Mp6g17330



Description

Annotation

Database ID Description
PIRSF PIRSF015921 FA_sphingolip_des
PANTHER PTHR19353 FATTY ACID DESATURASE 2
ProSiteProfiles PS50255 Cytochrome b5 family, heme-binding domain profile.
MobiDBLite mobidb-lite consensus disorder prediction
Pfam PF00487 Fatty acid desaturase
SUPERFAMILY SSF55856 Cytochrome b5-like heme/steroid binding domain
Pfam PF00173 Cytochrome b5-like Heme/Steroid binding domain
Gene3D G3DSA:3.10.120.10 -
CDD cd03506 Delta6-FADS-like
SMART SM01117 Cyt_b5_2
KOG KOG4232 Delta 6-fatty acid desaturase/delta-8 sphingolipid desaturase; [I]
MapolyID Mapoly0184s0017 -
GO GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO GO:0006629 lipid metabolic process
GO GO:0016020 membrane
GO GO:0016491 oxidoreductase activity

Nomenclature

Gene symbol Product Transcript ID Status
MpDES6 Δ6 fatty acid desaturase Published
MpFAD12 Secondary metabolism enzyme Provisional
This is a provisional entry. If you want to update the entry, please contact the administrator.

Associated Literature (AI-based literature mining, Beta-version)

Δ6 fatty acid desaturase; MpDES6 mediates two Δ6-desaturation reactions, linoleic acid (LA; 18:2Δ9,12) to γ-linolenic acid (GLA;18:3Δ6,9,12) in the n-6 pathway, and α-linolenic acid (ALA; 18:3Δ9,12,15) to stearidonic acid (STA; 18:4Δ6,9,12,15) in the n-3 pathway. (from nomenclature)

3 core 1 peripheral

Kneeshaw, S., et al. (2022) · PNAS  research experimental subject
Δ6-desaturase in the EPA biosynthetic route. CRISPR Mpdes6 mutants (including double mutants) were analyzed for C20-OPDA and Δ4-dn-OPDA accumulation after wounding.
Kihara H, Tanaka M, Yamato KT, Horibata A, Yamada A, Kita S, Ishizaki K, Kajikawa M, Fukuzawa H, Kohchi T, Akakabe Y, Matsui K. (2014) · Phytochemistry  research experimental subject
A des6 knockout line lacking arachidonic/eicosapentaenoic acid produced almost no C8 volatiles, showing that MpDES6-derived arachidonic acid is the essential precursor of 1-octen-3-ol and related C8 volatiles released on wounding.
Kajikawa M, Yamato KT, Kohzu Y, Nojiri M, Sakuradani E, Shimizu S, Sakai Y, Fukuzawa H, Ohyama K. (2004) · Plant Mol Biol  research experimental subject
Delta-6-desaturase cDNA isolated and functionally characterized; its co-expression with MpELO1 and MpDES5 in Pichia pastoris produced arachidonic and eicosapentaenoic acids. Delta-6 desaturation appeared to occur in both glycerolipids and the acyl-CoA pool.
Liang, W., et al. (2024) · Plant Physiology  research citation background
Cited as the Delta-6-desaturase required for hexadecatrienoic acid (16:3) biosynthesis in the hexadecanoid pathway; no experimental work here.

Transcript models

Transcript ID Location Sequences Extract region
Mp6g17330.1 chr6:22153482..22156686 (-) Gene /  mRNA /  CDS /  Protein
FASTA / GenBank (with flanking bases)

Expression Level powered by MBEX

Link to the original image in MBEX

Single-cell expression scRNA-seq atlas from Wang et al., 2023

Expression of Mp6g17330 across the single-cell RNA-seq atlas. Cluster identities (right) annotate the same UMAP used for the feature plot (left).

Feature plot of Mp6g17330 on UMAP
Feature plot (Seurat scale expression level).
UMAP cluster annotation
Cell-type annotation of the UMAP clusters.
Violin plot by developmental stage
Violin plot by stage. Expression across developmental time points (D0–D31).
Violin plot by cell cluster
Violin plot by cluster. Expression across cell clusters (1–21).

Gene structure:

Sequences:

Gene UTR + CDS + intron

FASTA

mRNA UTR + CDS

FASTA

CDS

FASTA

Protein

FASTA

MarpolBase / Genome Informatics Lab. NIG.