Dong, S., et al. · 2025 · Nature Genetics research
doi:10.1038/s41588-025-02325-9 PMID:40983756 PMC12513842
| Gene ID | Name | Evidence / Role | Function (this paper) |
|---|---|---|---|
| Mp4g17190 | Mp4g17190 missing | sequence subject | Orphan gene proposed to have originated from noncoding regions with high cross-subspecies similarity, where stop codons were converted to sense codons by single-base mutations. Case study of de novo gene origination. |
| Mp7g02380 | Mp7g02380 missing | sequence subject | Orphan/de novo gene in M. polymorpha ssp. ruderalis shown to have increasing sequence similarity to orthologous noncoding regions, illustrating proto-gene to gene evolution via stop-codon loss. Used as a case study of de novo gene birth. |
| Mp8g04260 | Mp8g04260 missing | experimental subject | HNL-type resistance gene from M. polymorpha overexpressed in tobacco leaves, where it triggered hypersensitive-response cell death. Demonstrates its immune-related function, validating the predicted resistance gene family. |
| Mp5g08960 | MpNBS-LRR15 | experimental subject | NHAT-type resistance gene from M. polymorpha that was overexpressed in Nicotiana benthamiana leaves, where it induced a hypersensitive-response cell death. Confirms an immune/cell-death function for this gene, used as functional validation of bryophyte resistance-gene predictions. |