MarpolBase - Microtubule associated protein WAVE DAMPENED2-LIKE (WDL) controls microtubule bundling and the stability of the site of tipgrowth in Marchantia polymorpha rhizoids.

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Microtubule associated protein WAVE DAMPENED2-LIKE (WDL) controls microtubule bundling and the stability of the site of tipgrowth in Marchantia polymorpha rhizoids.

Champion, C., et al. · 2021 · PLoS Genetics research

doi:10.1371/journal.pgen.1009533 PMID:34086675 PMC8177534

Linked genes (11) 3 core 8 peripheral

Gene ID	Name	Evidence / Role	Function (this paper)
—	Mapoly2834s1300 missing	experimental subject	Locus encoding MpNEK (NIMA-RELATED PROTEIN KINASE), the causative gene for the wavy-rhizoid phenotype identified by genome sequencing of UV mutants.
Mp5g04500	MpNEK	experimental subject	NIMA-RELATED kinase that destabilizes microtubules at growing tips; loss-of-function mutants produce wavy rhizoids.
Mp7g06100	MpWDL	experimental subject	WAVE DAMPENED2-LIKE microtubule-binding protein, central subject of the paper, promoting microtubule bundling and longitudinal organization along the rhizoid shank.
Mp3g23400	MpEF1	experimental tool	Reference gene used to normalize transcript levels in qPCR expression analyses of MpWDL and related targets.
—	MpRabA4 missing	experimental tool	Rab GTPase used as a YFP-tagged endomembrane/secretory-vesicle marker to track trafficking toward the apical dome during tip growth.
Mp2g16780	MpTUB1	experimental tool	Tubulin used as a GFP fusion reporter to visualize and quantify microtubule organization in wild-type versus wdl mutant rhizoids.
—	Mapoly1040s1130 missing	sequence background	Candidate missense SNP locus from filtering, homologous to an Arabidopsis iron-sulfur cluster gene; did not co-segregate with the phenotype.
—	Mapoly2145s1300 missing	sequence background	One of six candidate SNP loci found during mutant genome filtering; a missense variant homologous to an Arabidopsis gene, judged non-causative.
—	Mapoly2528s1180 missing	sequence background	Candidate missense SNP locus identified in the SNP discovery pipeline, homologous to an Arabidopsis gene; not validated as causative.
—	Mapoly4343s1080 missing	sequence background	Candidate missense SNP locus from the mutant filtering pipeline, homologous to an Arabidopsis bZIP-type gene; excluded as causative.
—	Mapoly4751s1220 missing	sequence background	Candidate missense SNP locus with no clear Arabidopsis homolog; listed among filtered variants and excluded from further study.