and 4-kinases signature 2.
ProSiteProfiles PS50290 Phosphatidylinositol 3- and 4-kinases catalytic domain profile.
ProSiteProfiles PS51189 FAT domain profile.
ProSiteProfiles PS51190 FATC domain profile.
SMART SM00146 pi3k_hr1_6
SMART SM00802 UME_cls
SMART SM01343 FATC_2
SUPERFAMILY SSF48371 ARM repeat
SUPERFAMILY SSF48452 TPR-like
SUPERFAMILY SSF56112 Protein kinase-like (PK-like)
GO GO:0000077 DNA damage checkpoint signaling
GO GO:0005634 nucleus
GO GO:0005515 protein binding
GO GO:0004674 protein serine/threonine kinase activity
GO GO:0006468 protein phosphorylation
GO GO:0000723 telomere maintenance
GO GO:0016301 kinase activity
MapolyID Mapoly0026s0077 -

Nomenclature

Gene symbol Product Transcript ID Status
MpATR ATM- and RAD3-related (ATR) DNA-damage checkpoint kinase Published
Locus assigned by MarpolBase literature-mining curation (2026-10): Stated in the paper: "a single MpATR gene (Mp2g12950)"; the locus is annotated KEGG K06640 (ATR).

Associated Literature (AI-based literature mining)

MpATR is the M. polymorpha homolog of the ATR kinase, identified and functionally characterized here. It preserves meristematic cells during replication stress and, unlike vascular-plant ATR, is essential for repressing proliferation of differentiated cells; Mpatr mutants show progressively severe growth defects across clonal generations.

1 core 0 peripheral

Li QQ, Li H, De Moor J, Sbrocca I, Xiang Y, Yang SL, Jiang ZY, He L, Wang JY, Herbst J, van de Cotte B, De Smet I, Cimini S, De Veylder L. (2026) · The Plant cell  research experimental subject
MpATR is the M. polymorpha homolog of the ATR kinase, identified and functionally characterized here. It preserves meristematic cells during replication stress and, unlike vascular-plant ATR, is essential for repressing proliferation of differentiated cells; Mpatr mutants show progressively severe growth defects across clonal generations.

Transcript models

Transcript ID Location Sequences Extract region
Mp2g12950.1 chr2:13905829..13920211 (-) Gene /  mRNA /  CDS /  Protein
FASTA / GenBank (with flanking bases)

Expression Level powered by MBEX

Link to the original image in MBEX

Single-cell expression scRNA-seq atlas from Wang et al., 2023

Expression of Mp2g12950 across the single-cell RNA-seq atlas. Cluster identities (right) annotate the same UMAP used for the feature plot (left).

Feature plot of Mp2g12950 on UMAP
Feature plot (Seurat scale expression level).
UMAP cluster annotation
Cell-type annotation of the UMAP clusters.
Violin plot by developmental stage
Violin plot by stage. Expression across developmental time points (D0–D31).
Violin plot by cell cluster
Violin plot by cluster. Expression across cell clusters (1–21).

Gene structure:

Sequences:

Gene UTR + CDS + intron

FASTA

mRNA UTR + CDS

FASTA

CDS

FASTA

Protein

FASTA

MarpolBase / Genome Informatics Lab. NIG.